Use of native type II collagen as part of the multiagent Gibelli Flex Active


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Abstract

The paper reviews studies of the active ingredients of biologically active additive (BAA) in the dietary supplement Gibelli Flex Active. The BAA components have anti-inflammatory, chondroprotective, antioxidant, and immunomodulatory effects in the treatment of patients with osteoarthritis and improve their mobility and quality of life. Gibelli Flex Active has a good safety profile and can be recommended to treat locomotor diseases in patients of any age.

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About the authors

T. Potupchik

Krasnoyarsk State Medical University

Email: potupchik_tatyana@mail.ru
Candidate of Medical Sciences

L. Evert

Research Institute of Medical Problems of the North, Branch Office, Federal Research Center «Krasnoyarsk Research Center, Siberian Branch, Russian Academy of Sciences»

MD

Yu. Akhmeldinova

Krasnoyarsk State Medical University

References

  1. Алексеева Л.И. Остеоартроз - проблема века // Мед. совет. - 2013; 5: 2-3.
  2. Бадокин В.В. Существуют ли хондропротективные препараты? // РМЖ. -2010; 30: 1848.
  3. Дыдыкина И.С., Дыдыкина П.С., Алексеева О.Г. Вклад микроэлементов (меди, марганца, цинка, бора) в здоровье кости: вопросы профилактики и лечения остеопении и остеопороза // Эффективная фармакотерапия. - 2013; 38: 42-9.
  4. Каратеев А.Е., Насонова В.А. Возможности повышения эффективности и безопасности терапии пациентов с поясничной болью // Фарматека. - 2013; 13: 75-7.
  5. Кцоева Е.Л., Гатагонова Т.М., Кцоева С.А. Комбинированное лечение больных остеоартрозом коленного сустава с использованием витамина С // Кубанский научн. мед. вестн. - 2013; 5 (140): 121-4.
  6. Насонов Е.Л. Нестероидные противовоспалительные препараты / М., 2010.
  7. Светлова М.С. Патогенетическое лечение остеоартроза коленных суставов // Современная ревматология. - 2012; 3: 1-5.
  8. Спиричев В.Б. Витамины, витаминоподобные и минеральные вещества. Справочник / М.: Миклом, 2004.
  9. Третьяк Л.Н., Герасимов Е.М. Специфика влияния селена на организм человека и животных (применительно к проблеме создания селеносодержащих продуктов питания) // Вестник Оренбургского гос. университета. - 2007; 12 (79): 136-45.
  10. Хабаров А.А., Будко Е.В., Лушов К.А. и др. Цинк: актуальность и характеристики биодобавок (обзор литературы) // Современные проблемы науки и образования. - 2012; 3: [Электронный ресурс]. Режим доступа http://science-education.ru/ru/article/view?id=6416
  11. Ausar S., Beltramo D., Castagna L. et al. Treatment of rheumatoid arthritis by oral administration of bovine tracheal type II collagen // Rheumat. Internat. -2001; 20: 138-44.
  12. Bagchi D., Misner B., Bagchi M. et al. Effects of orally administered undenatured type II collagen against arthritic inflammatory diseases: a mechanistic exploration // Int. J. Clin. Pharmacol. Res. - 2002; 22: 101-10.
  13. Bakilan F., Armagan O., Ozgen M. et al. Effects of Native Collagen Type II Treatment // Eurasian J. Med. - 2016; 48: 95-101.
  14. Crowley D., Lau F., Sharma P. et al. Safety and efficacy of undenatured type II collagen in the treatment of osteoarthritis of the knee: a clinical trial // Int. J. Med. Sci. - 2009; 6: 312-21.
  15. Deberg M., Labasse A., Collette J. et al. One-year increase of Coll 2-1, a new marker of type II collagen degradation, in urine is highly predictive of radiological OA progression // Osteoarthritis Cartilage. - 2005; 13: 1059-65.
  16. Deberg M., Dubuc J., Labasse A. et al. One-year follow-up of Coll2-1, Coll2-1NO2 and myeloperoxydase serum levels in osteoarthritis patients after hip or knee replacement // Ann. Rheum. Dis. - 2008; 67: 168-74.
  17. Evcik D., Babaoglu Ü. Osteoartrit Etyopatojenezi. Saridogan M. (Editor). TanidanTedaviyeOsteoartrit / Istanbul: Nobel Tip Kitapevleri, 2007; 51-72.
  18. Jobin C., Bradham C., Russo M. et al. Curcumin blocks cytokine-mediated NF-kappa B activation and proinflammatory gene expression by inhibiting inhibitory factor I-kappa B kinase activity // J. Immunol. - 1999; 163: 3474-83.
  19. Jurenka J. Anti-inflammatory properties of curcumin, a major constituent of Curcuma longa: a review of preclinical and clinical research // Altern. Med. Rev. -2009; 14 (2): 141-53.
  20. Huebner J., Williams J., Deberg M. et al. Collagen fibril disruption occurs early in primary guinea pig knee osteoarthritis // Osteoarthritis Cartilage. - 2010; 18: 397-405.
  21. Kimmatkar N., Thawani V., Hingorani L. et al. Efficacy and tolerability of Boswelliaserrata extract in treatment of osteoarthritis of knee - A randomized double blind placebo controlled trial // Phytomedicine. - 2003; 10: 3-7.
  22. Kobayashi N., Kostka G., Garbe J. et al. A comparative analysis of the fibulin protein family. Biochemical characterization, binding interactions, and tissue localization // J. Biol. Chem. - 2007; 282: 11805-16.
  23. Meulenbelt I., Kloppenburg M., Kroon H. et al. Urinary CTX-II levels are associated with radiographic subtypes of osteoarthritis in hip, knee, hand, and facet joints in subject with familial osteoarthritis at multiple sites: the GARP study // Ann. Rheum. Dis. - 2006; 65: 360-5.
  24. Scarpellini M., Lurati A., Vignati G. et al. Biomarkers, type II collagen, glucosamine and chondroitin sulfate in osteoarthritis follow-up: the «Magenta osteoarthritis study» // J. Orthopaed. Traumatol. - 2008; 9: 81-7.
  25. Sellam J., Berenbaum F. The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis // Nat. Rev. Rheumatol. - 2010; 6: 625-35.
  26. Surh Y., Chun K., Cha H. et al. Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NFkappa B activation // Mutat Res. -2001; 480-481: 243268.
  27. Trentham D., Halpner A., Trentham R. et al. Treatment of rheumatoid arthritis using undenatured type II collagen // Original Internist. - 2002; 9: 12-5.
  28. Wei W., Zhang L., Xu J. et al. A multicenter, double-blind, randomized, controlled phase III Clinical trial of chicken type II collagen in rheumatoid arthritis // Arthritis Res. Ther. - 2009; 11: 180

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