Iron deficiency in atopy (own data and literature analysis)
- Authors: Delyagin V.M.1, Migacheva N.B.1,2
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Affiliations:
- Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology, and Immunology, Ministry of Health of Russia
- Samara State Medical University, Ministry of Health of Russia
- Issue: Vol 34, No 1 (2023)
- Pages: 33-36
- Section: From Practice
- URL: https://journals.eco-vector.com/0236-3054/article/view/397304
- DOI: https://doi.org/10.29296/25877305-2023-01-06
- ID: 397304
Cite item
Abstract
Due to systemic allergic inflammation, intestinal changes, and malnutrition, atopic diseases can be complicated by iron deficiency conditions.
Objective. To determine the values of hemoglobin (Hb) and the frequency of anemia in children and adolescents with atopic dermatitis (AD) and asthma and to present the possible causes of the disorders.
Results. In 2001, a total of 180 children (mean age 4 years) with AD were examined; their Hb concentration was 109.3±9.8 g/l; of them 77 (43%) children had <110 g/L. In the control group of 210 healthy children (mean age 4 years), their Hb level was 122.4±10.1 g/L (р<0.01). In 2019, a total of 130 children (mean age 4 years) with AD were examined; their Hb concentration was 112.0±9.7 g/L, while 9 (6.9%) children had <110 g/L. In the control group of 129 patients (mean age 4 years), their Hb concentration ran to 123.0±9.5 g/L (p = 0.05). Also in 2019, a total of 110 children (mean age 12 years) with asthma were examined; their Hb concentration was 118.0±5.5 g/L, of them 5 (4.5%) children (including 3 adolescent girls) had a Hb concentration of <110 g/L. In the control group of 98 patients, their Hb concentration was 127.0±4.2 g/L (p = 0.05). In all groups of children with atopic diseases, anemia was associated with iron deficiency.
Conclusion. The frequency of anemia among the examined children with atopy was higher than that in the general population. According to the results of the authors’ own and independent studies, iron deficiency states can result from systemic allergic inflammation with intestinal involvement, metabolic disorders, and nutritional deficiencies. Iron deficiency conditions can contribute to the development of allergy and deteriorate its course.
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About the authors
V. M. Delyagin
Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology, and Immunology, Ministry of Health of Russia
Author for correspondence.
Email: delyagin-doktor@yandex.ru
ORCID iD: 0000-0001-8149-7669
Doctor of Medical Sciences, Professor
Russian Federation, MoscowN. B. Migacheva
Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology, and Immunology, Ministry of Health of Russia; Samara State Medical University, Ministry of Health of Russia
Email: delyagin-doktor@yandex.ru
ORCID iD: 0000-0003-0941-9871
Doctor of Medical Sciences, Associate Professor
Russian Federation, Moscow; SamaraReferences
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