Flavonoids quercetin, dihydroquercetin (taxifolin): antioxidant and anti-ischemic effects, possibility of application in cardiology
- Authors: Dedov D.V.1,2, Usoltseva O.N.3
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Affiliations:
- Tver State Medical University
- Tver Regional Clinical Cardiology Centre
- Irkutsk State Medical University
- Issue: Vol 34, No 6 (2023)
- Pages: 42-44
- Section: Pharmacology
- URL: https://journals.eco-vector.com/0236-3054/article/view/524768
- DOI: https://doi.org/10.29296/25877305-2023-06-07
- ID: 524768
Cite item
Abstract
Objective. Determination of the place of flavonoids quercetin and dihydroquercetin as a preventive and auxiliary agent in the treatment of cardiovascular diseases.
Material and methods. The analysis of literature data was carried out, in which the results of studies on the use of flavonoids quercetin, dihydroquercetin (taxifolin) in animal experiments and in patients with cardiovascular diseases were presented, as well as data from experimental laboratory studies were analyzed.
Results and discussion. Flavonoids had antioxidant, antiradical, vasoprotective, antiplatelet, anti-inflammatory effects. They slow down the development of atherosclerosis and cardiovascular diseases, and are also a means of preventing fatal cardiovascular complications. The antihypertensive, anti-ischemic, antiarrhythmic, hypolipidemic, antiplatelet effect of quercetin and dihydroquercetin has been shown. The possibility of using dihydroquercetin in the complex treatment of patients with arterial hypertension is shown. The high efficiency of the drug Bio Dihydroquercetin, which is distinguished by a special author's production technology, and is a highly active dihydroquercetin, of natural origin with proven efficacy and safety, was noted. Taking dihydroquercetin is associated with a decrease in blood viscosity, a decrease in aggregation, an improvement in the deformability of red blood cells, as well as an improvement in endothelial function and tissue perfusion.
Conclusions. Flavonoids quercetin, dihydroquercetin (Dihydroquercetin) have antioxidant, vasodilator, hypotensive, antiplatelet, hypolipidemic, anti-ischemic, anti-inflammatory effects. They can be used in the comprehensive prevention and treatment of patients with cardiovascular diseases.
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About the authors
D. V. Dedov
Tver State Medical University; Tver Regional Clinical Cardiology Centre
Author for correspondence.
Email: dedov_d@inbox.ru
ORCID iD: 0000-0002-3922-3207
Doctor of Medical Sciences, Professor
Russian Federation, Tver; TverO. N. Usoltseva
Irkutsk State Medical University
Email: dedov_d@inbox.ru
ORCID iD: 0000-0002-6947-0057
Candidate of Medical Sciences
Russian Federation, IrkutskReferences
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