Relationship of comorbidity to the severity of the course of the novel coronavirus infection in patients who have delivered in a District Clinical Hospital of Khanty-Mansiysk

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Abstract

Objective. To study the structure of somatic morbidity and comorbidity in pregnant women living in the Khanty-Mansi Autonomous Area and to evaluate its impact on the severity of the course of novel coronavirus infection (NCI) and the outcomes of pregnancy.

Subjects and methods. A single-center prospective comparative study was conducted in the groups of women who experienced NCI in the third trimester from March 2020 to April 2022 (n=149). The patients were divided into groups: 1) mild NCI (without pneumonia) (n=78); 2) moderate NCI (n=52); 3) severe NCI (n=19).

Results. A statistically significant relationship was found between the presence of obesity concurrent with diseases of the urinary system, the upper respiratory tract, and severe NCI (p=0.04). Chronic pyelonephritis in the patients’ history was statistically significantly associated with oligohydramnios (p<0.001) and gestational diabetes mellitus (GDM) (95% confidence interval, 1.070–8.883).

Conclusion. Ninety (60.4%) pregnant women who had experienced NCI were found to have a history of somatic diseases; the comorbidity index was 1.9. The concurrence of endocrine and urinary diseases with chronic upper respiratory tract ones significantly worsened the course of NCI and led to placental disorders and GDM.

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E. E. Chernaya

Khanty-Mansiysk State Medical Academy

Author for correspondence.
Email: chyornayaekaterina@yandex.ru
ORCID iD: 0000-0002-9899-3279

Candidate of Medical Sciences

Russian Federation, Khanty-Mansiysk

A. E. Kasparova

Khanty-Mansiysk State Medical Academy; District Clinical Hospital

Email: chyornayaekaterina@yandex.ru
ORCID iD: 0000-0001-7665-2249

MD, Associate Professor

Russian Federation, Khanty-Mansiysk; Khanty-Mansiysk

V. L. Yanin

Khanty-Mansiysk State Medical Academy

Email: chyornayaekaterina@yandex.ru
ORCID iD: 0000-0001-5723-1246

MD, Professor

Russian Federation, Khanty-Mansiysk

E. I. Kutefa

District Clinical Hospital

Email: chyornayaekaterina@yandex.ru
ORCID iD: 0000-0003-2946-0249
Russian Federation, Khanty-Mansiysk

E. N. Vasilkovskaya

Khanty-Mansiysk State Medical Academy; District Clinical Hospital

Email: chyornayaekaterina@yandex.ru
ORCID iD: 0000-0003-1586-0532
Russian Federation, Khanty-Mansiysk; Khanty-Mansiysk

L. A. Chegus

Khanty-Mansiysk State Medical Academy; District Clinical Hospital

Email: chyornayaekaterina@yandex.ru
ORCID iD: 0000-0002-9698-8038

Candidate of Medical Sciences, Associate Professor

Russian Federation, Khanty-Mansiysk; Khanty-Mansiysk

S. I. Semenchenko

Khanty-Mansiysk State Medical Academy; District Clinical Hospital

Email: chyornayaekaterina@yandex.ru
ORCID iD: 0000-0003-1157-6753

Candidate of Medical Sciences, Associate Professor

Russian Federation, Khanty-Mansiysk; Khanty-Mansiysk

F. R. Hidirnebieva

Khanty-Mansiysk State Medical Academy

Email: chyornayaekaterina@yandex.ru
ORCID iD: 0000-0002-7356-6115
Russian Federation, Khanty-Mansiysk

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Supplementary files

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2. Fig. 1. The severity of NCI according to the experienced endocrine diseases

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3. Fig. 2. Hospital stay length in women with experienced NCI and their newborns

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