Functional status of the cardiovascular system in elderly patients with sarcopenia

封面

如何引用文章

全文:

开放存取 开放存取
受限制的访问 ##reader.subscriptionAccessGranted##
受限制的访问 订阅或者付费存取

详细

Sarcopenia is a pathological condition found in elderly patients that impairs their quality of life and increases the risks of disability.

Objective. To assess the functional state of the cardiovascular system in elderly patients with sarcopenia.

Materials and methods. The main group included patients with sarcopenia diagnosed according to the criteria of EWGSOP-2 (European Working Group on Sarcopenia in Older People 2) supplemented by the screening questionnaire SARC-F (Strength, Assistance with walking, Rising from a chair, Climbing stairs and Falls). The state of the cardiovascular system was assessed based on the results of ECG, echocardiography and duplex examination of vessels at rest.

Results. The features of the functional state of the cardiovascular system in sarcopenia were determined, which manifested themselves in the form of impaired repolarization processes and arrhythmic dysfunction, lower parameters of cerebral perfusion, and the presence of an early sign of latent heart failure.

Conclusions. The treatment of cardiovascular diseases in the elderly population requires special attention due to the polymorbidity of patients and sarcopenia should be taken into account, among other things, as a factor affecting the state of the cardiovascular system.

全文:

受限制的访问

作者简介

Iu. Samoilova

Siberian State Medical University, Ministry of Health of Russia

编辑信件的主要联系方式.
Email: samoilova_y@inbox.ru
ORCID iD: 0000-0002-2667-4842

Dr. Sci. (Med.), Profesor

 

俄罗斯联邦, Tomsk

M. Matveeva

Siberian State Medical University, Ministry of Health of Russia

Email: samoilova_y@inbox.ru
ORCID iD: 0000-0001-9966-6686

Dr. Sci. (Med.), Assistant Professor

俄罗斯联邦, Tomsk

D. Podchinenova

Siberian State Medical University, Ministry of Health of Russia

Email: samoilova_y@inbox.ru
ORCID iD: 0000-0001-6212-4568

Cand. Sci. (Med.)

俄罗斯联邦, Tomsk

Ya. Yakimova

Siberian State Medical University, Ministry of Health of Russia

Email: samoilova_y@inbox.ru
ORCID iD: 0009-0006-1151-261X
俄罗斯联邦, Tomsk

L. Shuliko

Siberian State Medical University, Ministry of Health of Russia

Email: samoilova_y@inbox.ru
ORCID iD: 0000-0001-5299-2097
俄罗斯联邦, Tomsk

V. Avkhimenko

Siberian Federal Scientific and Clinical Center, Federal Medical Biological Agency of Russia

Email: samoilova_y@inbox.ru
ORCID iD: 0000-0002-2178-601X

Cand. Sci. (Med.)

俄罗斯联邦, Seversk

D. Kudlay

I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University); M.V. Lomonosov Moscow State University; State Research Center «Institute of Immunology», Federal Biomedical Agency of Russia

Email: samoilova_y@inbox.ru
ORCID iD: 0000-0003-1878-4467

Corresponding Member of the Russian Academy of Sciences, Dr. Sci. (Med.)

俄罗斯联邦, Moscow; Moscow; Moscow

E. Starovoitova

Siberian State Medical University, Ministry of Health of Russia

Email: samoilova_y@inbox.ru

Dr. Sci. (Med.), Assistant Professor

俄罗斯联邦, Tomsk

E. Samoylov

Siberian State Medical University, Ministry of Health of Russia

Email: samoilova_y@inbox.ru
ORCID iD: 0000-0002-1807-5532
俄罗斯联邦, Tomsk

E. Khoroshunova

Siberian State Medical University, Ministry of Health of Russia

Email: samoilova_y@inbox.ru
ORCID iD: 0000-0002-3596-6732
俄罗斯联邦, Tomsk

A. Ragimov

Siberian State Medical University, Ministry of Health of Russia

Email: samoilova_y@inbox.ru
俄罗斯联邦, Tomsk

参考

  1. Damluji A., Alfaraidhy M., Al Hajri N. et al. Sarcopenia and Cardiovascular Diseases. Circulation. 2023; 147 (20): 1534–53. doi: 10.1161/CIRCULATIONAHA.123.064071
  2. Yuan S., Larsson S.C. Epidemiology of sarcopenia: Prevalence, risk factors, and consequences. Metabolism. 2023; 144: 155533. doi: 10.1016/j.metabol.2023.155533
  3. Heshmat R., Shafiee G., Ostovar A. et al. Relationship Between Sarcopenia and Electrocardiographic Abnormalities in Older People: The Bushehr Elderly Health Program. Front Med (Lausanne). 2021; 8: 656181. doi: 10.3389/fmed.2021.656181
  4. Santana N.M., Mendes R.M.L., Silva N.F.D. et al. Sarcopenia and sarcopenic obesity as prognostic predictors in hospitalized elderly patients with acute myocardial infarction. Einstein. 2019; 17: eAO4632. doi: 10.31744/einstein_journal/2019AO4632
  5. Requena Calleja M.A., Arenas Miquelez A., Diez-Manglano J. et al. Sarcopenia, frailty, cognitive impairment and mortality in elderly patients with non-valvular atrial fibrillation. Rev Clin Esp. 2019; 219: 424–32. doi: 10.1016/j.rce.2019.04.001
  6. Самойлова Ю.Г., Матвеева М.В., Хорошунова Е.А. и др. Композиционный состав тела при саркопении у лиц среднего возраста. Терапевтический архив. 2022; 94 (10): 1149–54 [Samoilova Iu.G., Matveeva M.V., Khoroshunova E.A. et al. Body composition in sarcopenia in middle-aged individuals. Terapevticheskii Arkhiv. 2022; 94 (10): 1149–54 (in Russ.)]. doi: 10.26442/00403660.2022.10.201878
  7. Cruz-Jentoft A.J., Bahat G., Bauer J. et al.; Writing Group for the European Working Group on Sarcopenia in Older People 2 (EWGSOP2), and the Extended Group for EWGSOP2. Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing. 2019; 48 (1): 16–31. doi: 10.1093/ageing/afy169 [Erratum in: Age Ageing. 2019; 48 (4): 601. doi: 10.1093/ageing/afz046].
  8. Piotrowicz K., Głuszewska A., Czesak J. et al. SARC-F as a case-finding tool for sarcopenia according to the EWGSOP2. National validation and comparison with other diagnostic standards. Aging Clin Exp Res. 2021; 33: 1821–9. doi: 10.1007/s40520-020-01782-y
  9. Саидова М.А., Авалян А.А., Ощепкова Е.В. и др. Сравнительные возможности метода спекл-трекингэхокардиографии в двумерном и трехмерном режимах в выявлении субклинической кардиотоксичности у больных раком молочной железы. Терапевтический архив. 2020; 92 (12): 142–7 [Saidova M.A., Avalyan A.A., Oshchepkova E.V. et al. Comparative capabilities of the speckle-tracking echocardiography technologiesin two-dimensional and three-dimensional modes in the detection of subclinical cardiotoxicity in patients with breast cancer. Therapeutic Archive. 2020; 92 (12): 142–7 (in Russ.)]. doi: 10.26442/00403660.2020.12.200431
  10. Авхименко В.А., Тривоженко А.Б., Гребенюк О.В. Метод динамической одномоментной допплерографии коронарного и церебрального кровотока с анализом эффективности пантовой бальнеологической терапии у пациентов с артериальной гипертонией. Медицинский алфавит. 2023; 1 (15): 36–40 [Avkhimenko V.A., Trivozhenko A.B., Grebenyuk O.V. Method of dynamic one-stage Dopplerography of coronary and cerebral blood flow with analysis of efficiency of antler balneotherapy in patients with arterial hypertension. Medical alphabet. 2023; 1 (15): 36–40 (in Russ.)]. doi: 10.33667/2078-5631-2023-15-35-40
  11. Lang R.M., Badano L.P., Bierig M. et al. Recommendations for Cardiac Chamber Quantification by Echocardiography in Adults: An Update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. J Am Soc Echocardiogr. 2015; 28: 1–39. doi: 10.1016/j.echo.2014.10.003
  12. Драпкина О.М., Будневский А.В., Овсянников Е.С. и др. Саркопеническое ожирение: закономерности и парадоксы. Профилактическая медицина. 2021; 24 (1): 73–8 [Drapkina O.M., Budnevsky A.V., Ovsyannikov E.S. et al. Sarcopenic obesity: patterns and paradoxes. Russian Journal of Preventive Medicine. 2021; 24 (1): 73–8 (in Russ.)]. doi: 10.17116/profmed20212401173
  13. Трушникова Н.С., Мальчикова С.В., Максимчук-Колобова Н.С. и др. Возрастное ремоделирование сердечно-сосудистой системы и факторы его ускорения. Вятский медицинский вестник. 2022; 2 (74): 93–8 [Trushnikova N.S., Mal'chikova S.V, Maksimchuk-Kolobova N.S. et al. Age-related remodeling of the cardiovascular system and its acceleration factors. Medical Newsletter of Vyatka. 2022; 2 (74): 93–8 (in Russ.)]. doi: 10.24412/2220-7880-2022-2-93-98
  14. Xia M.F., Chen L.Y., Wu L. et al. Sarcopenia, sarcopenic overweight/obesity and risk of cardiovascular disease and cardiac arrhythmia: A cross-sectional study. Clin Nutr. 2021; 40 (2): 571–80. doi: 10.1016/j.clnu.2020.06.003
  15. Levy D., Garrison R.J., Savage D.D. et al. Prognostic Implications of Echocardiographically Determined Left Ventricular Mass in the Framingham Heart Study. N Engl J Med. 1990; 322: 1561–6. doi: 10.1056/nejm199005313222203
  16. Lim R.M.H., Koh A.S. Cardiovascular Aging and Physical Activity: Insights From Metabolomics. Front Cardiovasc Med. 2021; 8: 728228. doi: 10.3389/fcvm.2021.728228
  17. Микаелян А.А., Вараева Ю.Р., Лискова Ю.В. и др. Саркопения и хроническая сердечная недостаточность. Часть 1. Лечебное дело. 2023; 2: 51–6 [Mikaelyan A.A., Varaeva Yu.R., Liskova YU.V. et al. Sarcopenia and chronic heart failure. Part 1. The Journal of General Medicine. 2023; 2: 51–6 (in Russ.)]. doi: 10.24412/2071-5315-2023-12879
  18. Kwon H.E., Ko N., Yuk D. et al. Improved Muscle Mass and Function With Protein Supplementation in Older Adults With Sarcopenia: A Meta-Analysis. Ann Rehabil Med. 2023; 47 (5): 358–66. doi: 10.5535/arm.23076
  19. Cheng K.Y., Chow S.K., Hung V.W. et al. Diagnosis of sarcopenia by evaluating skeletal muscle mass by adjusted bioimpedance analysis validated with dual-energy X-ray absorptiometry. J Cachexia Sarcopenia Muscle. 2021; 12 (6): 2163–73. doi: 10.1002/jcsm.12825
  20. Krzymińska-Siemaszko R., Deskur-Śmielecka E., Kaluźniak-Szymanowska A. et al. Comparison of Diagnostic Value of the SARC-F and Its Four Modified Versions in Polish Community-Dwelling Older Adults. Clin Interv Aging. 2023; 18: 783–97. doi: 10.2147/CIA.S408616
  21. Bahat G., Erbas Sacar D. SARC-F can detect sarcopenia with a high sensitivity. Aging Clin Exp Res. 2021; 33: 2017. doi: 10.1007/s40520-021-01909-9
  22. Barreto de Lima A., dos Santos Ribeiro G., Henriques-Neto D. et al. Diagnostic performance of SARC-F and SARC-CalF in screening for sarcopenia in older adults in Northern Brazil. Sci Rep. 2023; 13: 11698. doi: 10.1038/s41598-023-39002-y

补充文件

附件文件
动作
1. JATS XML
2. Example of blood flow spectrum in the middle cerebral artery: a – conditionally healthy patient (Vₚₛ=85 cm/s; RI=0.65 ); б – patient with sarcopenia (Vₚₛ=62 cm/s; RI=0.58 )

下载 (404KB)

版权所有 © Russkiy Vrach Publishing House, 2024