The influence of ABCB1 gene polymorphisms on the development of threatened preterm labor in pregnant women of the Russian population

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Abstract

Objective. To study the associations of alleles and genotypes of polymorphic markers of the ABCB1 gene with predisposition to the threatened preterm labor.

Material and methods. The study included 96 pregnant women with an established diagnosis of threatened premature birth (main group) and 87 practically healthy pregnant women with timely spontaneous labor (control group) in accordance with the inclusion/exclusion criteria. Genotyping to identify polymorphisms rs1045642 (3435C > T), rs2032582 (2677G > T), rs1128503 (1236C > T) of the ABCB1 gene was carried out by real-time PCR.

Results. The distribution of genotypes by the studied polymorphisms corresponded to the Hardy-Weinberg distribution in the control and main groups. No significant differences were found in the frequencies of alleles and genotypes of ABCB1 gene polymorphisms in the studied groups of pregnant women.

Conclusion. The studied ABCB1 gene polymorphisms are not associated with threatened preterm labor in Russian pregnant women. The allele and genotype frequencies of the rs11285503, rs2032582, and rs1045642 ABCB1 gene polymorphisms correspond to the literature data on their occurrence in the Caucasian population.

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About the authors

K. O. Akopov

Yudin City Clinical Hospital of the Moscow Department of Health

Email: rchilova@gmail.com
ORCID iD: 0000-0002-3268-481X
Russian Federation, Moscow

R. A. Chilova

Sechenov First Moscow State Medical University

Author for correspondence.
Email: rchilova@gmail.com
ORCID iD: 0000-0001-6331-3109
SPIN-code: 4137-4848

MD, Professor

Russian Federation, Moscow

E. A. Sokova

Sechenov First Moscow State Medical University

Email: rchilova@gmail.com
ORCID iD: 0000-0002-6389-2099
SPIN-code: 5550-4650

Candidate of Medical Sciences, Associate Professor

Russian Federation, Moscow

R. E. Kazakov

Scientific Centre for Expert Evaluation of Medicinal Products

Email: rchilova@gmail.com
ORCID iD: 0000-0003-0802-4229
SPIN-code: 8751-5090

Candidate of Biological Sciences

Russian Federation, Moscow

E. V. Zhukova

Sechenov First Moscow State Medical University

Email: rchilova@gmail.com
ORCID iD: 0000-0003-3949-7109
SPIN-code: 4300-8885

Candidate of Medical Sciences

Russian Federation, Moscow

M. V. Poznyak

Sechenov First Moscow State Medical University

Email: rchilova@gmail.com
ORCID iD: 0009-0006-8217-0784
Russian Federation, Moscow

M. N. Zholobova

Sechenov First Moscow State Medical University

Email: rchilova@gmail.com
ORCID iD: 0000-0003-2842-2910

Candidate of Medical Sciences

Russian Federation, Moscow

G. E. Sevastyanov

Sechenov First Moscow State Medical University

Email: rchilova@gmail.com
ORCID iD: 0009-0000-4823-9510
Russian Federation, Moscow

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