The influence of ABCB1 gene polymorphisms on the development of threatened preterm labor in pregnant women of the Russian population

封面

如何引用文章

全文:

开放存取 开放存取
受限制的访问 ##reader.subscriptionAccessGranted##
受限制的访问 订阅或者付费存取

详细

Objective. To study the associations of alleles and genotypes of polymorphic markers of the ABCB1 gene with predisposition to the threatened preterm labor.

Material and methods. The study included 96 pregnant women with an established diagnosis of threatened premature birth (main group) and 87 practically healthy pregnant women with timely spontaneous labor (control group) in accordance with the inclusion/exclusion criteria. Genotyping to identify polymorphisms rs1045642 (3435C > T), rs2032582 (2677G > T), rs1128503 (1236C > T) of the ABCB1 gene was carried out by real-time PCR.

Results. The distribution of genotypes by the studied polymorphisms corresponded to the Hardy-Weinberg distribution in the control and main groups. No significant differences were found in the frequencies of alleles and genotypes of ABCB1 gene polymorphisms in the studied groups of pregnant women.

Conclusion. The studied ABCB1 gene polymorphisms are not associated with threatened preterm labor in Russian pregnant women. The allele and genotype frequencies of the rs11285503, rs2032582, and rs1045642 ABCB1 gene polymorphisms correspond to the literature data on their occurrence in the Caucasian population.

全文:

受限制的访问

作者简介

K. Akopov

Yudin City Clinical Hospital of the Moscow Department of Health

Email: rchilova@gmail.com
ORCID iD: 0000-0002-3268-481X
俄罗斯联邦, Moscow

R. Chilova

Sechenov First Moscow State Medical University

编辑信件的主要联系方式.
Email: rchilova@gmail.com
ORCID iD: 0000-0001-6331-3109
SPIN 代码: 4137-4848

MD, Professor

俄罗斯联邦, Moscow

E. Sokova

Sechenov First Moscow State Medical University

Email: rchilova@gmail.com
ORCID iD: 0000-0002-6389-2099
SPIN 代码: 5550-4650

Candidate of Medical Sciences, Associate Professor

俄罗斯联邦, Moscow

R. Kazakov

Scientific Centre for Expert Evaluation of Medicinal Products

Email: rchilova@gmail.com
ORCID iD: 0000-0003-0802-4229
SPIN 代码: 8751-5090

Candidate of Biological Sciences

俄罗斯联邦, Moscow

E. Zhukova

Sechenov First Moscow State Medical University

Email: rchilova@gmail.com
ORCID iD: 0000-0003-3949-7109
SPIN 代码: 4300-8885

Candidate of Medical Sciences

俄罗斯联邦, Moscow

M. Poznyak

Sechenov First Moscow State Medical University

Email: rchilova@gmail.com
ORCID iD: 0009-0006-8217-0784
俄罗斯联邦, Moscow

M. Zholobova

Sechenov First Moscow State Medical University

Email: rchilova@gmail.com
ORCID iD: 0000-0003-2842-2910

Candidate of Medical Sciences

俄罗斯联邦, Moscow

G. Sevastyanov

Sechenov First Moscow State Medical University

Email: rchilova@gmail.com
ORCID iD: 0009-0000-4823-9510
俄罗斯联邦, Moscow

参考

  1. Talati A.N., Hackney D.N., Mesiano S. Pathophysiology of preterm labor with intact membranes. Semin Perinatol. 2017; 41 (7): 420–6. doi: 10.1053/j.semperi.2017.07.013
  2. Coler B.S., Shynlova O., Boros-Rausch A. et al. Landscape of Preterm Birth Therapeutics and a Path Forward. J Clin Med. 2021; 10: 2912. doi: 10.3390/jcm10132912
  3. Gondane P., Kumbhakarn S., Maity P. et al. Recent Advances and Challenges in the Early Diagnosis and Treatment of Preterm Labor. Bioengineering. 2024; 11 (2): 161. doi: 10.3390/bioengineering11020161
  4. Plunkett J., Borecki I., Morgan T. et al. Populationbased estimate of sibling risk for preterm birth, preterm premature rupture of membranes, placental abruption and pre-eclampsia. BMC Genet. 2008; 9: 44. doi: 10.1186/1471-2156-9-44
  5. Казаков Р.Е., Чилова Р.А., Акопов К.О. и др. Полиморфизм гена ADRB2 и состояние угрозы преждевременных родов. Фармакогенетика и фармакогеномика. 2021; 1: 9–17 [Kazakov R., Chilova R., Akopov K. et al. ADRB2 gene polymorphism and preterm labor. Pharmacogenetics and pharmacogenomics. 2021; 1: 9–17 (in Russ.)]. doi: 10.37489/2588-0527-2021-1-9-17
  6. Bloise E., Ortiga-Carvalho T.M., Reis F.M. et al. ATP-binding cassette transporters in reproduction: a new frontier. Hum Reprod Update. 2016; 22: 164–81. doi: 10.1093/humupd/dmv049
  7. Kozlosky D., Barrett E., Aleksunes L.M. Regulation of Placental Efflux Transporters during Pregnancy Complications. Drug Metab Dispos. 2022; 50: 1364–75. doi: 10.1124/dmd.121.000449
  8. Michael A.E. Potential significance of physiological and pharmacological glucocorticoids in early pregnancy. Hum Reprod Update. 2008; 14 (5): 497–517. doi: 10.1093/humupd/dmn021
  9. Ieiri I. Functional significance of genetic polymorphisms in P-glycoprotein (MDR1, ABCB1) and Breast cancer resistamce protein (BCRP, ABCG2). Drug Metab Pharmacokinet. 2012; 27 (1): 85–105. doi: 10.2133/dmpk.dmpk-11-rv-098
  10. Manuck TA. Pharmacogenomics of preterm birth prevention and treatment. BJOG. 2016; 123 (3): 368–75. doi: 10.1111/1471-0528.13744
  11. WHO recommendation on tocolytic therapy for improving preterm birth outcomes. Geneva: World Health Organization, 2022.
  12. Клинические рекомендации «Преждевременные роды» (утв. Минздравом России) [Clinical guidelines «Preterm birth» (approved by the Ministry of Health of Russia) (in Russ.)]. URL: http://cr.rosminzdrav.ru/
  13. WHO, Preterm birth, 10.05.2023. URL: https://www.who.int/news-room/fact-sheets/detail/preterm-birth
  14. Cascorbi I. P-glycoprotein: tissue distribution, substrates, and functional consequences of genetic variations. Handb Exp Pharmacol. 2011; 201: 261–83. doi: 10.1007/978-3-642-14541-4_6
  15. Сычев Д.А., Леванов А.Н., Шелехова Т.В. и др. Влияние полиморфизма генов ABCB1 и CES1 на уровни равновесных концентраций дабигатрана у пациентов после эндопротезирования коленного сустава. Атеротромбоз. 2018; 1: 122–30 [Sychev D., Levanov А., Shelekhova T. et al. Impact of ABCB1 and CES1 genetic polymorphisms on trough steady-state dabigatran concentrations in patients after endoprosthesis of knife join. Atherothrombosis. 2018; 1: 122–30 (in Russ.)]. doi: 10.21518/2307-1109-2018-1-122-130

补充文件

附件文件
动作
1. JATS XML
下载

版权所有 © Russkiy Vrach Publishing House, 2025