Interrelation of neutrophilic hematopoiesis, systemic inflammation and gastrointestinal microbiocenosis in wounded patients with traumatic disease

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Purpose. To study the indicators of intestinal microbiots, the characteristics of neutrophilic granulocytes of peripheral blood and markers of systemic inflammation in patients with political studies.

Material and methods. The study was attended by 36 patients with political studies. The composition of the intestinal microbiots was analyzed by the 16s RRNK sequencing method, the correlation by the criterion of the syllaben was studied depending on the type of intestinal microorganisms and the content of neutrophilic granulocytes of peripheral blood, the polynomial dependence of the amount of neutrophilic myelocytes and segmented neutrophils on the size of C-reactive squirrel, the level Protrombin index and concentration of fibrinogen.

Results. Reliable correlation relationships between the content of granulocytic sprout cells and representatives of the types of microbial intestinal flora were identified. It was established that the number of types of microorganisms, reliably interconnected with the level of granulocytes, decreases with an increase in cell maturity. The relationship between markers of systemic inflammation and the degree of maturity of granulocytes was revealed.

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作者简介

I. Potapova

S.M. Kirov Military Medical Academy, Ministry of Defense of Russia

编辑信件的主要联系方式.
Email: seliverstov-pv@yandex.ru
ORCID iD: 0009-0004-6129-1996
SPIN 代码: 3685-2664

Associate Professor, Candidate of Medical Sciences

俄罗斯联邦, Saint Petersburg

E. Chiglintceva

City Hospital No. 40 of Kurortnyi region

Email: seliverstov-pv@yandex.ru
ORCID iD: 0009-0006-6619-9798
俄罗斯联邦, Saint Petersburg

N. Volga

S.M. Kirov Military Medical Academy, Ministry of Defense of Russia

Email: seliverstov-pv@yandex.ru
ORCID iD: 0009-0005-1945-6539
SPIN 代码: 7273-4168

Candidate of Medical Sciences

 

俄罗斯联邦, Saint Petersburg

Iu. Kravchuk

S.M. Kirov Military Medical Academy, Ministry of Defense of Russia

Email: seliverstov-pv@yandex.ru
ORCID iD: 0000-0001-8347-0531
SPIN 代码: 6767-5189

Professor, MD

俄罗斯联邦, Saint Petersburg

V. Grinevich

S.M. Kirov Military Medical Academy, Ministry of Defense of Russia

Email: seliverstov-pv@yandex.ru
ORCID iD: 0000-0002-1095-8787
SPIN 代码: 1178-0242

Professor, MD

俄罗斯联邦, Saint Petersburg

参考

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2. Fig. 1. Analysis of polynomial dependence of: a – neutrophil myelocytes on CRP value; б – segmented neutrophils on CRP value

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3. Fig. 2. Analysis of polynomial dependence of neutrophil myelocytes: a – on the level of ferritin; б – on the level of prothrombin index; в – on the level of fibrinogen concentration

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4. Fig. 3. Analysis of polynomial dependence of metamyelocytes on the level of ferritin

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5. Fig. 4. Analysis of polynomial dependence of band neutrophil: a – on the level of ferritin; б – on the level of prothrombin index; в – on the level of fibrinogen concentration

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6. Fig. 5. Analysis of polynomial dependence of segmented neutrophil: a – on the level of ferritin; б – on the level of prothrombin index; в – on the level of fibrinogen concentration

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