Features of patients with infertility against the background of metabolic syndrome
- Authors: Maslov S.S.1, Chilova R.A.1, Siordia A.A.1, Zholobova M.N.1, Kovalev M.I.1, Gadaeva I.V.1, Kazakov R.E.2, Sokova E.A.1,2
-
Affiliations:
- I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)
- Scientific Centre for Expert Evaluation of Medicinal Products, Ministry of Health of Russia
- Issue: Vol 36, No 7 (2025)
- Pages: 78-80
- Section: From Practice
- URL: https://journals.eco-vector.com/0236-3054/article/view/689873
- DOI: https://doi.org/10.29296/25877305-2025-07-13
- ID: 689873
Cite item
Abstract
Metabolic syndrome negatively affects the quality of life of patients, leads to infertility and, therefore, a decrease in the birth rate. Features of patients with infertility against the background of metabolic syndrome are considered.
Full Text

About the authors
S. S. Maslov
I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)
Author for correspondence.
Email: rtchilova@gmail.com
ORCID iD: 0009-0007-1215-1059
Russian Federation, Moscow
R. A. Chilova
I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)
Email: rtchilova@gmail.com
ORCID iD: 0000-0001-6331-3109
SPIN-code: 4137-4848
Professor, MD
Russian Federation, MoscowA. A. Siordia
I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)
Email: rtchilova@gmail.com
ORCID iD: 0000-0002-8796-6443
SPIN-code: 5610-4780
Candidate of Medical Sciences
Russian Federation, MoscowM. N. Zholobova
I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)
Email: rtchilova@gmail.com
ORCID iD: 0000-0003-2842-2910
Professor, MD
Russian Federation, MoscowM. I. Kovalev
I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)
Email: rtchilova@gmail.com
ORCID iD: 0000-0002-0426-587X
SPIN-code: 2539-6420
Professor, MD
Russian Federation, MoscowI. V. Gadaeva
I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)
Email: rtchilova@gmail.com
ORCID iD: 0000-0003-0144-4984
SPIN-code: 9593-1990
Associate Professor, Candidate of Medical Sciences
Russian Federation, MoscowR. E. Kazakov
Scientific Centre for Expert Evaluation of Medicinal Products, Ministry of Health of Russia
Email: rtchilova@gmail.com
ORCID iD: 0000-0003-0802-4229
SPIN-code: 8751-5090
Candidate of Medical Sciences
Russian Federation, MoscowE. A. Sokova
I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University); Scientific Centre for Expert Evaluation of Medicinal Products, Ministry of Health of Russia
Email: rtchilova@gmail.com
ORCID iD: 0000-0002-6389-2099
SPIN-code: 5550-4650
Candidate of Medical Sciences
Russian Federation, Moscow; MoscowReferences
- Carson S.A., Kallen A.N. Diagnosis and Management of Infertility: A Review. JAMA. 2021; 326 (1): 65–76. doi: 10.1001/jama.2021.4788
- Broughton D.E., Moley K.H. Obesity and female infertility: potential mediators of obesity's impact. Fertil Steril. 2017; 107 (4): 840–7. doi: 10.1016/j.fertnstert.2017.01.017
- Talmor A., Dunphy B. Female obesity and infertility. Best Pract Res Clin Obstet Gynaecol. 2015; 29 (4): 498–506. doi: 10.1016/j.bpobgyn.2014.10.014
- Ennab F. Atiomo W. Obesity and female infertility. Best Pract Res Clin Obstet Gynaecol. 2023; 89: 102336. doi: 10.1016/j.bpobgyn.2023.102336
- Chen C.-I., Hsu M.-I., Lin S.-H. et al. Adiponectin and leptin in overweight/obese and lean women with polycystic ovary syndrome. Gynecol Endocrinol. 2015; 31 (4): 264–8. doi: 10.3109/09513590.2014.984676
- van der Steeg J.W., Steures P., Eijkemans M.J.C. et al. Obesity affects spontaneous pregnancy chances in subfertile, ovulatory women. Hum Reprod. 2008; 23 (2): 324–8. doi: 10.1093/humrep/dem371
- Silvestris E., de Pergola G., Rosania R. et al.Obesity as disruptor of the female fertility. Reprod Biol Endocrinol. 2018; 16 (1): 22. doi: 10.1186/s12958-018-0336-z
- McCartney C.R., Marshall J.C. Clinical Practice. Polycystic Ovary Syndrome. N Engl J Med. 2016; 375 (1): 54–64. doi: 10.1056/NEJMcp1514916
- Gesink Law D.C., Maclehose R.F., Longnecker M.P. Obesity and time to pregnancy. Hum Reprod. 2007; 22 (2): 414–20. doi: 10.1093/humrep/del400
- Pascuali N., Scotti L., Di Pietro M. et al. Ceramide-1-phosphate has protective properties against cyclophosphamide-induced ovarian damage in a mice model of premature ovarian failure. Hum Reprod. 2018; 33 (5): 844–59. doi: 10.1093/humrep/dey045
- Vilmann L.S., Thisted E., Baker J.L. et al. Development of obesity and polycystic ovary syndrome in adolescents. Horm Res Paediatr. 2012; 78 (5-6): 269–78. doi: 10.1159/000345310
- Barrea L., Muscogiuri G., Pugliese G. et al. Metabolically Healthy Obesity (MHO) vs. Metabolically Unhealthy Obesity (MUO) Phenotypes in PCOS: Association with Endocrine-Metabolic Profile, Adherence to the Mediterranean Diet, and Body Composition. Nutrients. 2021; 13 (11): 3925. doi: 10.3390/nu13113925
- Bright K., Dube L., Hayden K.A. et al. Effectiveness of psychological interventions on mental health, quality of life and relationship satisfaction for individuals and/or couples undergoing fertility treatment: a systematic review and meta-analysis protocol. BMJ Open. 2020; 10 (7): e036030. doi: 10.1136/bmjopen-2019-036030
- Хабибулина М.М., Елистратов Д.Г. Психокоррекционая терапия пациенток с «метаболически здоровым» ожирением. Врач. 2024; 35 (4): 36–41 [Khabibulina M., Elistratov D. Psycho-correction therapy of patients with «metabolically healthy» obesity. Vrach. 2024; 35 (4): 36–41 (in Russ.)]. doi: 10.29296/25877305-2024-04-07
Supplementary files
