Microbiota of the uterus cavity: pathology and (or) norm

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Abstract

The presence of a normal uterine microbiome is consistent with the general understanding of the existence of a human microbiome, and thus the uterine microbiota likely plays a previously unrecognized role in uterine physiology and in influencing human reproduction. It was determined that the female genital tract contains its own microbiome, which accounts for 9% of the total number of microorganisms. It was noted that the distribution of the microbiome within the female genital tract is very heterogeneous and has certain patterns. The pathophysiological effects of the uterine microbiome on the endometrial epithelium were determined. The factors determining the state of the microflora of the female genital tract were identified. It was concluded that a healthy uterine microbiome can be corrected or restored by using live biotherapeutic products or promoting the growth of these bacteria through diet (prebiotics) in an attempt to improve human health and fertility. In contrast, identification of dysbiotic profiles associated with a specific pathological condition could potentially be used as microbial biomarkers of poor reproductive health.

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About the authors

O. S. Arnt

Saint Petersburg State Pediatric Medical University, Ministry of Health of Russia

Email: drossolko@mail.ru
ORCID iD: 0000-0003-1565-2012
SPIN-code: 1482-0917

Candidate of Medical Sciences

Russian Federation, Saint Petersburg

I. V. Gorelova

V.A. Almazov National Medical Research Center, Ministry of Health of Russia

Email: drossolko@mail.ru
ORCID iD: 0000-0002-6098-1491
SPIN-code: 1207-5705

Candidate of Medical Sciences

Russian Federation, Saint Petersburg

D. S. Rossolko

Saint Petersburg State Pediatric Medical University, Ministry of Health of Russia

Author for correspondence.
Email: drossolko@mail.ru
ORCID iD: 0009-0002-1488-0582
SPIN-code: 4114-4936

Candidate of Medical Sciences

Russian Federation, Saint Petersburg

P. Zvereva

Saint Petersburg State Pediatric Medical University, Ministry of Health of Russia

Email: drossolko@mail.ru
Russian Federation, Saint Petersburg

I. A. Efimov

Saint Petersburg State Pediatric Medical University, Ministry of Health of Russia

Email: drossolko@mail.ru
SPIN-code: 2263-2382
Russian Federation, Saint Petersburg

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Supplementary files

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2. Fig. 1. Factors determining the state of the microflora of the female genital tract [8]

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3. Fig. 2. Proposed pathophysiological influence of the uterine microbiome on the endometrial epithelium (description in text) [23]

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