Microbiota of the uterus cavity: pathology and (or) norm

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The presence of a normal uterine microbiome is consistent with the general understanding of the existence of a human microbiome, and thus the uterine microbiota likely plays a previously unrecognized role in uterine physiology and in influencing human reproduction. It was determined that the female genital tract contains its own microbiome, which accounts for 9% of the total number of microorganisms. It was noted that the distribution of the microbiome within the female genital tract is very heterogeneous and has certain patterns. The pathophysiological effects of the uterine microbiome on the endometrial epithelium were determined. The factors determining the state of the microflora of the female genital tract were identified. It was concluded that a healthy uterine microbiome can be corrected or restored by using live biotherapeutic products or promoting the growth of these bacteria through diet (prebiotics) in an attempt to improve human health and fertility. In contrast, identification of dysbiotic profiles associated with a specific pathological condition could potentially be used as microbial biomarkers of poor reproductive health.

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作者简介

O. Arnt

Saint Petersburg State Pediatric Medical University, Ministry of Health of Russia

Email: drossolko@mail.ru
ORCID iD: 0000-0003-1565-2012
SPIN 代码: 1482-0917

Candidate of Medical Sciences

俄罗斯联邦, Saint Petersburg

I. Gorelova

V.A. Almazov National Medical Research Center, Ministry of Health of Russia

Email: drossolko@mail.ru
ORCID iD: 0000-0002-6098-1491
SPIN 代码: 1207-5705

Candidate of Medical Sciences

俄罗斯联邦, Saint Petersburg

D. Rossolko

Saint Petersburg State Pediatric Medical University, Ministry of Health of Russia

编辑信件的主要联系方式.
Email: drossolko@mail.ru
ORCID iD: 0009-0002-1488-0582
SPIN 代码: 4114-4936

Candidate of Medical Sciences

俄罗斯联邦, Saint Petersburg

P. Zvereva

Saint Petersburg State Pediatric Medical University, Ministry of Health of Russia

Email: drossolko@mail.ru
俄罗斯联邦, Saint Petersburg

I. Efimov

Saint Petersburg State Pediatric Medical University, Ministry of Health of Russia

Email: drossolko@mail.ru
SPIN 代码: 2263-2382
俄罗斯联邦, Saint Petersburg

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补充文件

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2. Fig. 1. Factors determining the state of the microflora of the female genital tract [8]

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3. Fig. 2. Proposed pathophysiological influence of the uterine microbiome on the endometrial epithelium (description in text) [23]

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