Dopplerometry indicators in the maternal renal and ophthalmic arteries as possible predictors of preeclampsia development during early prenatal screening

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Abstract

Objective. To identify the peculiarities of Dopplerometric indices of blood flow in the interlobular renal and ophthalmic arteries in pregnant women at 11–14 weeks of gestation at low and high risk of pre-eclampsia development, calculated in the Astrea software.

Material and methods. The study included 353 pregnant women who were divided into 2 groups: those at high risk of preeclampsia (n=44) and those at low risk of preeclampsia (n=309). The results of clinical, laboratory and instrumental examinations (Doppler parameters in the ocular and renal arteries) were compared in patients of the two groups.

Results. There were no statistically significant differences in Dopplerometric parameters of ophthalmic and renal blood flow in patients with high and low risk of preeclampsia.

Conclusions. Ophthalmic and renal blood flow doppler parameters assessed during early prenatal screening cannot serve as additional prognostic markers. We plan to study these parameters in the II trimester of pregnancy, and perform the final analysis of the results after the implementation of pregnancy complications and obtaining information on perinatal outcomes.

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About the authors

M. M. Bulanova

M.V. Lomonosov Moscow State University; Perinatal Centre of L.A. Vorohobov City Clinical Hospital No. 67 of the Moscow City Health Department

Author for correspondence.
Email: mariabulanova98@gmail.com
ORCID iD: 0000-0002-9569-3334
SPIN-code: 6062-0083
Russian Federation, Moscow

V. V. Shamugiya

Perinatal Centre of L.A. Vorohobov City Clinical Hospital No. 67 of the Moscow City Health Department

Email: mariabulanova98@gmail.com
ORCID iD: 0009-0008-6757-7660
Russian Federation, Moscow

O. B. Panina

M.V. Lomonosov Moscow State University

Email: mariabulanova98@gmail.com
ORCID iD: 0000-0003-1397-6208
SPIN-code: 2105-6871

Professor, MD

Russian Federation, Moscow

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Supplementary files

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2. Fig. 1. Dopplerogram of blood flow of the ocular artery of the left eye (control volume is placed on the projection of the investigated vessel)

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3. Fig. 2. Frequency of normal, overweight and obesity in groups of pregnant women at low and high risk of preeclampsia development

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4. Fig. 3. Frequency of PR>0.65 in groups of pregnant women at low and high risk of preeclampsia

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5. Fig. 4. Dopplerograms of ocular artery blood flow in three pregnant women in the first trimester: a – typical P2 and DV ratio; б – sharp difference between P2 and DV; в – no difference in velocity between P2 and DV

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