Dopplerometry indicators in the maternal renal and ophthalmic arteries as possible predictors of preeclampsia development during early prenatal screening

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Objective. To identify the peculiarities of Dopplerometric indices of blood flow in the interlobular renal and ophthalmic arteries in pregnant women at 11–14 weeks of gestation at low and high risk of pre-eclampsia development, calculated in the Astrea software.

Material and methods. The study included 353 pregnant women who were divided into 2 groups: those at high risk of preeclampsia (n=44) and those at low risk of preeclampsia (n=309). The results of clinical, laboratory and instrumental examinations (Doppler parameters in the ocular and renal arteries) were compared in patients of the two groups.

Results. There were no statistically significant differences in Dopplerometric parameters of ophthalmic and renal blood flow in patients with high and low risk of preeclampsia.

Conclusions. Ophthalmic and renal blood flow doppler parameters assessed during early prenatal screening cannot serve as additional prognostic markers. We plan to study these parameters in the II trimester of pregnancy, and perform the final analysis of the results after the implementation of pregnancy complications and obtaining information on perinatal outcomes.

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作者简介

M. Bulanova

M.V. Lomonosov Moscow State University; Perinatal Centre of L.A. Vorohobov City Clinical Hospital No. 67 of the Moscow City Health Department

编辑信件的主要联系方式.
Email: mariabulanova98@gmail.com
ORCID iD: 0000-0002-9569-3334
SPIN 代码: 6062-0083
俄罗斯联邦, Moscow

V. Shamugiya

Perinatal Centre of L.A. Vorohobov City Clinical Hospital No. 67 of the Moscow City Health Department

Email: mariabulanova98@gmail.com
ORCID iD: 0009-0008-6757-7660
俄罗斯联邦, Moscow

O. Panina

M.V. Lomonosov Moscow State University

Email: mariabulanova98@gmail.com
ORCID iD: 0000-0003-1397-6208
SPIN 代码: 2105-6871

Professor, MD

俄罗斯联邦, Moscow

参考

  1. James P.R., Nelson-Piercy C. Management of Hypertension before, during, and after Pregnancy. Heart. 2004; 90 (12): 1499–504. doi: 10.1136/hrt.2004.035444
  2. Клинические рекомендации Российского общества акушеров-гинекологов. Преэклампсия. Эклампсия. Отеки, протеинурия и гипертензивные расстройства во время беременности, в родах и послеродовом периоде. 2023; с. 1–54 [Clinical Recommendations of the Russian Society of Obstetricians and Gynecologists. Preeclampsia. Eclampsia. Edema, proteinuria and hypertensive disorders during pregnancy, labor and postpartum period. 2023; p. 1–54 (in Russ.)].
  3. Kuklina E.V., Ayala C., Callaghan W.M. Hypertensive disorders and severe obstetric morbidity in the United States. Obstet Gynecol. 2009; 113 (6): 1299–306. doi: 10.1097/AOG.0b013e3181a45b25
  4. Сидорова И.С., Никитина Н.А., Филиппов О.С. и др. Решенные и нерешенные вопросы преэклампсии по результатам анализа материнской смертности за последние 10 лет. Акушерство и гинекология. 2021; 4: 64–74 [Sidorova I.S., Nikitina N.A., Filippov O.S. et al. Current issues in preeclampsia: a ten-year analysis of maternal mortality. Obstetrics and Gynecology. 2021; 4: 64–74 (in Russ.)]. doi: 10.18565/aig.2021.4.64-74
  5. Клинические рекомендации Российского общества акушеров-гинекологов. Нормальная Беременность. 2025; с. 1–90 [Clinical Recommendations of the Russian Society of Obstetricians and Gynecologists. Normal Pregnancy. 2025; р. 1–90 (in Russ.)].
  6. Orosz L., Orosz G., Veress L. et al. Screening for preeclampsia in the first trimester of pregnancy in routine clinical practice in Hungary. J Biotechnol. 2019; 300 (January): 11–9. doi: 10.1016/j.jbiotec.2019.04.017
  7. Prasad S., Sahota D.S., Vanamail P. et al. Performance of Fetal Medicine Foundation Algorithm for First Trimester Preeclampsia Screening in an Indigenous South Asian Population. BMC Pregnancy Childbirth. 2021; 21 (1): 1–7. doi: 10.1186/s12884-021-04283-6
  8. Cuenca-Gómez D., De Paco Matallana C., Rolle V. et al. Comparison of different methods of first-trimester screening for preterm pre-eclampsia: cohort study. Ultrasound Obstet Gynecol. 2024; 64 (1): 57–64. doi: 10.1002/uog.27622
  9. Gurgel Alves J.A., Praciano De Sousa P.C., Bezerra Maia E Holanda Moura S. et al. First-Trimester maternal ophthalmic artery doppler analysis for prediction of pre-eclampsia. Ultrasound Obstet Gynecol. 2014; 44 (4): 411–8. doi: 10.1002/uog.13338
  10. Nicolaides K.H., Sarno M., Wright A. Ophthalmic artery doppler in the prediction of preeclampsia. Am J Obstet Gynecol. 2022; 226 (2): S1098–S1101. doi: 10.1016/j.ajog.2020.11.039
  11. Gana N., Sarno M., Vieira N. et al. Ophthalmic artery doppler at 11–13 weeks’ gestation in prediction of pre-eclampsia. Ultrasound Obstet Gynecol. 2022; 59 (6): 731–6. doi: 10.1002/uog.24914
  12. Kalafat E., Laoreti A., Khalil A. et al. Ophthalmic artery doppler for prediction of pre-eclampsia: systematic review and meta-analysis. Ultrasound Obstet Gynecol. 2018; 51 (6): 731–7. doi: 10.1002/uog.19002
  13. Марьянова Т.А., Чечнева М.А., Климова И.В. и др. Ультразвуковая диагностика допплерометрическая оценка почечного кровотока при ренальной патологии: хронической болезни почек и преэкламсии. Поликлиника. 2015; 6: 36–9 [Maryanova T.A., Chechneva M.A., Klimova I.V. et al. Doppler of renal blood flow in renal pathology: chronic kidney disease and preeclampsia. Poliklinika. 2015; 6: 36–9 (in Russ.)].
  14. Шехтман М.М. Заболевания почек и беременность. Библиотека практического врача. Актуальные вопросы акушерства и гинекологии. М.: Медицина, 1980; 184 с. [Shechtman M.M. Kidney disease and pregnancy. Library of a practical doctor. Actual issues of obstetrics and gynecology. Moscow: Meditsina, 1980; 184 p. (in Russ.)].
  15. Фрейдин А.О., Климкин А.С., Петров С.В. Гемодинамические особенности почечного кровотока в i триместре физиологически протекающей беременности. Трудный пациент. 2015; 13 (8-9): 10–1 [Freydin A.O., Klimkin A.S., Petrov S.V. Hemodynamic Features of Renal Blood Flow in the First Trimester of Physiological Pregnancy. Trudniy patsient. 2015; 13 (8-9): 10–1 (in Russ.)].
  16. Окладников С.М., Никитина С.Ю., Андреев Е.М. и др. Демографический Ежегодник России 2023. Статистический сборник. М.: Росстат, 2023; с. 88–91 [Okladnikov S.M., Nikitina S.Y., Andreev E.M. et al. Demographic Yearbook of Russia 2023. Statistical Collection. Moscow: Rosstat, 2023; pp. 88–91 (in Russ.)].
  17. Gy Lau K., Bednorz M., Parisi N., et al. Ophthalmic artery doppler in women with hypertensive disorders of pregnancy: relationship to blood pressure control and renal dysfunction at 6–9 weeks postnatally. Ultrasound Obstet Gynecol. 2024; 63 (6): 738–45. doi: 10.1002/uog.27563
  18. Yang Y., Le Ray I., Zhu J. et al. Preeclampsia prevalence, risk factors, and pregnancy outcomes in Sweden and China. JAMA Netw Open. 2021; 4 (5): e218401. doi: 10.1001/jamanetworkopen.2021.8401
  19. Верзакова И.В., Сетоян М.А. Дуплексное сканирование почек у здоровых беременных. Медицинский вестник Башкортостана. 2008; 5: 54–7 [Verzakova I.V., Setoyan M.A. Duplex scanning of kidneys in healthy pregnant women. Medical Bulletin of Bashkortostan. 2008; 5: 54–7 (in Russ.)].
  20. Dib F.R., Duarte G., Sala M.M. et al. prospective evaluation of renal artery resistance and pulsatility indices in normal pregnant women. Ultrasound Obstet Gynecol. 2003; 22 (5): 515–9. doi: 10.1002/uog.240
  21. Markovic V.M., Mikovic Z., Djukic M. et al. Doppler parameters of maternal renal blood flow in normal pregnancy. Clin Exp Obstet Gynecol. 2013; 40 (1): 70–3.
  22. Шифман Е.М., Храмченко Н.В. Состояние гемодинамики глазных артерий и верхних глазных вен у женщин. РМЖ. 2013; 2: 20–3 [Shifman E.M., Khramchenko N.V. State of hemodynamics of ocular arteries and upper ocular veins in women. RMJ. 2013; 2: 20–3 (in Russ.)].
  23. Gurgel Alves J.A., Brennecke S.P., da Silva Costa F. OS088. First trimester triple vascular test for pre-eclampsia prediction. Pregnancy Hypertens. 2012; 2 (3): 226. doi: 10.1016/j.preghy.2012.04.089
  24. Gurgel Alves J.A., Maia e Holanda Moura S.B., Araujo E. et al. Predicting small for gestational age in the first trimester of pregnancy using maternal ophthalmic artery doppler indices. J Mater Fetal Neonatal Med. 2016; 29 (7): 1190–4. doi: 10.3109/14767058.2015.1040755
  25. Kusuma R.A., Nurdiati D.S., Al Fattah A.N. et al. Ophthalmic artery doppler for pre-eclampsia prediction at the first trimester: a Bayesian survival-time model. J Ultrasound. 2023; 26 (1): 155–62. doi: 10.1007/s40477-022-00697-w
  26. Фрейдин А., Климкин А., Петров С. Изменение ренометрических показателей и индекса резистентности почечных артерий при беременности, осложненной преэклампсией. Врач. 2016; 10: 62–6 [Freidin A., Klimkin A., Petrov S. A change in renometric indicators and renal arterial resistive index in pregnancy complicated by preeclampsia. Vrach. 2016; 10: 62–6 (in Russ.)].
  27. Bellos I., Pergialiotis V. Doppler parameters of renal hemodynamics in women with preeclampsia: a systematic review and meta-analysis. J Clin Hypertens. 2020; 22 (7): 1134–44. doi: 10.1111/jch.13940
  28. Ахмедов Ф.К., Туксанова Д.И., Аваков В.Е. и др. Особенности почечного и печеночного кровотока у беременных с преэклампсией. Международный журнал прикладных и фундаментальных исследований. 2013; (7): 47–50 [Akhmedov F.K., Tuksanova D.I., Avakov V.E. et al. Features renal and hepatic blood flow in pregnant on preeclampsia. International Journal of Applied and Fundamental Research. 2013; (7): 47–50 (in Russ.)].

补充文件

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1. JATS XML
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2. Fig. 1. Dopplerogram of blood flow of the ocular artery of the left eye (control volume is placed on the projection of the investigated vessel)

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3. Fig. 2. Frequency of normal, overweight and obesity in groups of pregnant women at low and high risk of preeclampsia development

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4. Fig. 3. Frequency of PR>0.65 in groups of pregnant women at low and high risk of preeclampsia

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5. Fig. 4. Dopplerograms of ocular artery blood flow in three pregnant women in the first trimester: a – typical P2 and DV ratio; б – sharp difference between P2 and DV; в – no difference in velocity between P2 and DV

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