Arterial hypertension as a risk factor for pre-disease and disease in the domain approach in elderly patients

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Objective. To study the relationship between arterial hypertension (AH) and age-associated conditions within the domain approach.

Material and methods. 100 female patients with AH at the age of 70 years were examined. The studied parameters included the characteristics of somatic health (anthropometry, blood pressure [BP], pulse, general blood analysis, ratio of neutrophils to lymphocytes, platelets to lymphocytes, blood biochemical parameters, glomerular filtration rate, echocardiography, electrocardiography, drug therapy), parameters of the musculoskeletal system (FRAIL, Katz scales, SARC-F questionnaire, hand compression force, bioimpedanceometry), indicators of the sensory (ophthalmologic examination), cognitive (MMSE test), psychological (Beck scale, asthenic state scale [ASAS]), nutritional (MNA scale) systems.

Results. Patients with AH (systolic BP – 175 mm Hg, diastolic BP – 94 mm Hg), excessive body weight (body mass index – 37.1 kg/m2) and abdominal obesity (waist-to-hip ratio – 0.91) were revealed, elevated inflammatory markers (C-reactive protein – 4.5 mmol/L), reduced functional capacity (FRAIL – 2.0 points, SARC-F – 4.0 points), relatively preserved cognitive abilities (MMSE – 27.0 points, ASAS – 75.0 points) and vitamin D deficiency (25.50 mmol/L). The analysis showed that hypodynamia (p < 0.001), smoking (p = 0.014) and obesity (p < 0.001) were statistically significant predictors of elevated systolic BP. Moreover, elevated systolic BP was a predictor of chronic heart failure (p < 0.001), presarcopenia (p < 0.001), diabetes mellitus (p < 0.001) and age-related forgetfulness (p < 0.001).

Conclusion. The obtained data indicate the presence of pre-disease and disease states of cardiovascular nosology, metabolic disorders and reduced functional capacity in the examined patients. Further studies are needed for more detailed analysis of the revealed features and development of individualized prevention and treatment strategies.

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作者简介

I. Kochetkova

N.N. Burdenko Voronezh State Medical University, Ministry of Health of Russia

编辑信件的主要联系方式.
Email: iri4217@yandex.ru
ORCID iD: 0000-0002-7546-6679
SPIN 代码: 9933-5015

Associate Professor, Candidate of Medical Sciences

俄罗斯联邦, Voronezh

参考

  1. Порядин Г.В., Салмаси Ж.М., Мишнев О.Д. и др. Патофизиология (общая и клиническая патофизиология). Учебник для студентов учреждений высшего медицинского образования. В 2 т. Под ред. Г.В. Порядина. М.: МИА, 2022 [Poryadin G.V., Salmasy Zh.M., Mishnev O.D., et al. Pathophysiology (general and clinical pathophysiology). Textbook for students of higher medical education institutions. In 2 volumes. Edited by G.V. Poryadin. Moscow: MIA, 2022 (in Russ.)].
  2. Балабанова Ю.А., Драпкина О.М., Куценко В.А. и др. Артериальная гипертония в российской популяции в период пандемии COVID-19: гендерные различия в распространенности, лечении и его эффективности. Данные исследования ЭССЕ-РФ3. Кардиоваскулярная терапия и профилактика. 2023; 22 (8S): 3785 [Balanova Yu.A., Drapkina O.M., Kutsenko V.A. et al. Hypertension in the Russian population during the COVID-19 pandemic: sex differences in prevalence, treatment and its effectiveness. Data from the ESSE-RF3 study. Cardiovascular Therapy and Prevention. 2023; 22 (8S): 3785 (in Russ.)]. doi: 10.15829/1728-8800-2023-3785
  3. Bakris G., Chen C., Campbell A.K. et al. Association of uncontrolled blood pressure in apparent treatment-resistant hypertension with increased risk of major adverse cardiovascular events plus. J Clin Hypertens (Greenwich). 2023; 25 (8): 737–47. doi: 10.1111/jch.14701
  4. Mancia G., Kreutz R., Brunström M. et al. 2023 ESH Guidelines for the management of arterial hypertension The Task Force for the management of arterial hypertension of the European Society of Hypertension: Endorsed by the International Society of Hypertension (ISH) and the European Renal Association (ERA). J Hypertens. 2023; 41 (12): 1874–2071. doi: 10.1097/HJH.0000000000003480
  5. Yousuf F.S., Khan M.A.A., Bibi R. et al. Medication adherence in patients with uncontrolled hypertension; hypertensive crisis presenting to a hospital setting in Karachi, Pakistan. Cureus. 2023; 15 (1): e33995. doi: 10.7759/cureus.33995
  6. Mohamud M.F.Y. Clinico-epidemiological profile and risk factors of hypertensive crisis among patients attended at a tertiary care hospital in Somalia. Sci Rep. 2023; 13 (1): 447. doi: 10.1038/s41598-023-27683-4
  7. Kostev K., Yakkali B., Chaudhari S. et al. Persistence with first-line antihypertensive therapy in Germany: A retrospective cohort study with 2,801,469 patients. Int J Clin Pharmacol Ther. 2023. Online ahead of print. doi: 10.5414/CP204358
  8. Vallelonga F., Cesareo M., Menon L. et al. Hypertensive emergencies and urgencies: a preliminary report of the ongoing Italian multicentric study ERIDANO. Hypertens Res. 2023; 46 (6): 1570–81. doi: 10.1038/s41440-023-01232-y
  9. Ильницкий А.Н., Белоусов Н.И., Осипова О.А. и др. Научные исследования в области геронтологии и гериатрии в десятилетие здорового старения (2021–2030 гг.). Врач. 2021; 32 (6): 5–8 [Ilnitski A.N., Belousov N.I., Osipova O.A. et al. Researches in gerontology and geriatrics in the Decade of Healthy Aging (2021–2030). Vrach. 2021; 32 (6): 5–8 (in Russ.)]. doi: 10.29296/25877305-2021-06-01
  10. Кочеткова И.В., Трофимова Т.Г., Савельева Г.О. и др. Отношение нейтрофилов к лимфоцитам как инструмент оценки риска кардиальных осложнений у пациентов пожилого возраста с сахарным диабетом типа. Врач. 2024; 35 (12): 86–9 [Kochetkova I.V., Trofimova T.G., Savelyeva G.O. et al. Neutrophil lymphocyte coefficient as a tool for assessing the risk of cardiac complications in elderly patients with type 2 diabetes mellitus. Vrach. 2024; 35 (12): 86–9 (in Russ.)]. doi: 10.29296/25877305-2024-12-16
  11. Зацепина И.В., Кочеткова И.В., Фурсова Е.А. и др. Распространенность курения среди студентов медицинского вуза. Профилактическая медицина. 2024; 27 (6): 29–35 [Zatsepina I.V., Kochetkova I.V., Fursova E.A. et al. Smoking prevalence among students of medical university. Russian Journal of Preventive Medicine. 2024; 27 (6): 29–35 (in Russ.)]. doi: 10.17116/profmed20242706129
  12. Дедов Д. Лечение возможных кардиоваскулярных осложнений при ИБС и ХСН. Врач. 2011; 9: 66–8 [Dedov D. Treatment of possible cardiovascular complications in ischemic heart disease and chronic heart failure. Vrach. 2011; 9: 66–8 (in Russ.)].
  13. Быковский А.С., Золотых А.Е., Кочеткова И.В. и др. Изучение осведомленности о факторах риска развития хронических неинфекционных заболеваний. Молодежный инновационный вестник. 2024; 13 (S1): 399–402 [Bykovsky A.S., Zolotykh A.E., Kochetkova I.V., et al. Study of awareness of risk factors for chronic noncommunicable diseases. Youth Innovation Bulletin. 2024; 13 (S1): 399–402 (in Russ.)].
  14. Кочеткова И.В., Фурсова Е.А., Кравцова А.В. Профилактика болезней системы кровообращения и снижение сердечно-сосудистого риска на основе использования современных профессиональных стандартов. Системный анализ и управление в биомедицинских системах. 2023; 22 (2): 154–62 [Kochetkova I.V., Fursova E.A., Kravtsova A.V. Use of effective professional standards for the prevention of circulatory system diseases to reduce cardiovascular risk. System Analysis and Control in Biomedical Systems. 2023; 22 (2): 154–62 (in Russ.)]. doi: 10.36622/VSTU.2023.22.2.022
  15. Кочеткова И.В., Фурсова Е.А., Золотарева Ю.А. Общий анализ результатов социологических исследований по распространенности факторов риска развития хронических неинфекционных заболеваний у студентов ФГБОУ ВО ВГМУ Им. Н.Н. Бурденко за учебный год 2022–2023 гг. Профилактическая и клиническая медицина. 2023; 4 (89): 80–5 [Kochetkova I.V., Fursova E.A., Zolotareva Yu.A. General analysis of the results of sociological studies on the prevalenceof risk factors for the development of chronic non-infectious diseases in students of the Voronezh State Medical University named after N.N. Burdenko for the academic year (september 2022 – may 2023). Preventive and Clinical Medicine. 2023; 4 (89): 80–5 (in Russ.)]. doi: 10.47843/2074-9120_2023__4_80

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2. Fig. 1. Regression function characterizing the dependence of NT-proBNP on systolic blood pressure

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3. Fig. 2. Regression function characterizing the dependence of HbA1c on systolic blood pressure

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