Vol 27, No 9 (2016)

Method of spontaneous reports was used to identify adverse reactions associated with the replacement of the drugs with the same international nonproprietary name. The analysis of 7224 spontaneous reports in Russian data base for the period from 1 January 2015 to 30 June 2015 was done. Information about adverse reactions that occur when there was the replacement of drugs was detected in 1.9% of cases. The obtained results allowed to detect the following groups of drugs for which it was revealed the largest number of spontaneous reports of adverse reactions associated with the replacement of drugs: anti-epileptic drugs (45.9%), drugs with a narrow therapeutic index (39.2%), biologic drugs (3.7%), pancreatin (4.4%), ipratropium bromide+fenoterol (2.2%), drugs used in pediatrics (34.1%). Data that were obtained via method of spontaneous reports can be used for the primary and repeated evaluation interchangeability of medicinal drugs.

The paper shows the most important biological effects of leptin, its role in the pathogenesis of insulin resistance and type 2 diabetes mellitus, and its effect on the development of cardiovascular diseases.

The paper describes the characteristics of the structural and functional status of the heart, the status and performance of its right and left chambers in Stages I and II chronic dust-induced bronchitis, silicosis, and pneumoconiosis caused by welding aerosols. The investigators have revealed the specific features of development of hemodynamic disorders and a change in myocardial contractility in these diseases.

The paper discusses whether dyslipidemia that contributes to the occurrence and progression of atherosclerosis may be corrected with psyllium-containing medications

Incorporating different reflexotherapy options into combination therapy for metabolic disorders in obesity is shown to cause substantial clinical and metabolic changes. Pharmacopuncture with Ubiquinone compositum has yielded the most significant results.

The paper discusses the problem of diagnosing an insulin-producing tumor arising from the islets of Langerhans ß cells with manifestations of severe hypoglycemic syndrome. It provides information on the pathogenesis and clinical picture of insulinoma and methods for its diagnosis and treatment. A specific clinical example is given to trace the course of hypoglycemic syndrome in organic hyperinsulinism in a 26-year-old pregnant woman, difficulties in topical diagnosis, and the role of high-tech medical care.

The level of NT-terminal precursor of brain natriuretic peptide was ascertained to be related to the gender and age of patients with thyrotoxicosis: there was its positive correlation with the size of some heart cavities and its negative correlation with left ventricular ejection fraction.

The paper considers a pathogenic relationship of the development of articular pathology in the most common vascular diseases. It discusses current recommendations for the treatment of osteoarthritis.

A number of additional risk factors, including occupational ones, were assessed for their impact on the development of hypertensive diseases in employees of Internal Affairs bodies.

The problem of anticoagulant therapy in patients with prosthetic heart valves (PHV) is due to the type of a prosthesis, on the one hand, and to the differences in a drug response to the indirect anticoagulant warfarin, caused by external, internal, and genetic factors, on the other. So far the problems associated with the quality of controlling the level of hypocoagulation have not been solved; the use of pharmacogenetic tests relevant for warfarin susceptibility has been limited; approaches to enhancing treatment adherence in patients with PHV have not been elaborated.