卷 28, 编号 5 (2017)

The paper gives the principles of treatment of breast cancer, the volumes of its surgery, drugs, and radiotherapy, as well as a procedure for single-stage and delayed breast reconstruction.

Postcastration syndrome is a syndrome encompassing vegetovascular, neuroendocrine, and mental disorders that develop due to total oophorectomy and cause a substantial reduction in quality of life. This problem is assessed using a content analysis method.

Concomitant degenerative and dystrophic damage to the hip joints and lumbar spine may necessitate personalized correction of a treatment algorithm and placement of the components of a hip joint endoprosthesis.

The paper presents the results of investigating the role of the angiotensin converting enzyme gene in a Russian population of patients with ankylosing spondylitis.

A microdilution method was used to investigate the susceptibility of the clinical isolates of Candida albicans from vaginal discharge to the commonly used antifungal medication fluconazole. The findings were compared with the data obtained when using the disk diffusion method.

The combined treatment of 104 patients suffering from gastric cancer with peritoneal carcinomatosis encompassed surgical treatment with subsequent systemic chemotherapy cycles, as well as an implantation of a subcutaneous port and peritoneal catheter system.

The paper presents the results of investigating the detection rate and number of circulating tumor cells (CTCs) in the peripheral blood of patients with metastatic and non-metastatic colorectal cancer. The investigation revealed interesting differences between the groups. The findings prove the possibility and feasibility of using the level of CTCs as a predictor for the clinical course of a tumor process.

A difference in the biomechanics of the knee joint after arthroplasty with implants, by preserving the posterior cruciate ligament and its replacement, has been first determined using current multislice computer tomography. In the former case, the endoprosthesis has been proved to reproduce more accurately the kinematics of the healthy knee joint.

About one-third of road traffic accident victims required emergency surgery (half of them had severe mixed injury). Among the elective surgical treatments, metal osteosynthesis with angular-stable plates and blocking intramedullary metal osteosynthesis were more commonly used.

The paper describes a case of pregnancy in a patient with osteogenesis imperfecta (OI). Both Russian and foreign medicine recognizes this disorder as a contraindication to pregnancy due to the high risk of maternal and fetal complications. The paper gives data on current treatments for OI with drugs that inhibit bone resorption. It is noted that their use in women of childbearing age should be considered as an element of pregravid preparation; even in case of their discontinuation during pregnancy, they contribute to the improvement a perinatal outcome and to the intrauterine consolidation of resulting fractures. This conclusion is based on a previous clinical observation. The safety of using bisphosphonates, teriparatide, denosumab, and strontium ranelate in patients during pregnancy and, possibly, lactation is to be investigated.

The paper describes the main mechanisms of thyroid hormone actions on cholesterol metabolism and indicates the possible causes of dyslipidemia in patients with hypothyroidism.