LONG-TERM RESULTS OF ERADICATION THERAPY FOR H. pylori IN ATROPHIC GASTRITIS


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

Atrophic gastritis is an indication for compulsory eradication therapy for H. pylori, which should be considered as a means of active prophylaxis of gastric cancer. The paper discusses outcomes 18 months after successful therapy against Helicobacter pylori. A histological study indicated that regression of atrophy was not achieved and no progression of atrophy and intestinal metaplasia was seen. Gastrin 17 levels and pensinogen Vll ratio significantly increased as compared with these in the control group (receiving no eradication therapy).

About the authors

T Lapina

Email: lapinata@mail.ru

M Kon'kov

V Ivashkin

K Pyurveeva

O Sklyanskaya

A Serova

T Lapina

I.M. Sechenov Moscow Medical Academy

; I.M. Sechenov Moscow Medical Academy

M Konkov

I.M. Sechenov Moscow Medical Academy

I.M. Sechenov Moscow Medical Academy

K Purveeva

I.M. Sechenov Moscow Medical Academy

; I.M. Sechenov Moscow Medical Academy

О Sklyanskaya

I.M. Sechenov Moscow Medical Academy

; I.M. Sechenov Moscow Medical Academy

A Serova

I.M. Sechenov Moscow Medical Academy

; I.M. Sechenov Moscow Medical Academy

V Ivashkin

I.M. Sechenov Moscow Medical Academy

; I.M. Sechenov Moscow Medical Academy

References

  1. Баранская Е.К., Ивашкин ВТ. Клинический спектр предраковой патологии желудка // Рос. журн. гастроэнт., гепатол., колопроктол. - 2002; XII (3): 7-14.
  2. Кононов А.В. Цитопротекция слизистой оболочки желудка: молекулярно-клеточные механизмы // Рос. журн. гастроэнт, гепатол., колопроктол. - 2006; 3. - С. 12-16.
  3. Лапина Т.Л. Выбор схемы эрадикационной терапии при Helicobacter pylori в случае необходимости повторного лечения // Врач. - 2008; 4: 64-67.
  4. Fock К., Talley N., Moayyedi P. Asia-Pacific consensus guidelines on gastric cancer prevention // J. Gastroenterol. Hepatol. - 2008; 23 (3): 351-365.
  5. Helicobacter and Cancer Collaborative Group. Gastric cancer and Helicobacter pylori: a combined analysis of 12 case control studies nested with prospective cohorts // Gut. - 2001; 49: 347-353.
  6. Malfertheiner P., Megraud F., O'Morain С et al. Current concept in the management of Helicobacter pylori infection: the Maasticht III Consensus Report // Gut. - 2007; 56: 772-781.
  7. Storskrubb Т., Aro P., Ronkainen J. et al. Serum biomarkers provide an accurate method for diagnosis of atrophic gastritis in a general population: The Kalixanda study // Scand. J. Gastroenterol. - 2008; 43 (12): 1448-1455.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2022 Russkiy Vrach Publishing House