SUPER-RESPONSE TO CARDIAC RESYNCHRONIZATION THERAPY AND MYOCARDIAL SCINTIGRAPHY IN PATIENTS WITH HEART FAILURE


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Abstract

Cardiac resynchronization therapy (CRT) is a unique treatment for heart failure (HF) with augmented QRS; in this regard, it seems urgent to find new criteria for the prediction of a CRT super-response. While searching for these criteria, a variety of functional parameters may be put in the forefront depending on selected patient groups and used diagnostic techniques. However, the functional criteria are reversible in the vast majority of cases if HF is successfully treated. But cardiosclerosis is irreversible. Scintigraphic methods are shown to play a role in evaluating both myocardial functional parameters and cardiosclerosis. The results of the authors’ trials and clinical examples are given.

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About the authors

E. Ostroumov

V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs

Email: oenmagadan@yandex.ru
Professor

E. Kotina

Saint Petersburg State University

V. Slobodyanlk

V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs

V. Tonkoshkurova

V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs

V. Shmyrov

Saint Petersburg State University

O. Iryshkin

V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs

D. Shumakov

V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs

MD, Correspondent Member of the Russian Academy of Medical Sciences

References

  1. Национальные рекомендации ВНОК и ОССН по диагностике и лечению ХСН // Сердечн. недостат. - 2010; 11 (1): 13-4.
  2. Остроумов Е.Н., Котина Е.Д., Шмыров В.А. и др. Кардиоресинхронизирующая терапия и перфузия миокарда левого и правого желудочков // Вестн. трансплантол. и искусств. органов. - 2012; 3: 60-8.
  3. Шумаков В.И., Хубутия М.Ш., Ильинский И.М. Дилатационная кардиомиопатия / Тверь: ООО «Издательство «Триада», 2003.
  4. Appropriate Use Criteria for Implantable Cardioverter-Defibrillators and Cardiac Resynchronization Therapy // JACC. - 2013; 61 (12): 1318-68.
  5. Bleeker G., Kaandorp T., Lamb H. et al. Effect of posterolateral scar tissue on clinical and echocardiographic improvement after cardiac resynchronization therapy // Circulation. - 2006; 113: 969-76.
  6. Clements I., Christenson S., Hodge D. et al. Symptom improvement after upgrade from right ventricular apical to biventricular pacing: Role of right and left ventricular volumes assessed with single-photon emission computed tomographic equilibrium radionuclide angiocardiography // Nucl. Cardiol. - 2011; 18: 43-51.
  7. Kutyifa V., Kloppe A., Zareba W. et al. The influence of left ventricular ejection fraction on the effectiveness of cardiac resynchronization therapy: MADIT-CRT (Multicenter Automatic Defibrillator Implantation Trial With Cardiac Resynchronization Therapy) // J. Am. Coll. Cardiol. - 2013; 61 (9): 936-44.
  8. Maruyama A., Hasegawa Sh., Paul A. et al. Myocardial viability assessment with gated SPECT Tc-99m tetrofosmin wall thickening: Comparison with F-18 FDG-PET // Ann. Nucl. Med. - 2002; 16 (1): 25-32.
  9. Park M., Altman R. Orencole M. Characteristics of Responders to Cardiac Resynchronization Therapy: The Impact of Echocardiographic Left Ventricular Volume // Clin. Cardiol. - 2012; 35: 777-80.
  10. Pazhenkottil A., Buechel R., Husmann L. et al. Long-term prognostic value of left ventricular dyssynchrony assessment by phase analysis from myocardial perfusion imaging // Heart. - 2011; 97: 33-7.
  11. Reant P., Zaroui A., Donal E. et al. Identification and characterization of super-responders after cardiac resynchronization therapy // Am. J. Cardiol. - 2010; 105: 1327-35.
  12. Sutton S., Ghio S., Plappert T. et al. Cardiac resynchronization induces major structural and functional reverse remodeling in patients with New York Heart Association class I/II heart failure // Circulation. - 2009; 120: 1858-65.
  13. Tanaka H., Adelstein E., Soman P. Impact of scar burden by SPECT perfusion im-aging and echocardiographic dyssynchrony on long-term outcome after cardiac resynchronization therapy in patients with ischemic cardiomyopathy // JACC. - 2010; 55 (10A).
  14. Ypenburg C., Schalij M., Bleeker G. et al. Impact of viability and scar tissue on re-sponse to cardiac resynchronization therapy in ischemic heart failure patients // Eur. Heart J. - 2007; 28: 33-41.

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