The effect of nonsteroidal anti-inflammatory drugs on cartilage tissue
- Authors: Potupchik Т.V.1, Kapustina E.V.1,2, Klyuchnikova Е.P.1,2, Oskina V.V.1
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Affiliations:
- Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of Russia
- Krasnoyarsk Regional Clinical Hospital
- Issue: Vol 35, No 5 (2024)
- Pages: 45-48
- Section: Pharmacology
- URL: https://journals.eco-vector.com/0236-3054/article/view/633291
- DOI: https://doi.org/10.29296/25877305-2024-05-07
- ID: 633291
Cite item
Abstract
The article presents a review of studies on the effect of nonsteroidal anti-inflammatory drugs (NSAIDs) on cartilage tissue. Most studies have shown that non-selective NSAIDs, especially with prolonged use, negatively affect cartilage, accelerate cartilage destruction, inhibit prostaglandin synthesis, chondrocyte proliferation, and inhibit enzymes necessary for the synthesis of glycosaminoglycans. Cyclooxygenase-2 selective drugs have a positive effect on the condition of the cartilage matrix. However, taking into account some contradictions and insufficient information from the scientific literature of recent years, the need for further scientific research in this direction is emphasized.
Full Text
About the authors
Т. V. Potupchik
Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of Russia
Author for correspondence.
Email: potupchik_tatyana@mail.ru
Сandidate of Medical Sciences
Russian Federation, KrasnoyarskE. V. Kapustina
Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of Russia; Krasnoyarsk Regional Clinical Hospital
Email: potupchik_tatyana@mail.ru
Сandidate of Medical Sciences
Russian Federation, Krasnoyarsk; KrasnoyarskЕ. P. Klyuchnikova
Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of Russia; Krasnoyarsk Regional Clinical Hospital
Email: potupchik_tatyana@mail.ru
Russian Federation, Krasnoyarsk; Krasnoyarsk
V. V. Oskina
Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of Russia
Email: potupchik_tatyana@mail.ru
Russian Federation, Krasnoyarsk
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