Роль питательных веществ в профилактике неинфекционных заболеваний
- Авторы: Амлаев К.Р.1,2, Атоева М.А.2, Баратова М.С.2, Вохидов У.Г.2
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Учреждения:
- Ставропольский государственный медицинский университет Минздрава России
- Бухарский государственный медицинский институт им. Абу Али ибн Сино Минздрава Узбекистана
- Выпуск: Том 36, № 1 (2025)
- Страницы: 16-19
- Раздел: Лекция
- URL: https://journals.eco-vector.com/0236-3054/article/view/676817
- DOI: https://doi.org/10.29296/25877305-2025-01-03
- ID: 676817
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Аннотация
Рассматривается роль питательных веществ в профилактике неинфекционных заболеваний (НИЗ), таких как остеопороз, артериальная гипертония, деменция, нарушения зрения и другие чувствительные к дефициту определенных макро- и микронутриентов. Отмечена роль таких микронутриентов, как витамин D, витамины группы В, каротиноиды, а также лютеина, омега-3 жирных кислот в замедлении развития НИЗ с возрастом. Приведены данные о влиянии средиземноморской диеты и диеты DASH на уровень артериального давления. Указывается, что наибольший эффект от нутритивных вмешательств более выражен в популяциях с низким исходным уровнем потребления данных питательных веществ.
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Об авторах
К. Р. Амлаев
Ставропольский государственный медицинский университет Минздрава России; Бухарский государственный медицинский институт им. Абу Али ибн Сино Минздрава Узбекистана
Автор, ответственный за переписку.
Email: kum672002@mail.ru
доктор медицинских наук, профессор
Россия, Ставрополь; Бухара, УзбекистанМ. А. Атоева
Бухарский государственный медицинский институт им. Абу Али ибн Сино Минздрава Узбекистана
Email: kum672002@mail.ru
кандидат медицинских наук, доцент
Узбекистан, БухараМ. С. Баратова
Бухарский государственный медицинский институт им. Абу Али ибн Сино Минздрава Узбекистана
Email: kum672002@mail.ru
ORCID iD: 0000-0003-4790-7649
кандидат медицинских наук
Узбекистан, БухараУ. Г. Вохидов
Бухарский государственный медицинский институт им. Абу Али ибн Сино Минздрава Узбекистана
Email: kum672002@mail.ru
ORCID iD: 0000-0003-1494-0143
Узбекистан, Бухара
Список литературы
- World Health Organization (WHO) Global Health Observatory (GHO) Data, Life Expectancy. URL: https://www.who.int/data/gho/data/themes/mortality-and-global-health-estimates/ghe-life-expectancy-and-healthy-life-expectancy
- Figueira I., Fernandes A., Mladenovic Djordjevic A. et al. Interventions for age-related diseases: Shifting the paradigm. Mech Ageing Dev. 2016; 160: 69–92. doi: 10.1016/j.mad.2016.09.009
- Troesch B., Biesalski H.K., Bos R. et al. Increased Intake of Foods with High Nutrient Density Can Help to Break the Intergenerational Cycle of Malnutrition and Obesity. Nutrients. 2015; 7: 6016–37. doi: 10.3390/nu7075266
- World Health Organization (WHO). Health Statistics and Information Systems. Disease Burden and Mortality Estimates. Global Health Estimates 2016: DALYs by Age, Sex and Cause.
- Peter S., Saris W.H., Mathers J.C. et al. Nutrient Status Assessment in Individuals and Populations for Healthy Aging-Statement from an Expert Workshop. Nutrients. 2015; 7: 10491–500. doi: 10.3390/nu7125547
- De Groot L.C. Nutritional issues for older adults: Addressing degenerative ageing with long-term studies. Proc Nutr Soc. 2016; 75: 169–73. doi: 10.1017/S0029665116000033
- Siddique N., O’Donoghue M., Casey M.C. et al. Malnutrition in the elderly and its effects on bone health – A review. Clin Nutr ESPEN. 2017; 21: 31–9. doi: 10.1016/j.clnesp.2017.06.001
- Leslie W., Hankey C. Aging, Nutritional Status and Health. Healthcare (Basel). 2015; 3: 648–58. doi: 10.3390/healthcare3030648
- Kimokoti R.W., Millen B.E. Nutrition for the Prevention of Chronic Diseases. Med Clin N Am. 2016; 100: 1185–98. doi: 10.1016/j.mcna.2016.06.003
- Bruins M.J., Bird J.K., Aebischer C.P. et al. Considerations for Secondary Prevention of Nutritional Deficiencies in High-Risk Groups in High-Income Countries. Nutrients. 2018; 10: 47. doi: 10.3390/nu10010047
- Wong C.W. Vitamin B12 deficiency in the elderly: Is it worth screening? Hong Kong Med J. 2015; 21: 155–64. doi: 10.12809/hkmj144383
- Avenell A., Mak J.C., O’Connell D. Vitamin D and vitamin D analogues for preventing fractures in post-menopausal women and older men. Cochrane Database Syst Rev. 2014; 14: CD000227. doi: 10.1002/14651858.CD000227.pub4
- Beaudart C., Buckinx F., Rabenda V. et al. The effects of vitamin D on skeletal muscle strength, muscle mass, and muscle power: A systematic review and meta-analysis of randomized controlled trials. J Clin Endocrinol Metab. 2014; 99: 4336–45. doi: 10.1210/jc.2014-1742.
- Quesada-Gomez J.M., Bouillon R. Is calcifediol better than cholecalciferol for vitamin D supplementation? Osteoporos Int. 2018; 29: 1697–711. doi: 10.1007/s00198-018-4520-y
- Van Ballegooijen A.J., Pilz S., Tomaschitz A. et al. The Synergistic Interplay between Vitamins D and K for Bone and Cardiovascular Health: A Narrative Review. Int J Endocrinol. 2017; 2017: 7454376. doi: 10.1155/2017/7454376
- Moore K., Hughes C.F., Ward M., et al. Diet, nutrition and the ageing brain: Current evidence and new directions. Proc Nutr Soc. 2018; 77: 152–63. doi: 10.1017/S0029665117004177
- World Health Organization (WHO) Fact Sheets: Dementia. URL: https://www.who.int/news-room/fact-sheets/detail/dementia
- Prince M.J., Wu F., Guo Y., et al. The burden of disease in older people and implications for health policy and practice. Lancet. 2015; 385 (9967): 549–62. doi: 10.1016/S0140-6736(14)61347-7
- Jiang T., Yu J.T., Tian Y. et al. Epidemiology and etiology of Alzheimer’s disease: From genetic to non-genetic factors. Curr Alzheimer Res. 2013; 10: 852–67. doi: 10.2174/15672050113109990155
- Antal M., Péter S., Eggersdorfer M. Alzheimer’s Disease: An epidemiologic disaster from nutritional perspective. Nutr Health Food Sci. 2017; 5 (1): 1–14. doi: 10.15226/jnhfs.2017.00184
- Reynolds E.H. Folic acid, ageing, depression, and dementia. BMJ. 2002; 324 (7352): 1512–5. doi: 10.1136/bmj.324.7352.1512
- GBD 2015 DALYs and Hale Collaborators Global, regional, and national disability-adjusted life-years (DALYs) for 315 diseases and injuries and healthy life expectancy (HALE), 1990–2015: A systematic analysis for the Global Burden of Disease Study 2015. Lancet. 2016; 388 (10053): 1603–58. doi: 10.1016/S0140-6736(16)31460-X
- Chen Y., Bedell M., Zhang K. Age-related macular degeneration: Genetic and environmental factors of disease. Mol Interv. 2010; 10: 271–81. doi: 10.1124/mi.10.5.4
- Tosini G., Ferguson I., Tsubota K. Effects of blue light on the circadian system and eye physiology. Mol Vis. 2016; 22: 61–72.
- Demmig-Adams B., Adams R.B. Eye nutrition in context: Mechanisms, implementation, and future directions. Nutrients. 2013; 5: 2483–501. doi: 10.3390/nu5072483
- Bernstein P.S., Li B., Vachali P.P. et al. Lutein, zeaxanthin, and meso-zeaxanthin: The basic and clinical science underlying carotenoid-based nutritional interventions against ocular disease. Prog Retin Eye Res. 2016; 50: 34–66. doi: 10.1016/j.preteyeres.2015.10.003
- Hammond B.R., Fletcher L.M., Roos F. et al. A double-blind, placebo-controlled study on the effects of lutein and zeaxanthin on photostress recovery, glare disability, and chromatic contrast. Investig Ophthalmol Vis Sci. 2014; 55: 8583–9. doi: 10.1167/iovs.14-15573
- The Economic Benefits of Using Lutein and Zeaxanthin Food Supplements in the European Union [Internet]. Frost & Sullivan. 2017. URL: https://www.frost.com/wp-content/uploads/2017/10/HCCS_Lutein_AMD.2017.10.12.pdf
- GBD Causes of Death Collaborators Global, regional, and national age-sex specific mortality for 264 causes of death, 1980–2016: A systematic analysis for the Global Burden of Disease Study 2016. Lancet. 2017; 390 (10100): 1151–210. doi: 10.1016/S0140-6736(17)32152-9
- Leening M.J., Ferket B.S., Steyerberg E.W. et al. Sex differences in lifetime risk and first manifestation of cardiovascular disease: Prospective population based cohort study. BMJ. 2014; 349: g5992. doi: 10.1136/bmj.g5992
- Mozaffarian D. Dietary and Policy Priorities for Cardiovascular Disease, Diabetes, and Obesity: A Comprehensive Review. Circulation. 2016; 133: 187–225. doi: 10.1161/CIRCULATIONAHA.115.018585
- The Institute for Health Metrics and Evaluation (IHME) Global Burden of Disease (GBD). GBD Data Visualizations. UL: https://www.healthdata.org/research-analysis/gbd
- Hankey G.J. The Role of Nutrition in the Risk and Burden of Stroke: An Update of the Evidence. Stroke J Cereb Circ. 2017; 48: 3168–74. doi: 10.1161/STROKEAHA.117.016993
- Eckel R.H., Jakicic J.M., Ard J.D. et al. 2013 AHA/ACC guideline on lifestyle management to reduce cardiovascular risk: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation. 2014; 129 (25 Suppl 2): S76–99. doi: 10.1161/01.cir.0000437740.48606.d1
- Estruch R., Ros E., Salas-Salvado J. et al. Primary Prevention of Cardiovascular Disease with a Mediterranean Diet Supplemented with Extra-Virgin Olive Oil or Nuts. N Engl J Med. 2018; 378: e34. doi: 10.1056/NEJMoa1800389
- DiNicolantonio J.J., Bhutani J., O’Keefe J.H. The health benefits of vitamin K. Open Heart. 2015; 2: e000300. doi: 10.1136/openhrt-2015-000300
- Innes J.K., Calder P.C. The Differential Effects of Eicosapentaenoic Acid and Docosahexaenoic Acid on Cardiometabolic Risk Factors: A Systematic Review. Int J Mol Sci. 2018; 19: 532. doi: 10.3390/ijms19020532
- Thota R.N., Ferguson J.J.A., Abbott K.A. et al. Science behind the cardio-metabolic benefits of omega-3 polyunsaturated fatty acids: Biochemical effects vs. clinical outcomes. Food Funct. 2018; 9: 3576–96. doi: 10.1039/C8FO00348C
- Karalis D.G. A Review of Clinical Practice Guidelines for the Management of Hypertriglyceridemia: A Focus on High Dose Omega-3 Fatty Acids. Adv Ther. 2017; 34: 300–23. doi: 10.1007/s12325-016-0462-y
- Ye Y., Li J., Yuan Z. Effect of antioxidant vitamin supplementation on cardiovascular outcomes: A meta-analysis of randomized controlled trials. PLoS One. 2013; 8: e56803. doi: 10.1371/journal.pone.0056803
- Castro I., Waclawovsky G., Marcadenti A. Nutrition and physical activity on hypertension: Implication of current evidence and guidelines. Curr Hypertens Rev. 2015; 11: 91–9. doi: 10.2174/1573402111666150429170302
- James P.A., Oparil S., Carter B.L. et al. 2014 evidence-based guideline for the management of high blood pressure in adults: Report from the panel members appointed to the Eighth Joint National Committee (JNC 8). JAMA. 2014; 311: 507–20. doi: 10.1001/jama.2013.284427
- Miller P.E., Van Elswyk M., Alexander D.D. Long-chain omega-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid and blood pressure: A meta-analysis of randomized controlled trials. Am J Hypertens. 2014; 27: 885–96. doi: 10.1093/ajh/hpu024
- Forman J.P., Scott J.B., Ng K. et al. Effect of vitamin D supplementation on blood pressure in blacks. Hypertension. 2013; 61: 779–85. doi: 10.1161/HYPERTENSIONAHA.111.00659
- International Diabetes Federation (IDF) IDF Diabetes Atlas. 8th Ed. URL: https://diabetesatlas.org/atlas/eighth-edition/
- Samocha-Bonet D., Debs S., Greenfield J.R. Prevention and Treatment of Type 2 Diabetes: A Pathophysiological-Based Approach. Trends Endocrinol Metab. 2018; 29: 370–9. doi: 10.1016/j.tem.2018.03.014
- Chen C., Yu X., Shao S. Effects of Omega-3 Fatty Acid Supplementation on Glucose Control and Lipid Levels in Type 2 Diabetes: A Meta-Analysis. PLoS One. 2015;10: e0139565. doi: 10.1371/journal.pone.0139565
- Yoshida M., Jacques P.F., Meigs J.B. et al. Effect of vitamin K supplementation on insulin resistance in older men and women. Diabetes Care. 2008; 31: 2092–6. doi: 10.2337/dc08-1204
- Bruins M.J., Van Dael P., Eggersdorfer M. The Role of Nutrients in Reducing the Risk for Noncommunicable Diseases during Aging. Nutrients. 2019; 11 (1): 85. doi: 10.3390/nu11010085
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