The role of nutrients in the prevention of noncommunicable diseases

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Abstract

The role of nutrients in the prevention of non-communicable diseases (NCDs) is reviewed. Diseases such as osteoporosis, arterial hypertension, dementia, visual impairment and others are sensitive to a deficiency of certain macro and micronutrients, while their progression is accelerated. The role of micronutrients such as vitamin D, B vitamins, carotenoids, as well as lutein, omega-3 fatty acids in slowing the development of NCDs with age has been noted. The data on the effect of the Mediterranean diet and the DASH diet on blood pressure levels are presented. It is indicated that the greatest effect of nutritional interventions is more pronounced in populations with low baseline intake of these nutrients.

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About the authors

K. R. Amlaev

Stavropol State Medical University, Ministry of Health of Russia; Bukhara State Medical Institute named after Abu Ali ibn Sino, Ministry of Health of Uzbekistan

Author for correspondence.
Email: kum672002@mail.ru

MD Professor

Russian Federation, Stavropol; Bukhara, Uzbekistan

M. A. Atoeva

Bukhara State Medical Institute named after Abu Ali ibn Sino, Ministry of Health of Uzbekistan

Email: kum672002@mail.ru

Candidate of Medical Sciences, Associate Professor 

Uzbekistan, Bukhara

M. S. Baratova

Bukhara State Medical Institute named after Abu Ali ibn Sino, Ministry of Health of Uzbekistan

Email: kum672002@mail.ru
ORCID iD: 0000-0003-4790-7649

Candidate of Medical Sciences

Uzbekistan, Bukhara

U. G. Vohidov

Bukhara State Medical Institute named after Abu Ali ibn Sino, Ministry of Health of Uzbekistan

Email: kum672002@mail.ru
ORCID iD: 0000-0003-1494-0143
Uzbekistan, Bukhara

References

  1. World Health Organization (WHO) Global Health Observatory (GHO) Data, Life Expectancy. URL: https://www.who.int/data/gho/data/themes/mortality-and-global-health-estimates/ghe-life-expectancy-and-healthy-life-expectancy
  2. Figueira I., Fernandes A., Mladenovic Djordjevic A. et al. Interventions for age-related diseases: Shifting the paradigm. Mech Ageing Dev. 2016; 160: 69–92. doi: 10.1016/j.mad.2016.09.009
  3. Troesch B., Biesalski H.K., Bos R. et al. Increased Intake of Foods with High Nutrient Density Can Help to Break the Intergenerational Cycle of Malnutrition and Obesity. Nutrients. 2015; 7: 6016–37. doi: 10.3390/nu7075266
  4. World Health Organization (WHO). Health Statistics and Information Systems. Disease Burden and Mortality Estimates. Global Health Estimates 2016: DALYs by Age, Sex and Cause.
  5. Peter S., Saris W.H., Mathers J.C. et al. Nutrient Status Assessment in Individuals and Populations for Healthy Aging-Statement from an Expert Workshop. Nutrients. 2015; 7: 10491–500. doi: 10.3390/nu7125547
  6. De Groot L.C. Nutritional issues for older adults: Addressing degenerative ageing with long-term studies. Proc Nutr Soc. 2016; 75: 169–73. doi: 10.1017/S0029665116000033
  7. Siddique N., O’Donoghue M., Casey M.C. et al. Malnutrition in the elderly and its effects on bone health – A review. Clin Nutr ESPEN. 2017; 21: 31–9. doi: 10.1016/j.clnesp.2017.06.001
  8. Leslie W., Hankey C. Aging, Nutritional Status and Health. Healthcare (Basel). 2015; 3: 648–58. doi: 10.3390/healthcare3030648
  9. Kimokoti R.W., Millen B.E. Nutrition for the Prevention of Chronic Diseases. Med Clin N Am. 2016; 100: 1185–98. doi: 10.1016/j.mcna.2016.06.003
  10. Bruins M.J., Bird J.K., Aebischer C.P. et al. Considerations for Secondary Prevention of Nutritional Deficiencies in High-Risk Groups in High-Income Countries. Nutrients. 2018; 10: 47. doi: 10.3390/nu10010047
  11. Wong C.W. Vitamin B12 deficiency in the elderly: Is it worth screening? Hong Kong Med J. 2015; 21: 155–64. doi: 10.12809/hkmj144383
  12. Avenell A., Mak J.C., O’Connell D. Vitamin D and vitamin D analogues for preventing fractures in post-menopausal women and older men. Cochrane Database Syst Rev. 2014; 14: CD000227. doi: 10.1002/14651858.CD000227.pub4
  13. Beaudart C., Buckinx F., Rabenda V. et al. The effects of vitamin D on skeletal muscle strength, muscle mass, and muscle power: A systematic review and meta-analysis of randomized controlled trials. J Clin Endocrinol Metab. 2014; 99: 4336–45. doi: 10.1210/jc.2014-1742.
  14. Quesada-Gomez J.M., Bouillon R. Is calcifediol better than cholecalciferol for vitamin D supplementation? Osteoporos Int. 2018; 29: 1697–711. doi: 10.1007/s00198-018-4520-y
  15. Van Ballegooijen A.J., Pilz S., Tomaschitz A. et al. The Synergistic Interplay between Vitamins D and K for Bone and Cardiovascular Health: A Narrative Review. Int J Endocrinol. 2017; 2017: 7454376. doi: 10.1155/2017/7454376
  16. Moore K., Hughes C.F., Ward M., et al. Diet, nutrition and the ageing brain: Current evidence and new directions. Proc Nutr Soc. 2018; 77: 152–63. doi: 10.1017/S0029665117004177
  17. World Health Organization (WHO) Fact Sheets: Dementia. URL: https://www.who.int/news-room/fact-sheets/detail/dementia
  18. Prince M.J., Wu F., Guo Y., et al. The burden of disease in older people and implications for health policy and practice. Lancet. 2015; 385 (9967): 549–62. doi: 10.1016/S0140-6736(14)61347-7
  19. Jiang T., Yu J.T., Tian Y. et al. Epidemiology and etiology of Alzheimer’s disease: From genetic to non-genetic factors. Curr Alzheimer Res. 2013; 10: 852–67. doi: 10.2174/15672050113109990155
  20. Antal M., Péter S., Eggersdorfer M. Alzheimer’s Disease: An epidemiologic disaster from nutritional perspective. Nutr Health Food Sci. 2017; 5 (1): 1–14. doi: 10.15226/jnhfs.2017.00184
  21. Reynolds E.H. Folic acid, ageing, depression, and dementia. BMJ. 2002; 324 (7352): 1512–5. doi: 10.1136/bmj.324.7352.1512
  22. GBD 2015 DALYs and Hale Collaborators Global, regional, and national disability-adjusted life-years (DALYs) for 315 diseases and injuries and healthy life expectancy (HALE), 1990–2015: A systematic analysis for the Global Burden of Disease Study 2015. Lancet. 2016; 388 (10053): 1603–58. doi: 10.1016/S0140-6736(16)31460-X
  23. Chen Y., Bedell M., Zhang K. Age-related macular degeneration: Genetic and environmental factors of disease. Mol Interv. 2010; 10: 271–81. doi: 10.1124/mi.10.5.4
  24. Tosini G., Ferguson I., Tsubota K. Effects of blue light on the circadian system and eye physiology. Mol Vis. 2016; 22: 61–72.
  25. Demmig-Adams B., Adams R.B. Eye nutrition in context: Mechanisms, implementation, and future directions. Nutrients. 2013; 5: 2483–501. doi: 10.3390/nu5072483
  26. Bernstein P.S., Li B., Vachali P.P. et al. Lutein, zeaxanthin, and meso-zeaxanthin: The basic and clinical science underlying carotenoid-based nutritional interventions against ocular disease. Prog Retin Eye Res. 2016; 50: 34–66. doi: 10.1016/j.preteyeres.2015.10.003
  27. Hammond B.R., Fletcher L.M., Roos F. et al. A double-blind, placebo-controlled study on the effects of lutein and zeaxanthin on photostress recovery, glare disability, and chromatic contrast. Investig Ophthalmol Vis Sci. 2014; 55: 8583–9. doi: 10.1167/iovs.14-15573
  28. The Economic Benefits of Using Lutein and Zeaxanthin Food Supplements in the European Union [Internet]. Frost & Sullivan. 2017. URL: https://www.frost.com/wp-content/uploads/2017/10/HCCS_Lutein_AMD.2017.10.12.pdf
  29. GBD Causes of Death Collaborators Global, regional, and national age-sex specific mortality for 264 causes of death, 1980–2016: A systematic analysis for the Global Burden of Disease Study 2016. Lancet. 2017; 390 (10100): 1151–210. doi: 10.1016/S0140-6736(17)32152-9
  30. Leening M.J., Ferket B.S., Steyerberg E.W. et al. Sex differences in lifetime risk and first manifestation of cardiovascular disease: Prospective population based cohort study. BMJ. 2014; 349: g5992. doi: 10.1136/bmj.g5992
  31. Mozaffarian D. Dietary and Policy Priorities for Cardiovascular Disease, Diabetes, and Obesity: A Comprehensive Review. Circulation. 2016; 133: 187–225. doi: 10.1161/CIRCULATIONAHA.115.018585
  32. The Institute for Health Metrics and Evaluation (IHME) Global Burden of Disease (GBD). GBD Data Visualizations. UL: https://www.healthdata.org/research-analysis/gbd
  33. Hankey G.J. The Role of Nutrition in the Risk and Burden of Stroke: An Update of the Evidence. Stroke J Cereb Circ. 2017; 48: 3168–74. doi: 10.1161/STROKEAHA.117.016993
  34. Eckel R.H., Jakicic J.M., Ard J.D. et al. 2013 AHA/ACC guideline on lifestyle management to reduce cardiovascular risk: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation. 2014; 129 (25 Suppl 2): S76–99. doi: 10.1161/01.cir.0000437740.48606.d1
  35. Estruch R., Ros E., Salas-Salvado J. et al. Primary Prevention of Cardiovascular Disease with a Mediterranean Diet Supplemented with Extra-Virgin Olive Oil or Nuts. N Engl J Med. 2018; 378: e34. doi: 10.1056/NEJMoa1800389
  36. DiNicolantonio J.J., Bhutani J., O’Keefe J.H. The health benefits of vitamin K. Open Heart. 2015; 2: e000300. doi: 10.1136/openhrt-2015-000300
  37. Innes J.K., Calder P.C. The Differential Effects of Eicosapentaenoic Acid and Docosahexaenoic Acid on Cardiometabolic Risk Factors: A Systematic Review. Int J Mol Sci. 2018; 19: 532. doi: 10.3390/ijms19020532
  38. Thota R.N., Ferguson J.J.A., Abbott K.A. et al. Science behind the cardio-metabolic benefits of omega-3 polyunsaturated fatty acids: Biochemical effects vs. clinical outcomes. Food Funct. 2018; 9: 3576–96. doi: 10.1039/C8FO00348C
  39. Karalis D.G. A Review of Clinical Practice Guidelines for the Management of Hypertriglyceridemia: A Focus on High Dose Omega-3 Fatty Acids. Adv Ther. 2017; 34: 300–23. doi: 10.1007/s12325-016-0462-y
  40. Ye Y., Li J., Yuan Z. Effect of antioxidant vitamin supplementation on cardiovascular outcomes: A meta-analysis of randomized controlled trials. PLoS One. 2013; 8: e56803. doi: 10.1371/journal.pone.0056803
  41. Castro I., Waclawovsky G., Marcadenti A. Nutrition and physical activity on hypertension: Implication of current evidence and guidelines. Curr Hypertens Rev. 2015; 11: 91–9. doi: 10.2174/1573402111666150429170302
  42. James P.A., Oparil S., Carter B.L. et al. 2014 evidence-based guideline for the management of high blood pressure in adults: Report from the panel members appointed to the Eighth Joint National Committee (JNC 8). JAMA. 2014; 311: 507–20. doi: 10.1001/jama.2013.284427
  43. Miller P.E., Van Elswyk M., Alexander D.D. Long-chain omega-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid and blood pressure: A meta-analysis of randomized controlled trials. Am J Hypertens. 2014; 27: 885–96. doi: 10.1093/ajh/hpu024
  44. Forman J.P., Scott J.B., Ng K. et al. Effect of vitamin D supplementation on blood pressure in blacks. Hypertension. 2013; 61: 779–85. doi: 10.1161/HYPERTENSIONAHA.111.00659
  45. International Diabetes Federation (IDF) IDF Diabetes Atlas. 8th Ed. URL: https://diabetesatlas.org/atlas/eighth-edition/
  46. Samocha-Bonet D., Debs S., Greenfield J.R. Prevention and Treatment of Type 2 Diabetes: A Pathophysiological-Based Approach. Trends Endocrinol Metab. 2018; 29: 370–9. doi: 10.1016/j.tem.2018.03.014
  47. Chen C., Yu X., Shao S. Effects of Omega-3 Fatty Acid Supplementation on Glucose Control and Lipid Levels in Type 2 Diabetes: A Meta-Analysis. PLoS One. 2015;10: e0139565. doi: 10.1371/journal.pone.0139565
  48. Yoshida M., Jacques P.F., Meigs J.B. et al. Effect of vitamin K supplementation on insulin resistance in older men and women. Diabetes Care. 2008; 31: 2092–6. doi: 10.2337/dc08-1204
  49. Bruins M.J., Van Dael P., Eggersdorfer M. The Role of Nutrients in Reducing the Risk for Noncommunicable Diseases during Aging. Nutrients. 2019; 11 (1): 85. doi: 10.3390/nu11010085

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