The role of nutrients in the prevention of noncommunicable diseases
- Authors: Amlaev K.R.1,2, Atoeva M.A.2, Baratova M.S.2, Vohidov U.G.2
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Affiliations:
- Stavropol State Medical University, Ministry of Health of Russia
- Bukhara State Medical Institute named after Abu Ali ibn Sino, Ministry of Health of Uzbekistan
- Issue: Vol 36, No 1 (2025)
- Pages: 16-19
- Section: Lecture
- URL: https://journals.eco-vector.com/0236-3054/article/view/676817
- DOI: https://doi.org/10.29296/25877305-2025-01-03
- ID: 676817
Cite item
Abstract
The role of nutrients in the prevention of non-communicable diseases (NCDs) is reviewed. Diseases such as osteoporosis, arterial hypertension, dementia, visual impairment and others are sensitive to a deficiency of certain macro and micronutrients, while their progression is accelerated. The role of micronutrients such as vitamin D, B vitamins, carotenoids, as well as lutein, omega-3 fatty acids in slowing the development of NCDs with age has been noted. The data on the effect of the Mediterranean diet and the DASH diet on blood pressure levels are presented. It is indicated that the greatest effect of nutritional interventions is more pronounced in populations with low baseline intake of these nutrients.
Keywords
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About the authors
K. R. Amlaev
Stavropol State Medical University, Ministry of Health of Russia; Bukhara State Medical Institute named after Abu Ali ibn Sino, Ministry of Health of Uzbekistan
Author for correspondence.
Email: kum672002@mail.ru
MD Professor
Russian Federation, Stavropol; Bukhara, UzbekistanM. A. Atoeva
Bukhara State Medical Institute named after Abu Ali ibn Sino, Ministry of Health of Uzbekistan
Email: kum672002@mail.ru
Candidate of Medical Sciences, Associate Professor
Uzbekistan, BukharaM. S. Baratova
Bukhara State Medical Institute named after Abu Ali ibn Sino, Ministry of Health of Uzbekistan
Email: kum672002@mail.ru
ORCID iD: 0000-0003-4790-7649
Candidate of Medical Sciences
Uzbekistan, BukharaU. G. Vohidov
Bukhara State Medical Institute named after Abu Ali ibn Sino, Ministry of Health of Uzbekistan
Email: kum672002@mail.ru
ORCID iD: 0000-0003-1494-0143
Uzbekistan, Bukhara
References
- World Health Organization (WHO) Global Health Observatory (GHO) Data, Life Expectancy. URL: https://www.who.int/data/gho/data/themes/mortality-and-global-health-estimates/ghe-life-expectancy-and-healthy-life-expectancy
- Figueira I., Fernandes A., Mladenovic Djordjevic A. et al. Interventions for age-related diseases: Shifting the paradigm. Mech Ageing Dev. 2016; 160: 69–92. doi: 10.1016/j.mad.2016.09.009
- Troesch B., Biesalski H.K., Bos R. et al. Increased Intake of Foods with High Nutrient Density Can Help to Break the Intergenerational Cycle of Malnutrition and Obesity. Nutrients. 2015; 7: 6016–37. doi: 10.3390/nu7075266
- World Health Organization (WHO). Health Statistics and Information Systems. Disease Burden and Mortality Estimates. Global Health Estimates 2016: DALYs by Age, Sex and Cause.
- Peter S., Saris W.H., Mathers J.C. et al. Nutrient Status Assessment in Individuals and Populations for Healthy Aging-Statement from an Expert Workshop. Nutrients. 2015; 7: 10491–500. doi: 10.3390/nu7125547
- De Groot L.C. Nutritional issues for older adults: Addressing degenerative ageing with long-term studies. Proc Nutr Soc. 2016; 75: 169–73. doi: 10.1017/S0029665116000033
- Siddique N., O’Donoghue M., Casey M.C. et al. Malnutrition in the elderly and its effects on bone health – A review. Clin Nutr ESPEN. 2017; 21: 31–9. doi: 10.1016/j.clnesp.2017.06.001
- Leslie W., Hankey C. Aging, Nutritional Status and Health. Healthcare (Basel). 2015; 3: 648–58. doi: 10.3390/healthcare3030648
- Kimokoti R.W., Millen B.E. Nutrition for the Prevention of Chronic Diseases. Med Clin N Am. 2016; 100: 1185–98. doi: 10.1016/j.mcna.2016.06.003
- Bruins M.J., Bird J.K., Aebischer C.P. et al. Considerations for Secondary Prevention of Nutritional Deficiencies in High-Risk Groups in High-Income Countries. Nutrients. 2018; 10: 47. doi: 10.3390/nu10010047
- Wong C.W. Vitamin B12 deficiency in the elderly: Is it worth screening? Hong Kong Med J. 2015; 21: 155–64. doi: 10.12809/hkmj144383
- Avenell A., Mak J.C., O’Connell D. Vitamin D and vitamin D analogues for preventing fractures in post-menopausal women and older men. Cochrane Database Syst Rev. 2014; 14: CD000227. doi: 10.1002/14651858.CD000227.pub4
- Beaudart C., Buckinx F., Rabenda V. et al. The effects of vitamin D on skeletal muscle strength, muscle mass, and muscle power: A systematic review and meta-analysis of randomized controlled trials. J Clin Endocrinol Metab. 2014; 99: 4336–45. doi: 10.1210/jc.2014-1742.
- Quesada-Gomez J.M., Bouillon R. Is calcifediol better than cholecalciferol for vitamin D supplementation? Osteoporos Int. 2018; 29: 1697–711. doi: 10.1007/s00198-018-4520-y
- Van Ballegooijen A.J., Pilz S., Tomaschitz A. et al. The Synergistic Interplay between Vitamins D and K for Bone and Cardiovascular Health: A Narrative Review. Int J Endocrinol. 2017; 2017: 7454376. doi: 10.1155/2017/7454376
- Moore K., Hughes C.F., Ward M., et al. Diet, nutrition and the ageing brain: Current evidence and new directions. Proc Nutr Soc. 2018; 77: 152–63. doi: 10.1017/S0029665117004177
- World Health Organization (WHO) Fact Sheets: Dementia. URL: https://www.who.int/news-room/fact-sheets/detail/dementia
- Prince M.J., Wu F., Guo Y., et al. The burden of disease in older people and implications for health policy and practice. Lancet. 2015; 385 (9967): 549–62. doi: 10.1016/S0140-6736(14)61347-7
- Jiang T., Yu J.T., Tian Y. et al. Epidemiology and etiology of Alzheimer’s disease: From genetic to non-genetic factors. Curr Alzheimer Res. 2013; 10: 852–67. doi: 10.2174/15672050113109990155
- Antal M., Péter S., Eggersdorfer M. Alzheimer’s Disease: An epidemiologic disaster from nutritional perspective. Nutr Health Food Sci. 2017; 5 (1): 1–14. doi: 10.15226/jnhfs.2017.00184
- Reynolds E.H. Folic acid, ageing, depression, and dementia. BMJ. 2002; 324 (7352): 1512–5. doi: 10.1136/bmj.324.7352.1512
- GBD 2015 DALYs and Hale Collaborators Global, regional, and national disability-adjusted life-years (DALYs) for 315 diseases and injuries and healthy life expectancy (HALE), 1990–2015: A systematic analysis for the Global Burden of Disease Study 2015. Lancet. 2016; 388 (10053): 1603–58. doi: 10.1016/S0140-6736(16)31460-X
- Chen Y., Bedell M., Zhang K. Age-related macular degeneration: Genetic and environmental factors of disease. Mol Interv. 2010; 10: 271–81. doi: 10.1124/mi.10.5.4
- Tosini G., Ferguson I., Tsubota K. Effects of blue light on the circadian system and eye physiology. Mol Vis. 2016; 22: 61–72.
- Demmig-Adams B., Adams R.B. Eye nutrition in context: Mechanisms, implementation, and future directions. Nutrients. 2013; 5: 2483–501. doi: 10.3390/nu5072483
- Bernstein P.S., Li B., Vachali P.P. et al. Lutein, zeaxanthin, and meso-zeaxanthin: The basic and clinical science underlying carotenoid-based nutritional interventions against ocular disease. Prog Retin Eye Res. 2016; 50: 34–66. doi: 10.1016/j.preteyeres.2015.10.003
- Hammond B.R., Fletcher L.M., Roos F. et al. A double-blind, placebo-controlled study on the effects of lutein and zeaxanthin on photostress recovery, glare disability, and chromatic contrast. Investig Ophthalmol Vis Sci. 2014; 55: 8583–9. doi: 10.1167/iovs.14-15573
- The Economic Benefits of Using Lutein and Zeaxanthin Food Supplements in the European Union [Internet]. Frost & Sullivan. 2017. URL: https://www.frost.com/wp-content/uploads/2017/10/HCCS_Lutein_AMD.2017.10.12.pdf
- GBD Causes of Death Collaborators Global, regional, and national age-sex specific mortality for 264 causes of death, 1980–2016: A systematic analysis for the Global Burden of Disease Study 2016. Lancet. 2017; 390 (10100): 1151–210. doi: 10.1016/S0140-6736(17)32152-9
- Leening M.J., Ferket B.S., Steyerberg E.W. et al. Sex differences in lifetime risk and first manifestation of cardiovascular disease: Prospective population based cohort study. BMJ. 2014; 349: g5992. doi: 10.1136/bmj.g5992
- Mozaffarian D. Dietary and Policy Priorities for Cardiovascular Disease, Diabetes, and Obesity: A Comprehensive Review. Circulation. 2016; 133: 187–225. doi: 10.1161/CIRCULATIONAHA.115.018585
- The Institute for Health Metrics and Evaluation (IHME) Global Burden of Disease (GBD). GBD Data Visualizations. UL: https://www.healthdata.org/research-analysis/gbd
- Hankey G.J. The Role of Nutrition in the Risk and Burden of Stroke: An Update of the Evidence. Stroke J Cereb Circ. 2017; 48: 3168–74. doi: 10.1161/STROKEAHA.117.016993
- Eckel R.H., Jakicic J.M., Ard J.D. et al. 2013 AHA/ACC guideline on lifestyle management to reduce cardiovascular risk: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation. 2014; 129 (25 Suppl 2): S76–99. doi: 10.1161/01.cir.0000437740.48606.d1
- Estruch R., Ros E., Salas-Salvado J. et al. Primary Prevention of Cardiovascular Disease with a Mediterranean Diet Supplemented with Extra-Virgin Olive Oil or Nuts. N Engl J Med. 2018; 378: e34. doi: 10.1056/NEJMoa1800389
- DiNicolantonio J.J., Bhutani J., O’Keefe J.H. The health benefits of vitamin K. Open Heart. 2015; 2: e000300. doi: 10.1136/openhrt-2015-000300
- Innes J.K., Calder P.C. The Differential Effects of Eicosapentaenoic Acid and Docosahexaenoic Acid on Cardiometabolic Risk Factors: A Systematic Review. Int J Mol Sci. 2018; 19: 532. doi: 10.3390/ijms19020532
- Thota R.N., Ferguson J.J.A., Abbott K.A. et al. Science behind the cardio-metabolic benefits of omega-3 polyunsaturated fatty acids: Biochemical effects vs. clinical outcomes. Food Funct. 2018; 9: 3576–96. doi: 10.1039/C8FO00348C
- Karalis D.G. A Review of Clinical Practice Guidelines for the Management of Hypertriglyceridemia: A Focus on High Dose Omega-3 Fatty Acids. Adv Ther. 2017; 34: 300–23. doi: 10.1007/s12325-016-0462-y
- Ye Y., Li J., Yuan Z. Effect of antioxidant vitamin supplementation on cardiovascular outcomes: A meta-analysis of randomized controlled trials. PLoS One. 2013; 8: e56803. doi: 10.1371/journal.pone.0056803
- Castro I., Waclawovsky G., Marcadenti A. Nutrition and physical activity on hypertension: Implication of current evidence and guidelines. Curr Hypertens Rev. 2015; 11: 91–9. doi: 10.2174/1573402111666150429170302
- James P.A., Oparil S., Carter B.L. et al. 2014 evidence-based guideline for the management of high blood pressure in adults: Report from the panel members appointed to the Eighth Joint National Committee (JNC 8). JAMA. 2014; 311: 507–20. doi: 10.1001/jama.2013.284427
- Miller P.E., Van Elswyk M., Alexander D.D. Long-chain omega-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid and blood pressure: A meta-analysis of randomized controlled trials. Am J Hypertens. 2014; 27: 885–96. doi: 10.1093/ajh/hpu024
- Forman J.P., Scott J.B., Ng K. et al. Effect of vitamin D supplementation on blood pressure in blacks. Hypertension. 2013; 61: 779–85. doi: 10.1161/HYPERTENSIONAHA.111.00659
- International Diabetes Federation (IDF) IDF Diabetes Atlas. 8th Ed. URL: https://diabetesatlas.org/atlas/eighth-edition/
- Samocha-Bonet D., Debs S., Greenfield J.R. Prevention and Treatment of Type 2 Diabetes: A Pathophysiological-Based Approach. Trends Endocrinol Metab. 2018; 29: 370–9. doi: 10.1016/j.tem.2018.03.014
- Chen C., Yu X., Shao S. Effects of Omega-3 Fatty Acid Supplementation on Glucose Control and Lipid Levels in Type 2 Diabetes: A Meta-Analysis. PLoS One. 2015;10: e0139565. doi: 10.1371/journal.pone.0139565
- Yoshida M., Jacques P.F., Meigs J.B. et al. Effect of vitamin K supplementation on insulin resistance in older men and women. Diabetes Care. 2008; 31: 2092–6. doi: 10.2337/dc08-1204
- Bruins M.J., Van Dael P., Eggersdorfer M. The Role of Nutrients in Reducing the Risk for Noncommunicable Diseases during Aging. Nutrients. 2019; 11 (1): 85. doi: 10.3390/nu11010085
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