BRAIN-DERIVED NEUROTROPHIC FACTOR AS AN INDICATOR OF CENTRAL NERVOUS SYSTEM DISEASES
- 作者: Zykova Y.V1, Evert L.S2, Potupchik T.V3
-
隶属关系:
- OOO «Medicine of Computer Technologies» Medical and Diagnostic Clinic
- Federal Research Center “Krasnoyarsk Research Center, Siberian Branch, Russian Academy of Sciences
- Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of Russia
- 期: 卷 32, 编号 4 (2021)
- 页面: 5-9
- 栏目: Articles
- URL: https://journals.eco-vector.com/0236-3054/article/view/114402
- DOI: https://doi.org/10.29296/25877305-2021-04-01
- ID: 114402
如何引用文章
详细
The paper reviews the literature on the involvement of brain-derived neurotrophic factor (BDNF) in the pathogenesis of many diseases of the central nervous system. It presents data of the studies showing a correlation between BDNF deficiency in the brain and blood tissues and neurodegenerative diseases, such as AlzheimePs, Huntington’s, Parkinson’s diseases, hypoxia, headaches and migraines, and psychoemotional disorders. It is shown that BDNF can serve as a marker for predicting the course of diseases and evaluating the efficiency of treatment.
全文:
作者简介
Yu. Zykova
OOO «Medicine of Computer Technologies» Medical and Diagnostic ClinicKrasnoyarsk
L. Evert
Federal Research Center “Krasnoyarsk Research Center, Siberian Branch, Russian Academy of SciencesMD, Research Institute for Medical Problems of the North Krasnoyarsk
T. Potupchik
Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of Russia
Email: potupchik_tatyana@mail.ru
Candidate of Medical Sciences Krasnoyarsk
参考
- Астраханова Т.А., Уразов М.Д., Усенко А.В. и др. BDNF-опосредованная регуляция функционального состояния митохондрий клеток головного мозга в условиях гипоксии. Современные технологии в медицине. 2018; 10 (3): 88-94
- Белоусова Н.П., Громова О.А., Пепеляев Е.Г. и др. Взаимосвязь когнитивных нарушений и уровня BDNF у лиц молодого возраста. Медицина в Кузбассе. 2017; 16 (4): 39-43
- Рудницкая Е.А., Колосова Н.Г., Стефанова Н.А. Нейротрофическое обеспечение головного мозга в онтогенезе и при развитии нейродегенеративных заболеваний. Вестник Московского Университета. Серия 16: Биология. 2016; 4: 72-82
- Тян К.В., Калинский П.П., Ракитова А.В. Тревожно-депрессивная симптоматика и уровень нейротрофического фактора головного мозга у пациентов с головной болью напряжения. Пермский медицинский журнал. 2017; 34 (6): 34-9
- Эверт Л.С., Потупчик Т.В., Реушева С.В. и др. Уровень мозгового нейротрофического фактора BDNF у подростков с дисплазией соединительной ткани и различными психосоматическими синдромами. Современные проблемы науки и образования. 2018; 5: 61
- Anderson M.A., Burda J.E., Ren Y. et al. Astrocyte scar formation aids central nervous system axon regeneration. Nature. 2016; 532 (7598): 195-200. doi: 10.1038/nature17623
- Badrlou E., Ghafouri-Fard S., Omrani M.D. et al. Expression of BDNF-Associated lncRNAs in Treatment-Resistant Schizophrenia Patients. Mol Neurosci. 2021; 5. Online ahead of print. doi: 10.1007/s12031-020-01772-9
- Bawari S., Sandro T., Archana A. et al. Targeting BDNF signaling by natural products: novel synaptic repair therapeutics for neurodegeneration and behavior disorders. Pharmacol Res. 2019; 148: 104458. doi: 10.1016/j.phrs.2019.104458.
- Beeri M.S., Sonnen J. Brain BDNF expression as a biomarker for cognitive reserve against Alzheimer disease progression. Neurology. 2016; 86 (8): 702-3. doi: 10.1212/WNL.0000000000002389
- Blanco-Suârez E., Caldwell A.L., Allen N.J. Role of astrocyte-synapse interactions in CNS disorders. J Physiol. 2017; 595 (6): 1903-16. DOI: 10.1113/ JP270988
- Blandini F., Rinaldi L., Tassorelli C. et al. Peripheral levels of BDNF and NGF in primary headaches. Cephalalgia. 2006; 26 (2): 136-42. doi: 10.1111/j.1468-2982.2005.01006.x
- Boschen K.E., Klintsova A.Y. Neurotrophins in the brain: interaction with alcohol exposure during development. Vitamins and hormones. 2017; 104: 197-242. doi: 10.1016/bs.vh.2016.10.008
- Budni J., Bellettini-Santos T., Mina F. et al. The involvement of BDNF, NGF and GDNF in aging and Alzheimer's disease. Aging Dis. 2015; 6 (5): 331-41. doi: 10.14336/AD.2015.0825
- Chan A., Yan J., Csurhes P. et al. Circulating brain derived neurotrophic factor (BDNF) and frequency of BDNF positive T cells in peripheral blood in human ischemic stroke: effect on outcome. J Neuroimmunol. 2015; 286: 42-7. doi: 10.1016/j.jneuroim.2015.06.013
- De Almeida Claudino F.C., Gonçalves L., Felipe Barreto Schuch F.B. et al. The Effects of Individual Psychotherapy in BDNF Levels of Patients With Mental Disorders: A Systematic Review. Front Psychiatry. 2020; 11: 445. DOI: 10.3389/ fpsyt.2020.00445
- Devi L., Ohno M. TrkB reduction exacerbates Alzheimer's disease-like signaling aberrations and memory deficits without affecting beta-amyloidosis in 5XFAD mice. TranslPsychiatry. 2015; 5 (5): e562. doi: 10.1038/tp.2015.55
- Eyileten C., Kaplon-Cieslicka A., Mirowska-Guzel D. et al. Antidiabetic effect of brain-derived neurotrophic factor and its association with inflammation in type 2 diabetes mellitus. J Diabetes Res. 2017; 2017: 1-14. doi: 10.1155/2017/2823671
- Ferreira R.N., de Miranda A.S., Rocha N.P. et al. Neurotrophic factors in Parkinson’s disease: what have we learned from pre-clinical and clinical studies? Curr Med Chem. 2018; 25: 3682-702. doi: 10.2174/0929867325666180313101536
- Fischer M., Wille G., Klien S. et al. Brain-derived neurotrophic factor in primary headaches. J Headache Pain. 2012; 13 (6): 469-75. doi: 10.1007/s10194-012-0454-5
- Gandolfi M., Smania N., Vella A. et al. Assessed and Emerging Biomarkers in Stroke and Training-Mediated Stroke Recovery: State of the Art. Neural Plast. 2017; 2017: 1389475. doi: 10.1155/2017/1389475
- Geisel O., Banas R., Schneider M. et al. Serum levels of brain-derived neurotrophic factor in patients with internet use disorder. Psychiatry Res. 2013; 209 (3): 525-8. doi: 10.1016/j.psychres.2012.12.020.
- Gorshkov K., Aguisanda F., Thorne N. et al. Astrocytes as targets for drug discovery. Drug Discov Today. 2018; 23 (3): 673-80. DOI: 10.1016/j. drudis.2018.01.011
- Hing B., Sathyaputri L., Potash J.B. A comprehensive review of genetic and epigenetic mechanisms that regulate BDNF expression and function with relevance to major depressive disorder. Am J Med Genet B Neuropsychiatr Genet. 2018; 177 (2): 143-67. doi: 10.1002/ajmg.b.32616
- Hwang K.S., Lazaris A.S., Eastman J.A. et al. Alzheimer’s Disease Neuroimaging Initiative. Plasma BDNF levels associate with Pittsburgh compound B binding in the brain. Alzheimers Dement. 2015; 1: 187-93. DOI: 10.1016/j. dadm.2015.01.005
- Johnson D., Lanahan A., Buck C.R. et al. Expression and structure of the human NGF receptor. Cell. 1986; 47 (4): 545-54. doi: 10.1016/0092-8674(86)90619-7
- Kaminari A., Giannakas N., Tzinia A. et al. Overexpression of matrix metalloproteinase-9 (MMP-9) rescues insulin-mediated impairment in the 5XFAD model of Alzheimer’s disease. Sci Rep. 2017; 7 (1): 683. doi: 10.1038/s41598-017-00794-5
- Kaplan D.R., Hempstead B.L., Martin-Zanca D. et al. The trk protooncogene product: a signal transducing receptor for nerve growth factor. Science. 1991; 252 (5005): 554-8. doi: 10.1126/science.1850549
- Kim H.S., Jeon I., Noh J.E. et al. Intracerebral Transplantation of BDNF-overexpressing Human Neural Stem Cells (HB1.F3.BDNF) Promotes Migration, Differentiation and Functional Recovery in a Rodent Model of Huntington’s Disease. Exp Neurobiol. 2020; 29 (2): 130-7. doi: 10.5607/en20011
- Kopec B.M., Zhao L., Rosa-Molinar E. et al. Non-invasive Brain Delivery and Efficacy of BDNF in APP/PS1 Transgenic Mice as a Model of Alzheimer’s Disease. Med Res Arch. 2020; 8 (2): 2043. doi: 10.18103/mra.v8i2.2043
- Lesniak A., Poznanski P., Religa P. et al. Loss of Brain-Derived Neurotrophic Factor (BDNF) Resulting From Congenital- Or Mild Traumatic Brain Injury-Induced Blood-Brain Barrier Disruption Correlates With Depressive-Like Behaviour. Neuroscience. 2021; 17: S0306-4522(21)00020-8. DOI: 10.1016/j. neuroscience.2021.01.013
- Lu B., Nagappan G., Lu Y. BDNF and synaptic plasticity, cognitive function, and dysfunction. Handb Exp Pharmacol. 2014; 220: 223-50. doi: 10.1007/978-3-642-45106-5_9
- Naegelin Y., Saeuberli K., Schaedelin S. et al. Levels of brain-derived neurotrophic factor in patients with multiple sclerosis. Ann Clin Transl Neurol. 2020; 7 (11): 2251-61. doi: 10.1002/acn3.51215
- Nguyen K.Q., Rymar V.V., Sadikot A.F. Impaired TrkB Signaling Underlies Reduced BDNF-Mediated Trophic Support of Striatal Neurons in the R6/2 Mouse Model of Huntington’s Disease. Front Cell Neurosci. 2016; 10: 37. DOI: 10.3389/ fncel.2016.00037
- Miranda M., Morici J.F., Zanoni M.B. et al. Brain-derived neurotrophic factor: a key molecule for memory in the healthy and the pathological brain. Front Cell Neurosci. 2019; 13: 363. doi: 10.3389/fncel.2019.00363
- Paillard T., Rolland Y., de Souto Barreto P. Protective Effects of Physical Exercise in Alzheimer’s Disease and Parkinson’s Disease: A Narrative Review. J Clin Neurol. 2015; 11 (3): 212-9. doi: 10.3988/jcn.2015.11.3.212
- Palasz E., Wysocka A., Gasiorowska A. et al. BDNF as a Promising Therapeutic Agent in Parkinson’s Disease. Int J Mol Sci. 2020; 21 (3): 1170. doi: 10.3390/ijms21031170
- Palma-Âlvarez R.F., Ros-Cucurull E., Amaro-Hosey K. et al. Peripheral levels of BDNF and opiate-use disorder: literature review and update. Rev Neurosci. 2017; 28 (5): 499-508.
- Pins B., Cifuentes-Diaz C., Farah A.T. et al. Conditional BDNF Delivery from Astrocytes Rescues Memory Deficits, Spine Density, and Synaptic Properties in the 5xFAD Mouse Model of Alzheimer Disease. J Neurosci. 2019; 39 (13): 2441-58. doi: 10.1523/JNEUROSCI.2121-18.2019
- Rios M. Neurotrophins and the regulation of energy balance and body weight. Handb Exp Pharmacol. 2014; 220: 283-307. doi: 10.1007/978-3-642-45106-5_11
- Satomura E., Baba H., Nakano Y. et al. Correlations between brain-derived neurotrophic factor and clinical symptoms in medicated patients with major depression. J Affect Disord. 2011; 135 (1-3): 332-5. DOI: 10.1016/j. jad.2011.06.041
- Sheeler C., Rosa J.G., Borgenheimer E. et al. Post-symptomatic Delivery of Brain-Derived Neurotrophic Factor (BDNF) Ameliorates Spinocerebellar Ataxia Type 1 (SCA1) Pathogenesis. Cerebellum. 2021; Online ahead of print. DOI: 10.1007/ s12311-020-01226-3
- Song J.H, Yu J.T., Tan L. Brain-derived neurotrophic factor in Alzheimer’s disease: risk, mechanisms, and therapy. Mol Neurobiol. 2015; 52: 1477-93. doi: 10.1007/s12035-014-8958-4
- Sordyl J., Kopyta I., Sarecka-Hujar B. et al. Lipid levels and selected biomarkers of vascular changes in children with idiopathic headaches - a preliminary report. Arch Med Sci. 2019; 15 (1): 120-5. DOI: 10.5114/ aoms.2018.73983
- Tanure M.T., Gomez R.S., Hurtado R.C. et al. Increased serum levels of brain-derived neurotropic factor during migraine attacks: a pilot study. J Headache Pain. 2010; 11 (5): 427-30. doi: 10.1007/s10194-010-0233-0
- Toda T., Gage F.H. Review: adult neurogenesis contributes to hippocampal plasticity. Cell Tissue Res. 2017; 373: 693-709. doi: 10.1007/s00441 -017-2735-4
- Ventriglia M., Zanardini R., Bonomini C. et al. Serum brain-derived neurotrophic factor levels in different neurological diseases. BiomedRes Int. 2013; 2013: 901082. doi: 10.1155/2013/901082
- Weinstein G., Preis S.R., Beiser A.S. et al. Clinical and environmental correlates of serum BDNF: a descriptive study with plausible implications for AD research. Curr Alzheimer Res. 2017; 14: 722-30. doi: 10.2174/156720501466617 0203094520
- Zaman Emon M.P., Das R., Nishuty N.L.et al. Reduced serum BDNF levels are associated with the increased risk for developing MDD: a case-control study with or without antidepressant therapy. Res Notes. 2021; 13 (1): 83. DOI: 10.1186/ s13104-020-04952-3
- Zhang X., Xue Y., Li J. et al. The involvement of ADAR1 in antidepressant action by regulating BDNF via miR-432. Behav Brain Res. 2021; 402: 113087. doi: 10.1016/j.bbr.2020.113087
- Zhang Z., Liu X., Schroeder J.P. et al. 7,8-Dihydroxyflavone prevents synaptic loss and memory deficits in a mouse model of Alzheimer’s disease. Neuropsychopharmacology. 2014; 39 (3): 638-50. doi: 10.1038/npp.2013.243