VITAMIN U (S-METHYLMETHIONINE): METABOLIC EFFECTS AND CLINICAL EFFICACY
- 作者: Astapovskiy A.A1, Zhukova O.V1, Drozdov V.N1, Shikh E.V1
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隶属关系:
- I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia
- 期: 卷 33, 编号 10 (2022)
- 页面: 51-55
- 栏目: Articles
- URL: https://journals.eco-vector.com/0236-3054/article/view/114706
- DOI: https://doi.org/10.29296/25877305-2022-10-10
- ID: 114706
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详细
Key points. S-methylmethionine, better known as vitamin U, is a metabolic substrate that affects many metabolic processes in the human body. It was first discovered in the 50s of the last centuries in cabbage juice. Since then, a large number of pre-clinical and clinical studies have been produced that have demonstrated the safety and effectiveness of vitamin U in various diseases. gastroprotective, hypolipidemic, antioxidant and organoprotective properties of vitamin U. In this review, more attention is paid to the gastroprotective properties of S-methylmethionine. Nevertheless, data are presented demonstrating its hypolipidemic, antioxidant and organoprotective properties, which allow the possibility of expanding the scope of its application in the future. Conclusion. The accumulated data on the effectiveness of vitamin U allow us to consider it as an adjunct to the main therapy of gastritis and ulcers in order to increase efficiency, as well as a means to prevent exacerbations.
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作者简介
A. Astapovskiy
I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia
Email: vndrozdov@yandex.ru
俄罗斯联邦,
O. Zhukova
I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia
Email: vndrozdov@yandex.ru
Candidate of Medical Sciences
俄罗斯联邦,V. Drozdov
I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia
Email: vndrozdov@yandex.ru
Professor, MD
俄罗斯联邦,E. Shikh
I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia
编辑信件的主要联系方式.
Email: vndrozdov@yandex.ru
Professor, MD
俄罗斯联邦,参考
- Kim K., Kim J., Kim M. et al. Effect of Enhancers on in vitro and in vivo Skin Permeation and Deposition of S-Methyl-L-Methionine. Biomol Ther (Seoul). 2017; 25 (4): 434-40. doi: 10.4062/biomolther.2016.254
- Cheney G. Anti-Peptic Ulcer Dietary Factor (Vitamin “U”) in the Treatment of Peptic Ulcer. J Am Diet Assoc. 1950; 26 (9): 668-72. doi: 10.1016/s0002-8223(21)30396-0
- Patel A., Prajapati N. Review on biochemical importance of vitamin-U. J Chem Pharm Res. 2012; 4 (1): 209-15.
- Нормы физиологической потребности (МР 2.3.1.2432-08). URL: https://docs.cntd.ru/document/1200076084
- Kim G. Determination of Vitamin U in Food Plants. Food Science and Technology Research. 2003; 9 (4): 316-9. doi: 10.3136/fstr.9.316
- Nakamura N., Uzawa H. Hypolipidemic effect of L-form S-methylmethionine sulfonium chloride in man. Arzneimittelforschung. 1981; 31 (4): 725-9.
- Seri K., Amemiya K., Sugimoto H. et al. Effects of S-methylmethionine (vitamin U) on experimental nephrotic hyperlipidemia. Arzneimittelforschung. 1979; 29 (10): 1517-20.
- Lee N., Park K., Min H. et al. Inhibitory Effect of Vitamin U (S-Methylmethionine Sulfonium Chloride) on Differentiation in 3T3-L1 Pre-adipocyte Cell Lines. Ann Dermatol. 2012; 24 (1): 39. doi: 10.5021/ad.2012.24.1.39
- Gessler N.N., Kharchenko L.I., Pavlovskaya T.E. et al. Antiradiation effects of S-methylmethionine (vitamin U). Applied Biochemistry and Microbiology. 1996; 32 (6): 599-601.
- Tunali S., Kahraman S., Yanardag R. Vitamin U, a novel free radical scavenger, prevents lens injury in rats administered with valproic acid. Hum Exp Toxicol. 2014; 34 (9): 904-10. doi: 10.1177/0960327114561665
- Sokmen B., Tunali S., Yanardag R. Effects of vitamin U (S-methyl methionine sulphonium chloride) on valproic acid induced liver injury in rats. Food Chem Toxicol. 2012; 50 (10): 3562-6. doi: 10.1016/j.fct.2012.07.056
- Kim W., Yang Y., Min H. et al. Accelerated Wound Healing by S-Methylmethionine Sulfonium: Evidence of Dermal Fibroblast Activation via the ERK1/2 Pathway. Pharmacology. 2010; 85 (2): 68-76. doi: 10.1159/000276495
- Kim W., Seo H., Kim W. et al. The Photoprotective Effect of S-Methylmethionine Sulfonium in Skin.Int J Mol Sci. 2015; 16 (8): 17088-100. doi: 10.3390/ijms160817088
- Liu H., Lu P., Guo Y. et al. An integrative genomic analysis identifies as a diet-dependent genetic factor protecting against acetaminophen-induced liver toxicity. Genome Res. 2009; 20 (1): 28-35. doi: 10.1101/gr.097212.109
- Watanabe T., Ohara S., Ichikawa T. et al. Mechanisms for cytoprotection by vitamin U from ethanol-induced gastric mucosal damage in rats. Dig Dis Sci. 1996; 41 (1): 49-54. doi: 10.1007/bf02208583
- Ichikawa T., Ito Y., Saegusa Y. et al. Effects of combination treatment with famotidine and methylmethionine sulfonium chloride on the mucus barrier of rat gastric mucosa. J Gastroenterol Hepatol. 2009; 24 (3): 488-92. doi: 10.1111/j.1440-1746.2008.05667.x
- Suzue R. Bulletin of the Institute for Chemical Research, Kyoto University. 1967; 45: 201.
- Hikichi T., Sato M., Watanabe K. et al. Peptic Ulcers in Fukushima Prefecture Related to the Great East Japan Earthquake, Tsunami and Nuclear Accident.Intern Med. 2018; 57 (7): 915-21. doi: 10.2169/internalmedicine.9252-17
- Salim A. Administration of Sulfhydryls to Stimulate the Healing of Ischemia-Induced Acute Gastric Mucosal Injury in the Rat. J Pharm Sci. 1991; 80 (6): 539-41. DOI: 10.1002/ jps.2600800607
- Peterson W., Ciociola A., Sykes D. et al. Ranitidine bismuth citrate plus clarithromycin is effective for healing duodenal ulcers, eradicating H. pylori and reducing ulcer recurrence. RBC H. pylori Study Group [see comments]. Aliment Pharmacol Ther. 1996; 10 (3): 251-61. doi: 10.1111/j.0953-0673.1996.00251.x
- Дроздов В.Н., Ших Е.В., Стародубцева А.К. и др. Хронический гастрит и идиопа-тическая пептическая язва, перспективы применения S-метилметионина (витамин U) в комплексной терапии. Трудный пациент. 2018; 6 (16): 12-8.
- Диетология. Руководство. 5-е изд. Под ред. А.Ю. Барановского. СПб: Питер, 2017. 1104 с.
- Niv Y. Membrane-bound mucins and mucin terminal glycans expression in idiopathic or Helicobacter pylori, NSAID associated peptic ulcers. World J Gastroenterol. 2014; 20 (40): 14913. doi: 10.3748/wjg.v20.i40.14913
- Мансуров Х.Х., Пинхасов И.И. Результаты клинического испытания витамина U при язвенной болезни и хроническом гастрите. Витамин U (S-метилметионин). Природа, свойства, применение. М.: Наука, 1973; с. 53-60.
- Франк Ю.П., Коржукова П.И. Применение витамина U у больных язвенной болезнью двенадцатиперстной кишки и хроническим гастритом. Язвенная болезнь двенадцатиперстной кишки (патогенез, диагностика, лечение). М., 1981; с. 110-6.
- Нестерова А.П., Тайц Н.С., Гурвич М.М. и др. Значение витамина U в комплексном лечении гиперацидного гастрита и дуоденита. Институт питания АМН СССР, 1973; с. 108-12.
- Трусов В.В., Орешков Т.М. Опыт лечения больных хроническим гастритом витамином U «Витамин U (S-метилметионин) (природа, свойства, применение)». М.: Наука, 1973; с. 112-9.
- Анисимов В.Е. Эффективность применения отечественного препарата витамина U приязвенной болезни желудка и двенадцатиперстной кишки. Витамин U (S-Метилметионин). Природа, свойства, применение. М.: Наука, 1973; с. 64-71.
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