EVALUATION OF THE EFFICIENCY OF COMBINED PHARMACOTHERAPY


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详细

The efficiency of combined pharmacotherapies was evaluated in rheumatic patients, by comparing the quantitative parameters of prediction of expected and potential drug interactions. The specific risk factors of potential drug interactions were assessed from the number of drugs that affected common pharmacodynamics and pharmacokinetic targets. The quantitative parameters of the nonspecific risk factors characterizing the total number of concurrently used drugs, their doses, and therapeutic range were obtained.

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作者简介

O. Astapova

Research Center for Examination of Medical Products

R. Syubaev

Research Center for Examination of Medical Products

Email: subaev@expmed.ru

M. Zhuravleva

Research Center for Examination of Medical Products

D. Sychev

Research Center for Examination of Medical Products

G. Engalycheva

Research Center for Examination of Medical Products

A. Vasilyev

Research Center for Examination of Medical Products

参考

  1. Margo L., Moretti U., Leone R. Epidemiology and characteristics of adverse drug reactions caused by drug-drug interactions // Exp. Opin. Drug Safety. - 2012; 1: 83-94.
  2. Mirosevic Skvrce N., Macolic Sarinic V., Muealo I. et al. Adverse drug reactions caused by drug-drug interactions reported to Croatian Agency for Medicinal Products and Medical Devices; a retrospective observational study // Croat. Med. J. - 2011; 52 (5): 604-14.
  3. Oertle M. Frequency and nature of drug-drug interactions in a Swiss primary and secondary acute care hospital // Swiss. Med. Wkly. - 2012; 142: 13 522.
  4. Гуськова Т.А., Сюбаев Р.Д. Влияние комбинаторного фактора на достоверность теоретического прогноза эффектов многокомпонентного токсикологического взаимодействия // Токсикол. вестн. - 2003; 4: 2-11.
  5. Сюбаев Р.Д., Енгалычева Г.Н. Доклиническая оценка безопасности лекарственного взаимодействия // Лекарственные средства. - 2011; 3 (4): 39-44.
  6. Енгалычева Г.Н., Сюбаев Р.Д., Меркулов В.А. и др. Анализ результатов доклинических исследований безопасности лекарственных средств // Ведомости НЦЭСМП. - 2013; 2: 9-11.
  7. Государственный реестр лекарственных средств - URL: http://grls. rosminzdrav.ru/ (дата обращения апрель 2013 г.).
  8. Wishart D., Knox C., Guo A. et al. DrugBank: a knowledgebase for drugs, drug actions and drug targets База данных DrugBank (www.drugbank.ca) // Nucleic. Acids Res. - 2008; 36 (Database issue): 901-6. PMID: 18048412 (дата обращения май 2013 г.).

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