Diagnosis of stress and sympathetic activation by parameters of skin conductance: the current state of the method, fields of application and prospects in medicine
- 作者: Kuzyukova A.A.1, Zagainova A.Y.1, Odarushenko O.I.1, Pechova Y.G.1, Marchenkova L.A.1, Fesyun A.D.1
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隶属关系:
- National Medical Research Center for Rehabilitation and Balneology, Ministry of Health of Russia
- 期: 卷 35, 编号 7 (2024)
- 页面: 76-83
- 栏目: From Practice
- URL: https://journals.eco-vector.com/0236-3054/article/view/634657
- DOI: https://doi.org/10.29296/25877305-2024-07-13
- ID: 634657
如何引用文章
详细
The article provides a justification for the importance of objectification of stressful conditions in medical institutions. It is noted that in comparison with other biosignals, skin conductance as a form of electrodermal activity (EDA), is a simpler, more accessible, and suitable method for routine practice to assess the state of the sympathetic nervous system, the activation of which plays a leading role in stress. In accordance with the stated goal of studying modern techniques that use EDA signals to understand their capabilities in the diagnosis and correction of stress and other conditions in medicine, the article presents data on literary sources indicating a steadily growing interest in the ED ED method at the present time; describes the physiological mechanisms of formation of EDA signals and ways to measure them, types of electrodes and places of their superposition, types of signal processing, dependence of EDA indicators on environmental factors and individual characteristics; areas and prospects of application in medicine, indicating the high accuracy of the method for determining stress conditions, features of emotional disorders and pain, the possibility of monitoring the condition of patients with epilepsy, severe somatic diseases and in the postoperative period. In conclusion, a description of modern domestic studies using a Stress monitoring System based on EDA registration is given to monitor stroke patients undergoing rehabilitation and the effectiveness of anesthesia after cesarean section, confirming that taking into account EDA indicators can significantly optimize the diagnosis of stress conditions, emotional pathology and pain.
作者简介
A. Kuzyukova
National Medical Research Center for Rehabilitation and Balneology, Ministry of Health of Russia
编辑信件的主要联系方式.
Email: kuzyukovaaa@nmicrk.ru
ORCID iD: 0000-0002-9275-6491
Candidate of Medical Sciences
俄罗斯联邦, MoscowA. Zagainova
National Medical Research Center for Rehabilitation and Balneology, Ministry of Health of Russia
Email: kuzyukovaaa@nmicrk.ru
ORCID iD: 0000-0003-3987-3901
Candidate of Biological Sciences
俄罗斯联邦, MoscowO. Odarushenko
National Medical Research Center for Rehabilitation and Balneology, Ministry of Health of Russia
Email: kuzyukovaaa@nmicrk.ru
ORCID iD: 0000-0002-0416-3558
Candidate of Psychological Sciences
俄罗斯联邦, MoscowYa. Pechova
National Medical Research Center for Rehabilitation and Balneology, Ministry of Health of Russia
Email: kuzyukovaaa@nmicrk.ru
ORCID iD: 0000-0002-2754-1021
Candidate of Medical Sciences
俄罗斯联邦, MoscowL. Marchenkova
National Medical Research Center for Rehabilitation and Balneology, Ministry of Health of Russia
Email: kuzyukovaaa@nmicrk.ru
ORCID iD: 0000-0003-1886-124X
MD
俄罗斯联邦, MoscowA. Fesyun
National Medical Research Center for Rehabilitation and Balneology, Ministry of Health of Russia
Email: kuzyukovaaa@nmicrk.ru
ORCID iD: 0000-0003-3097-8889
Associate Professor, MD
俄罗斯联邦, Moscow参考
- Эбзеева Е.Ю., Полякова О.А. Стресс и стресс-индуцированные расстройства. Медицинский совет. 2022; 16 (2): 127–33 [Ebzeeva E.Y., Polyakova O.A. Stress and stress-induced disorders. Medical Council. 2022;(2):127-133 (in Russ.)]. doi: 10.21518/2079-701X-2022-16-2-127-133
- Есин Р.Г., Есин О.Р., Хакимова А.Р. Стресс-индуцированные расстройства. Журнал неврологии и психиатрии им. С.С. Корсакова. 2020; 120 (5): 131–7 [Esin R.G., Esin O.R., Khakimova A.R. Stress-induced disorders. S.S. Korsakov Journal of Neurology and Psychiatry. 2020; 120 (5): 131–7 (in Russ.)]. doi: 10.17116/jnevro2020120051131
- Posada-Quintero H.F., Chon K.H. Innovations in Electrodermal Activity Data Collection and Signal Processing: A Systematic Review. Sensors (Basel). 2020; 20 (2): 479. doi: 10.3390/s20020479
- Еханин С.Г. Кожно-гальваническая реакция: датчики, приборы, исследования: Методические указания к лабораторному занятию по дисциплине. Биомедицинские приборы и датчики [Электронный ресурс]. Томск: ТУСУР, 2022; 25 с. [Ekhanin S.G. Skin-galvanic reaction: sensors, devices, researches: Methodical instructions to the laboratory session on the discipline. Biomedical devices and sensors [Electronic resource]. Tomsk: TUSUR, 2022; 25 p. (in Russ.)]. URL: https://edu.tusur.ru/publications/9947
- Tronstad C., Amini M., Bach D.R. et al.. Current trends and opportunities in the methodology of electrodermal activity measurement. Physiol Meas. 2022; 43 (2). doi: 10.1088/1361-6579/ac5007
- Subramanian S., Purdon P.L., Barbieri R. et al. Elementary integrate-and-fire process underlies pulse amplitudes in Electrodermal activity. PLoS Comput Biol. 2021; 17 (7): e1009099. doi: 10.1371/journal.pcbi.1009099
- Bhatkar V., Picard R., Staahl C. Combining Electrodermal Activity With the Peak-Pain Time to Quantify Three Temporal Regions of Pain Experience. Front Pain Res (Lausanne). 2022; 3: 764128. doi: 10.3389/fpain.2022.764128
- Sánchez-Reolid R., López de la Rosa F., Sánchez-Reolid D. et al. Machine Learning Techniques for Arousal Classification from Electrodermal Activity: A Systematic Review. Sensors (Basel). 2022; 22 (22): 8886. doi: 10.3390/s22228886
- McNaboe R.Q., Hossain M.B., Kong Y. et al. Validation of Spectral Indices of Electrodermal Activity with a Wearable Device. Annu Int Conf IEEE Eng Med Biol Soc. 2021; 2021: 6991–4. doi: 10.1109/EMBC46164.2021.9630005
- Barman S.M., Kenney M.J. Methods of analysis and physiological relevance of rhythms in sympathetic nerve discharge. Clin Exp Pharmacol Physiol. 2007; 34: 350–5. doi: 10.1111/j.1440-1681.2007.04586.x
- Barman S.M., Yate В.J. Deciphering the Neural Control of Sympathetic Nerve Activity: Status Report and Directions for Future Research. Front Neurosci. 2017; 11: 730. doi: 10.3389/fnins.2017.00730
- Qasim M.S., Bari D.S., Martinsen Ø.G. Influence of ambient temperature on tonic and phasic electrodermal activity components. Physiol Meas. 2022; 43 (6). doi: 10.1088/1361-6579/ac72f4
- Bari D.S., Aldosky H.Y.Y., Tronstad C. et al. Influence of Relative Humidity on Electrodermal Levels and Responses. Skin Pharmacol Physiol. 2018; 31 (6): 298–307. doi: 10.1159/000492275
- Aldosky H.Y. Impact of obesity and gender differences on electrodermal activities. Gen Physiol Biophys. 2019; 38 (6): 513–8. doi: 10.4149/gpb_2019036
- Bari D.S., Yacoob Aldosky H.Y. et al. Simultaneous measurement of electrodermal activity components correlated with age-related differences. J Biol Phys. 2020; 46 (2): 177–88. doi: 10.1007/s10867-020-09547-4
- Chong L.S., Lin B., Gordis E. Racial differences in sympathetic nervous system indicators: Implications and challenges for research. Biol Psychol. 2023; 177: 108496. doi: 10.1016/j.biopsycho.2023.108496
- Hickey B.A., Chalmers T., Newton P. et al. Smart Devices and Wearable Technologies to Detect and Monitor Mental Health Conditions and Stress: A Systematic Review. Sensors (Basel). 2021; 21 (10): 3461. doi: 10.3390/s21103461
- Rahma O.N., Putra A.P., Rahmatillah A. et al. Electrodermal Activity for Measuring Cognitive and Emotional Stress Level. J Med Signals Sens. 2022; 12 (2): 155–62. doi: 10.4103/jmss.JMSS_78_20
- Almadhor A., Sampedro G.A., Abisado M. et al. Wrist-Based Electrodermal Activity Monitoring for Stress Detection Using Federated Learning. Sensors (Basel). 2023; 23 (8): 3984. doi: 10.3390/s23083984
- Klimek A., Mannheim I., Schouten G. et al. Wearables measuring electrodermal activity to assess perceived stress in care: a scoping review. Acta Neuropsychiatr. 2023; 1–11. doi: 10.1017/neu.2023.19
- Posada-Quintero H.F., Florian J.P., Orjuela-Cañón A.D. et al.. Electrodermal Activity Is Sensitive to Cognitive Stress under Water. Front Physiol. 2018; 8: 1128. doi: 10.3389/fphys.2017.01128
- Wincewicz K., Nasierowski T. Electrodermal activity and suicide risk assessment in patients with affective disorders. Psychiatr Pol. 2020; 54 (6): 1137–47. doi: 10.12740/PP/110144
- Пудиков И.В. Диагностика риска суицидального поведения по динамическим показателям электродермальной реакции. Военно-медицинский журнал. 2023; 344 (10): 41–6 [Pudikov I.V. Diagnosis of the risk of suicidal behavior by dynamic indicators of the electrodermal reaction. Voenno-medicinskij žurnal. 2023; 344 (10): 41–6 (in Russ.)]. doi: 10.52424/00269050_2023_344_10_41
- Carli V., Hadlaczky G., Petros N.G. et al. European Multi-Center Clinical Study of Electrodermal Reactivity and Suicide Risk Among Patients With Depression. Front Psychiatry. 2022; 12: 765128. doi: 10.3389/fpsyt.2021.765128
- Anmella G., Mas A., Sanabra M. et al. Electrodermal activity in bipolar disorder: Differences between mood episodes and clinical remission using a wearable device in a real-world clinical setting. J Affect Disord. 2024; 345: 43–50. doi: 10.1016/j.jad.2023.10.125
- Schiltz H.K., Fenning R.M., Erath S.A. et al. Electrodermal Activity Moderates Sleep-Behavior Associations in Children with Autism Spectrum Disorder. Res Child Adolesc Psychopathol. 2022; 50 (6): 823–35. doi: 10.1007/s10802-022-00900-w
- Visnovcova Z., Ferencova N., Grendar M. et al. Electrodermal activity spectral and nonlinear analysis - potential biomarkers for sympathetic dysregulation in autism. Gen Physiol Biophys. 2022; 41 (2): 123–31. doi: 10.4149/gpb_2022011
- Schach S., Rings T., Bregulla M. et al. Electrodermal Activity Biofeedback Alters Evolving Functional Brain Networks in People With Epilepsy, but in a Non-specific Manner. Front Neurosci. 2022; 16: 828283. doi: 10.3389/fnins.2022.828283
- Horinouchi T., Sakurai K., Munekata N. et al. Decreased electrodermal activity in patients with epilepsy. Epilepsy Behav. 2019; 100 (Pt A): 106517. doi: 10.1016/j.yebeh.2019.106517
- Vieluf S., Amengual-Gual M., Zhang B. et al. Twenty-four-hour patterns in electrodermal activity recordings of patients with and without epileptic seizures. Epilepsia. 2021; 62 (4): 960–72. doi: 10.1111/epi.16843
- Casanovas Ortega M., Bruno E., Richardson M.P. Electrodermal activity response during seizures: A systematic review and meta-analysis. Epilepsy Behav. 2022; 134: 108864. doi: 10.1016/j.yebeh.2022.108864
- Sebastião R., Bento A., Brás S. Analysis of Physiological Responses during Pain Induction. Sensors (Basel). 2022; 22 (23): 9276. doi: 10.3390/s22239276
- Thiam P., Bellmann P., Kestler H.A. et al. Exploring Deep Physiological Models for Nociceptive Pain Recognition. Sensors (Basel). 2019; 19 (20): 4503. doi: 10.3390/s19204503
- Kong Y., Posada-Quintero H.F., Chon K.H. Sensitive Physiological Indices of Pain Based on Differential Characteristics of Electrodermal Activity. IEEE Trans Biomed Eng. 2021; 68 (10): 3122–30. doi: 10.1109/TBME.2021.3065218
- Johansen A.O., Mølgaard J., Rasmussen S.S. et al. Deviations in continuously monitored electrodermal activity before severe clinical complications: a clinical prospective observational explorative cohort study. J Clin Monit Comput. 2023; 37 (6): 1573–84. doi: 10.1007/s10877-023-01030-4
- Kuderava Z., Kozar M., Visnovcova Z. et al. Sympathetic nervous system activity and pain-related response indexed by electrodermal activity during the earliest postnatal life in healthy term neonates. Physiol Res. 2023; 72 (3): 393–401. doi: 10.33549/physiolres.935061
- Упрямова Е.Ю., Шифман Е.М., Дегтярев П.А. и др. Оценка качества послеоперационного обезболивания после кесарева сечения по данным системы мониторинга стрессовых состояний: проспективное одноцентровое рандомизированное клиническое сравнительное исследование. Регионарная анестезия и лечение острой боли. 2023; 17 (4): 267–77 [Upryamova E.Y., Shifman E.M., Degtyarev P.A. et al. Postoperative pain relief quality after cesarean section using a stress monitor (Neon FSC system): prospective single-center randomized clinical comparative study. Regional Anesthesia and Acute Pain Management. 2023; 17 (4): 267–77 (in Russ.)]. doi: 10.17816/RA608168
- Кузюкова А.А., Рачин А.П., Колышенков В.А. Мониторинг электродермальной активности для определения стрессовых состояний, эмоциональных нарушений и эффективности проводимых реабилитационных мероприятий по их коррекции у пациентов с инсультами: пилотное исследование. Вестник Восстановительной медицины. 2022; 21 (6): 19–29 [Kuzyukova A.A., Rachin A.P., Kolyshenkov V.A. Electrodermal Activity Monitoring for Stroke Patients Stress States, Еmotional Disturbances, Rehabilitation Measures Effectiveness Specification: a Pilot Study. Bulletin of Rehabilitation Medicine. 2022; 21 (6): 19–29 (in Russ.)]. doi: 10.38025/2078-1962-2022-21-6-19-29
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