Regulation of glutathione levels: the role of vitamins, micronutrients, nutrients and nutritional strategies

E. V. Shrayner; Шрайнер Е. В.; V. I. Bystrova; Быстрова В. И.; E. A. Pokushalov; Покушалов Е. А.; A. D. Romanova; Романова А. Д.; D. S. Markin; Маркин Д. С.; D. A. Kudlay; Кудлай Д. А.

doi:10.29296/25877305-2025-10-03

Regulation of glutathione levels: the role of vitamins, micronutrients, nutrients and nutritional strategies

作者: Shrayner E.V.¹^,2^,3^,4, Bystrova V.I.¹^,2, Pokushalov E.A.³^,4, Romanova A.D.⁵, Markin D.S.¹, Kudlay D.A.¹^,6^,7
隶属关系:
1. Novosibirsk National Research State University
2. Institute of Chemical Biology and Fundamental Medicine of Siberian Branch of the Russian Academy of Sciences
3. Center for New Medical Technologies
4. "Soloways" laboratory
5. Murmansk Arctic University
6. I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)
7. M.V. Lomonosov Moscow State University
期: 卷 36, 编号 10 (2025)
页面: 15-20
栏目: Lecture
URL: https://journals.eco-vector.com/0236-3054/article/view/696291
DOI: https://doi.org/10.29296/25877305-2025-10-03
ID: 696291

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详细

Glutathione (GSH) is a central component of the body's antioxidant system involved in protection against oxidative stress, detoxification, regulation of immune response and metabolic stability. GSH deficiency is associated with a multitude of pathologic conditions including neurodegenerative and cancer diseases, HIV, inflammatory and metabolic disorders. This review considers nutrient strategies for increasing glutathione levels: vitamins (C, E, B6), selenium, magnesium, omega-3, alpha-lipoic acid, amino acids (glutamine, glycine, cysteine, serine, taurine), and protein sources. Data on the efficacy of various forms of GSH delivery – oral, liposomal, sublingual, and intravenous - are highlighted. The influence of genetic polymorphisms and dietary patterns (Mediterranean diet, DASH, vegetarianism) on glutathione metabolism is reviewed. The presented data emphasize the importance of an integrated approach to the maintenance of redox homeostasis and the need for a personalized strategy of glutathione status correction taking into account nutrient saturation, genetics and clinical background of the patient.

关键词

glutathione, glutathione deficiency, regulation of glutathione level, vitamins, trace elements, omega-3, alpha-lipoic acid, amino acids, nutrients, nutritional strategies

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作者简介

E. Shrayner

Novosibirsk National Research State University; Institute of Chemical Biology and Fundamental Medicine of Siberian Branch of the Russian Academy of Sciences; Center for New Medical Technologies; "Soloways" laboratory

编辑信件的主要联系方式.
Email: sch704@icloud.com
ORCID iD: 0000-0003-3606-4068
SPIN 代码: 1089-6080

Candidate of Medical Sciences

俄罗斯联邦, Novosibirsk; Novosibirsk; Novosibirsk; Novosibirsk

V. Bystrova

Novosibirsk National Research State University; Institute of Chemical Biology and Fundamental Medicine of Siberian Branch of the Russian Academy of Sciences

Email: sch704@icloud.com
ORCID iD: 0000-0003-3522-5384
SPIN 代码: 4479-6770
俄罗斯联邦, Novosibirsk; Novosibirsk

E. Pokushalov

Center for New Medical Technologies; "Soloways" laboratory

Email: sch704@icloud.com
ORCID iD: 0000-0002-9494-4234
SPIN 代码: 1032-1810

Professor, Corresponding Member of the Russian Academy of Sciences, MD

俄罗斯联邦, Novosibirsk; Novosibirsk

Corresponding Member of the Russian Academy of Sciences, MD

俄罗斯联邦, Novosibirsk; Moscow; Moscow

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