Endometrial hyperplasia: prospects for development of the problem


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Abstract

The paper considers the present views of the classification, risk factors, pathogenetic mechanisms responsible for endometrial hyperplasia (EH), its association with the development of uterine mucosal cancer. The efficiency of different hormonal therapy options and regimens is comparatively evaluated in different forms of EH and information on the frequency of its recurrences is given. Whether it is expedient to revise and objectify a classification system, to search for molecular genetic predictors of EH and to develop objective methods for predicting its development and the occurrence of relapses is discussed. The necessity of working out a short- and long-term management programs is justified for patients, by keeping in mind their age, a form of EH, a wish to be pregnant.

About the authors

Galina Evgen'evna Chernukha

Email: inter@pregnancy.ru

G Ye Chernukha

V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies

V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies

References

  1. Чиссов В. И., Старинский В. В., Петрова Г. В. Злокачественные новообразования в России в 2006 г. (Заболеваемость и смертность). - М., 2008.
  2. Шигорева Т. В. Клинико-морфологические аспекты внутриматочного воздействия левоноргестрела при гипеплазии эндометрия: Автореф. дис. ? канд. мед. наук. - М., 2008.
  3. Agorastos T., Vaitsi V., Paschopoulos M.et al. // Maturitas. - 2004. - Vol. 48, N 2. - P. 125-132.
  4. Barakat R. R. // Oncology (Williston Park). - 1995. - Vol. 9, N 2. - P. 129-134.
  5. Bergeron C., Nogales F. F., Masseroli M. et al. // Am. J. Surg. Pathol. - 1999. - Vol. 23. - P. 1102-1108.
  6. Boruban M. C., Altundag K., Kilic G. S., Blankstein J. // Eur. J. Cancer Prev. - 2008. - Vol. 17, N 2. - P. 133-138.
  7. Bulun S. E., Simpson E. R. // Adv. Exp. Med. Biol. - 2008. - Vol. 630. - P. 112-132.
  8. Clark T. J., Neelakantan D., Gupta J. K. // Eur. J. Obstetr. Gynecol. Reprod. Biol. - 2006. - Vol. 125, N 2. - P. 259-264.
  9. Doherty J. A., Cushing-Haugen K. L., Saltzman B. S. et al. // Am. J. Obstetr. Gynecol. - 2007. - Vol. 197, N 2. - P. 139-147.
  10. Epplein M., Reed S. D., Voigt L. F. et al. // Am. J. Epidemiol. - 2008. - Vol. 168, N 6. - P. 563-570.
  11. Grimbizis G., Tsalikis T., Tzioufa V. et al. // Hum. Reprod. - 1999. - Vol. 14, N 2. - P. 479-484.
  12. Grьndker C., Gьnthert A. R., Emons G. // Adv. Exp. Med. Biol. - 2008. - Vol. 630. - P. 166-188.
  13. Haimovich S., Checa M. A., Mancebo G. et al. // Menopause. - 2008. - Vol. 15, N 5. - P. 1002-1004.
  14. Horn L. C., Schnurrbusch U., Bilek K. et al. // Int. J. Gynecol. Cancer. - 2004. - Vol. 14, N 2. - P. 348-353.
  15. Jemal A., Siegel R., Ward E. et al. // Cancer J. Clin. - 2007. - Vol. 57. - P. 43-66.
  16. Kendall B. S., Ronnett B. M., Isacson C. et al. // Am. J. Surg. Pathol. - 1998. - Vol. 22. - P. 1012-1019.
  17. Kurman R. J., Kaminski P. F., Norris H. J. // Cancer (Philad.). - 1985. - Vol. 56. - P. 403-412.
  18. Matias-Guiu X., Catasus L., Bussaglia E. et al. // Hum. Pathol. - 2001. - Vol. 32, N 6. - P. 569-577.
  19. Mourits M. J., De Vries E. G., Willemse P. H. et al. // Obstetr. and Gynecol. - 2001. - Vol. 97, N 5, Pt 2. - P. 855-866.
  20. Mutter G. L., Zaino R. J., Baak J. P. A. et al. // Int. J. Gynecol. Pathol. - 2007. - Vol. 26, N 2. - P. 103-114.
  21. Orbo A., Arnes M., Hancke C. et al. // Gynecol. Oncol. - 2008. - Vol. 111, N 1. - P. 68-73.
  22. Radowicki S., Skцrzewska K. // Ginekol. Pol. - 2003. - Vol. 74, N 9. - P. 836-839.
  23. Sherman M. E., Ronnett B. M., Ioffe O. B. et al. // Int. J. Gynecol. Pathol. - 2008. - Vol. 27, N 3. - P. 318-325.
  24. Takai N., Ueda T., Nishida M. et al. // Curr. Cancer Drug Targets. - 2004. - Vol. 4, N 6. - P. 511-520.
  25. Trimble C. L., Kauderer J., Zaino R. et al. // Cancer. - 2006. - Vol. 106, N 4. - P. 812-819.
  26. Ushijima K., Yahata H., Yoshikawa H. et al. // J. Clin. Oncol. - 2007. - Vol. 25, N 19. - P. 2798-2803.
  27. Varma R., Soneja H., Bhatia K. et al. // Eur. J. Obstetr. Gynecol. Reprod. Biol. - 2008. - Vol. 139, N 2. - P. 169-175.
  28. Vereide A. B., Kaino T., Sager G. et al. // Gynecol. Oncol. - 2006. - Vol. 101, N 2. - P. 214-223.
  29. Xie X., Lu W. G., Ye D. F. et al. // Gynecol. Oncol. - 2002. - Vol. 84, N 1. - P. 135-139.
  30. Zaino R. J., Kauderer J., Trimble C. L. et al. // Cancer. - 2006. - Vol. 106, N 4. - P. 804-811.

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