Poor predictors of the HLA system in married couples with habitual early miscarriages
- Authors: Petrosyan LA1, Faizullin LZ2, Karnaukhov VN2
-
Affiliations:
- I. M. Sechenov Moscow Medical Academy
- Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Sciences, Moscow
- Issue: No 5 (2009)
- Pages: 12-15
- Section: Articles
- URL: https://journals.eco-vector.com/0300-9092/article/view/246112
- ID: 246112
Cite item
Full Text
Abstract
The study was performed in 64 married couples with habitual pregnancy loss in the first trimester, who had compatibility of 3 HLA antigens or more, the rate of which in the structure of miscarriage is 24.6%. The poor predictors of early reproductive loss may be a homozygous genotype in women for the DQA1 locus, genotype 0301/0301 for the DQB1 locus, genotype 0501/0501, DQA1 and/or DQB1 0201 allele in men. Both the specific features of a HLA genotype in each husband/wife and compatibility for these antigens in the married couple were ascertained to affect the course of pregnancy in the early periods.
Keywords
About the authors
L A Petrosyan
I. M. Sechenov Moscow Medical AcademyI. M. Sechenov Moscow Medical Academy
L Z Faizullin
Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Sciences, Moscow
Email: ncagp@bk.ru
Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Sciences, Moscow
V N Karnaukhov
Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Sciences, MoscowAcademician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Sciences, Moscow
References
- Дзенис И. Г. Современные пути диагностики и профилактики наследственной недостаточности 21-гидроксилазы: Автореф. дис. ... д-ра мед. наук. - М., 1996.
- Салбиева Н. Г. Особенности кариотипа и феномена HLA супружеских пар с привычным невынашиванием беременности: Автореф. дис. ... канд. мед. наук. - М., 2002.
- Серова Л. Д., Манишкина Т. В. и др. Иммунологический HLA-статус у женщин с привычным невынашиванием беременности неясного генеза: Метод. рекомендации. - М., 1998.
- Сидельникова В. М. Привычная потеря беременности. - М., 2002.
- Шахгюлян Я. Л. Совместимость по системе HLA при привычном невынашивании беременности, диагностика и терапия: Автореф. дис. ... канд. мед. наук. - М., 2006.
- Aplin J. D., Haigh T., Lacey H. et al. // J. Reprod. Fertil. - 2000. - Vol. 55, Suppl. - P. 57-64.
- Beer A. E., Kwak J. Reproductive Medicine Program // Finch University of Health Science. - Chicago, 1999.
- Beer A. E., Kwak J. Reproductive Medicine Program // Finch University of Health Science. - Chicago, 2000.
- Bulmer J. N. // Immunology of Reproduction. - Oxforf, 1995. - P. 313-321.
- Clover L. M., Sargent I. L., Townsend A. et al. // Eur. J. Immunol. - 1995. - Vol. 25, N 2. - P. 543-553.
- Coulam C. B., Kryza L. W., Bustillo M. // Hum. Reprod. - 1994. - Vol. 9, N 12. - P. 2265-2269.
- Fraser E. J., Gremes D. A., Schultz K. F. // Obstet. and Gynecol. - 1993. - Vol. 82, N 5. - P. 854-859.
- Hameed A., Ahmed A. R. // Dermatol. Clin. - 1993. - Vol. 11, N 3. - P. 391-398.
- Kravitt L., Kilby A., Albertini R. et al. // Hepatology. - 1997. - Vol. 7. - P. 1305-1310.
- Kwak J. Y., Beaman K. D., Gilman-Sachs A. // Am. J. Reprod. Immunol. - 1997. - Vol. 37. - P. 354.
- Ober C., Hyslop T., Elias S. et al. // Hum. Reprod. - 1998. - Vol. 13. - P. 33-38.
Supplementary files
