The significance of uterine pathology and the specific features of pregestational preparation of women with habitual early pregnancy loss


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Abstract

The study was conducted in 125 women with habitual pregnancy loss (HPL) in the first trimester and in 71 women without a history of obstetric and somatic diseases. HPL was caused by uterine pathology. The patients underwent endometrial ultrasonography and Doppler study for examination of uterine hemodynamics. The composition of an endometrial lymphocytic subpopulation was also determined. Uterine hemodynamic disorders were revealed in 56% of the women with the adequate endometrial status in the intended use period. A concurrence of endometrial immaturity and hemodynamic disorders was observed in 44%. The analysis of endometrial lymphocytic subpopulation established increases in the count of CD56 cells up to 70% and apoptotic markers (CD95) up to 55%. The use of vasoactive drugs in combination with estrogen-gestagen agents and the correction of immunological disorders permitted poor pregnancy outcomes to be prevented in 88.2% of cases.

About the authors

A P Kiryushchenkov

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies, Moscow

Email: masha-kimail@mail.ru
Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies, Moscow

D M Belousov

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies, Moscow

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies, Moscow

V N Veryasov

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies, Moscow

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies, Moscow

I V Menzhinskaya

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies, Moscow

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies, Moscow

M S Alekseyeva

Antenatal Clinic Six, Central Administration District, Moscow

Antenatal Clinic Six, Central Administration District, Moscow

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