The reproductive system in patients with acromegaly


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Abstract

Fifty-two patients with acromegaly were examined. Their reproductive disorders were ascertained to be induced by the suppressed synthesis of gonadotrophin hormones due to the tumor compression of the adenohypophysis or to the direct action of excess insulin-like growth factor-I that stimulated hyperplastic processes in the target organs, such as ovaries, the glandular epithelium of the breast and myometrium. The pattern of sexual organ lesions in patients with acromegaly includes menstrual disturbances, infertility, menopause praecox, hyperplastic processes. Close monitoring of the reproductive system, early detection of neoplasias, and correction of existing disorders are required during therapy for the underlying disease.

About the authors

Aleksey Vyacheslavovich Pronin

Email: Avpronin@gmail.com

A P Kiryushchenkov

G A Mel'nichenko

I D Khokhlova

N S Semenov

V S Pronin

E P Gitel'

A V Pronin

I. M. Sechenov Moscow Medical Academy

I. M. Sechenov Moscow Medical Academy

A P Kiryushchenkov

I. M. Sechenov Moscow Medical Academy

I. M. Sechenov Moscow Medical Academy

G A Melnichenko

I. M. Sechenov Moscow Medical Academy

I. M. Sechenov Moscow Medical Academy

I D Khokhlova

I. M. Sechenov Moscow Medical Academy

I. M. Sechenov Moscow Medical Academy

N S Semenov

I. M. Sechenov Moscow Medical Academy

I. M. Sechenov Moscow Medical Academy

V S Pronin

I. M. Sechenov Moscow Medical Academy

I. M. Sechenov Moscow Medical Academy

Ye P Gitel

I. M. Sechenov Moscow Medical Academy

I. M. Sechenov Moscow Medical Academy

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