Frequency of progesterone antibodies in sporadic spontaneous abortion


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Abstract

The study was performed in 84 women at 4-7-week gestational age. A study group included 64 patients with abnormal pregnancy (non-developing pregnancy, spontaneous miscarriage, anembryony, threatening miscarriage); a control group consisted of 20 women with physiological pregnancy. The levels of progesterone (PG) IgG and IgM antibodies, estradiol, PG, testosterone, T3, and T4 were measured. In complicated pregnancy, the frequency and the mean level of PG autoantibodies were 1.5-2 times higher than the physiological normal values. The risk of pregnancy loss significantly increases with the PG antibody level of more than 30 U/ml, particularly when a combination of IgM and IgG antibodies is detected. It is expedient to test for PG autoantibodies when repeat pregnant women with a history of abortion plan to conceive. The use of gestagens in complex therapy makes it possible to prevent threatening miscarriage.

About the authors

Zh A Mandrykina

Russian State Medical University, Russian Agency for Health Care

Russian State Medical University, Russian Agency for Health Care

I V Menzhinskaya

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies, Moscow

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies, Moscow

R I Ozerova

Russian State Medical University, Russian Agency for Health Care

Russian State Medical University, Russian Agency for Health Care

L S Rora

Russian State Medical University, Russian Agency for Health Care

Russian State Medical University, Russian Agency for Health Care

Yu E Dobrokhotova

Russian State Medical University, Russian Agency for Health Care

Email: doctoraibolit@rambler.ru
Russian State Medical University, Russian Agency for Health Care

References

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