Immunohistochemical study of matrix metalloproteinases and their tissue inhibitor in the hyperplastic endometrium in premenopausal women


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Abstract

The activity of components of the extracellular matrix in the hyperplastic endometrium was studied in 23 premenopausal patients, including 15 with simple endometrial hyperplasia, 8 with complex one, and 10 women without endometrial pathology on the basis of the immunohistochemical study of the expression of matrix metalloproteinases (MMP-1 and MMP-9) and tissue inhibitor of metalloproteinases (TIMP-1). The molecular biological processes of tissue remodeling in the hyperplastic endometrium were found to be characterized by the higher activity of MMP-1 and MMP-9 with the lower level of TIMP-1), resulting in the impaired processes of cyclic growth, differentiation, and death of uterine mucosal cells. The imbalance in the system of MMP and their inhibitor, which is detectable in simple endometrial hyperplasia, is aggravated in the endometrial samples with complex hyperplasia.

About the authors

Yu N Zadonskaya

Russian State Medical University, Russian Agency for Health Care

Russian State Medical University, Russian Agency for Health Care

N A Litvinova

Russian State Medical University, Russian Agency for Health Care

Email: doctoraibolit@rambler.ru
Russian State Medical University, Russian Agency for Health Care

T A Demura

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies, Moscow

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies, Moscow

L S Yezhova

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies, Moscow

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies, Moscow

Yu E Dobrokhotova

Russian State Medical University, Russian Agency for Health Care

Email: doctoraibolit@rambler.ru
Russian State Medical University, Russian Agency for Health Care

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