Use of Livarol (vaginal suppositories) to prevent chronic recurrent candidiasis caused by non-albicans Candida spp.


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Abstract

The paper gives the results of studying the efficacy and safety of Livarol (vaginal suppositories containing ketoconazole 400 mg) in preventing a relapse of chronic recurrent genital candidiasis caused by non-albicans Candida spp. Thirty women aged 18-59 years (mean 33.8±8.7 years) who had at least four relapses for a year and pathogens that are not Candida albicans, which had been confirmed by laboratory data, (a study group) were examined. A control group comprised 220 patients aged 18 to 62 years (mean 30.±8.7 years) who had not received preventive antirecurrent treatment. In the study group, the causative agents were C. krusei (27%), C. tropicalis (26%), and C. glabrata (23%); in the control group, these were C. albicans (83%), C. glabrata (5.2%), and C. krusei (4.8%). The clinical and mycological efficiency of the antirecurrent use of Livarol for 6 months was 93.4%. With the use of Livarol, a remission 12 months after relapse arrest was noted in 86.7% of the women in the study group and in 25% in the control group (p < 0.05).

About the authors

A K Mirzabalayeva

Saint Petersburg Medical Academy of Postgraduate Education, Russian Agency for Health Care

Кафедра клинической микологии, аллергологии и иммунологиидоктор медицинских наук, профессор; ГОУ ДПО Санкт-Петербургская медицинская академия последипломного образования Росздрава; Saint Petersburg Medical Academy of Postgraduate Education, Russian Agency for Health Care

O N Zhorzh

Russian State Medical Academy of Postgraduate Education, Moscow

Russian State Medical Academy of Postgraduate Education, Moscow

N N Klimko

Saint Petersburg Medical Academy of Postgraduate Education, Russian Agency for Health Care

Кафедра клинической микологии, аллергологии и иммунологии; ГОУ ДПО Санкт-Петербургская медицинская академия последипломного образования Росздрава; Saint Petersburg Medical Academy of Postgraduate Education, Russian Agency for Health Care

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