Use of plasmapheresis in multimodality therapy for postpartum endometritis

The aim of the study was to evaluate the efficiency of plasmapheresis used in puerperas with severe postpartum endometritis (PE). Sixty-one puerperas with severe PE were followed up. Of them, 31 patients received therapeutic plasmapheresis sessions (a study group) and 30 patients had traditional therapy for PE (a control group). Peripheral blood parameters, hemostatic state, and the levels of proinflammatory cytokines (IL-1β, IL-6, TNF-α) and C-reactive protein were determined. Incorporation of plasmapheresis into multimodality therapy for PE normalized the general condition of puerperas, reduced the count of white blood cells, and stab neutrophils, activated lymphocytes, and decreased platelet aggregability. The levels of the proinflammatory cytokines and C-reactive protein were significantly decreased in the study group patients. Plasmapheresis as part of multimodality therapy for PE makes it possible to achieve a considerable improvement in laboratory parameters and to favor a reduction in the degree of clinical manifestations of the disease and a more rapid cessation of its major symptoms.

postpartum endometritis, proinflammatory cytokines, hemostasis, plasmapheresis, antibiotics