HEALTH OF BABIES BORN AFTER IN VITRO FERTILIZATION


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Abstract

In the period 2004 to 2008, the authors studied the outcomes of 5386 labors after in vitro fertilization (IVF) at the Moscow maternity homes, Healthcare Department, of them 1726 labors at the Center of Family Planning and Reproduction (CFPR); 157 labors after controlled ovulation stimulation. The health status of 517 babies born at the CFPR in 2008was analyzed. That of 63 babies aged 1 year, who were treated at an intensive care unit after birth, was evaluated. The data available in the literature on higher perinatal mortality and perinatal morbidity rates in babies after IVF have been confirmed, which is largely determined by an increase in the incidence of multiple pregnancy by 15 times and preterm labor by more than 3 times as compared with that during spontaneous pregnancy. In premature babies, morbidity rates are 926.6 and 474,1%oo, respectively. After IVF, congenital malformations occur more frequently (6.6 versus 5,27%); there are no differences in chromosomal abnormality rates (0,28and 0,23%).

About the authors

G M SAVEL'EVA

Russian State Medical University, Russian Agency for Health Care, Moscow

Russian State Medical University, Russian Agency for Health Care, Moscow

M A KURTsER

E M KARAChUNSKAYa

M E MLADOVA

M A DRONOVA

Russian State Medical University, Russian Agency for Health Care, Moscow

Russian State Medical University, Russian Agency for Health Care, Moscow

G N BUSLAEVA

Russian State Medical University, Russian Agency for Health Care, Moscow

Russian State Medical University, Russian Agency for Health Care, Moscow

G M Savelyeva

2Center of Family Planning and Reproduction, Moscow Healthcare Department

2Center of Family Planning and Reproduction, Moscow Healthcare Department

M A Kurtser

2Center of Family Planning and Reproduction, Moscow Healthcare Department

2Center of Family Planning and Reproduction, Moscow Healthcare Department

Ye M Karachunskaya

2Center of Family Planning and Reproduction, Moscow Healthcare Department

2Center of Family Planning and Reproduction, Moscow Healthcare Department

M Ye Mladova

2Center of Family Planning and Reproduction, Moscow Healthcare Department

2Center of Family Planning and Reproduction, Moscow Healthcare Department

M A Dronova

Russian State Medical University, Russian Agency for Health Care, Moscow

Russian State Medical University, Russian Agency for Health Care, Moscow

G N Buslayeva

Russian State Medical University, Russian Agency for Health Care, Moscow

Russian State Medical University, Russian Agency for Health Care, Moscow

References

  1. Евсюкова И.И., Маслянюк Н.А. Состояние новорожденных и их дальнейшее развитие при многоплодной беременности после ЭКО // Пробл. репродукции. - 2005. - № 2. - 49-53.
  2. Здановский В.М., Витязева И.И. Течение и исход беременностей после лечения бесплодия методами вспомогательной репродукции (МВР) // Проблемы репродукции. - 2000. - № 3. - С. 55-56.
  3. Кириллова Е.А., Зарецкая Н.В., Никифорова О.К., Калинина Е.А. Цитогенетические исследования при беременностях после ЭКО. Тезисы XII Международной конференции «Вспомогательные репродуктивные технологии» // Пробл. репрод. - 2003. - № 5. -С. 42-43.
  4. Никитина И.В. Патологические состояния у новорожденных, родившихся в результате использования вспомогательных репродуктивных технологий (ЭКО и ПЭ, ЭКО и ИКСИ) : Автореф. дис. ... канд. мед. наук. - М., 2005.
  5. Boulet S.L., Schieve L.A., Nannini A. et al. Perinatal outcomes of twin births conceived using assisted reproduction technology: a population-based study // Hum. Reprod. - 2008. - Vol. 23, № 8. - Р. 1941- 1948.
  6. Bowdin S., Allen C., Kirby G. et al. A survey of assisted reproductive technology births and imprinting disorders // Hum. Reprod. - 2007. - Vol. 22, № 12. - Р. 3237-3240.
  7. Carson C, KurinczukJ.J., SackerA. Cognitive development following ART: effect of choice of comparison group, confounding and mediating factors // Hum. Reprod. - 2010. - Vol. 25, № 1. - Р. 244-252.
  8. Hansen M, Kurinczuk J., Bower C, Webb S. The risk of major birth defects after intracytoplasmatic sperm injection and in vitro fertilization // N. Engl. J. Med. - 2002. - Vol. 346. - № 10. - P. 725-730.
  9. Klemetti R., Sevon T, Gissler M. Health of children born as a result of in vitro fertilization // Pediatrics. - 2006 . - Vol. 118, № 5. - Р. 1819-1827.
  10. Koivurova S., Hartikainen A., Gissler M. Neonatal outcome and congenital malformations in children born after in-vitro fertilization // Hum. reprod . - 2002. - Vol. 17, № 5. - P. 1391-1398.
  11. Neelanjana M., Sabaratnam A. Malignant conditions in children born after assisted reproductive technology // Obstet. Gynecol. Surv. - 2008. - Vol. 63, № 10. - Р. 669-676.
  12. Porta-Ribera R., Tremols V., Munar-Mut C. J. et al. Monitoring neurodevelopment in children born as a result of using assisted reproduction techniques // Rev. Neurol. - 2009. - Vol. 49, № 9. - Р. 463- 466.
  13. Sutcliffe A.G., D'Souza S.W., Cadman J. et al. Minor congenital anomalies, major congenital malformations and development in children conceived from cryopreserved embryos // Hum. Reprod. - 1995. - Vol. 10, № 12. - Р. 3332- 3337.
  14. Wagenaar K., Huisman J., Cohen-Kettenis P.T. An overview of studies on early development, cognition, and psychosocial well-being in children born after in vitro fertilization // J. Dev. Behav. Pediatr. - 2008. - Vol. 29, № 3. - Р. 219-230.

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