RESULTS OF A COMPARATIVE RANDOMIZED TRIAL OF THE EFFICACY AND SAFETY OF CHLORHEXIDINE AND METRONIDAZOLE IN THE TREATMENT OF BACTERIAL VAGINOSIS

In accordance with the international good clinical practice (GCP) rules, an open randomized comparative trial was conducted to study the efficacy and safety of Hexicon (chlorhexidine) and Flagyl (metronidazole) vaginal suppositories in the treatment of bacterial vaginosis (BV). A total of 60 reproductive-age women with BV participated in the trial. Bacterial culture tests and vaginal discharge microscopy for the pathological flora and lactobacilli were carried out in all the patients. The patients were divided into 2 groups: 1) 30 women taking chlorhexidine suppositories and 2) 30 women receiving metronidazole ones. The groups were stratified between them. Both drugs were found to be highly effective in normalizing the values of pH and amino test of vaginal discharge and the data of vaginal content microscopy (no key cells). Bacteriological studies suggested normalized vaginal microcenosis: restoration of the lactoflora and elimination of opportunistic microorganisms. In the physicians' opinion, excellent and good effects were noted (immediately after treatment) in 96.7 and 83.3% in Groups 1 and 2, respectively (p>0,05). Following one-month therapy, a positive effect was recorded in 96.7% in Group 1 and in 93.4% in Group 2.
Hexicon (chlorhexidine) was shown to be an effective alternative in therapy for BV

bacterial vaginosis, suppositories containing chlorhexidine and metronidazole.