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No 6 (2010)

Articles

EKLAMPSIYa V SOVREMENNOM AKUShERSTVE

SAVEL'EVA G.M., ShALINA R.I., KURTsER M.A., ShTABNITsKIY A.M., KURTENOK N.V., KONOVALOVA O.V.

Abstract

The objective of the study was to define ways of reducing the frequency of eclampsia and its severe complications. The authors analyzed 113 histories of deliveries occurring in patients with severe gestosis and eclampsia at Moscow maternity homes in 2006-2008, the 2008 records of obstetric facilities of the Russian Federation, and the data available in the literature. The main errors in the treatment of preeclampsia and eclampsia were the underestimation of the patients' status and no notification of the symptoms of preeclampsia (19-36%), insufficient and inadequate anticonvulsive therapy (13-85%), polypragmasia (56%), high administered fluid volumes with a predominance of colloids (25.4%), inadequate labor analgesia (82.7%), and inadequate postpartum therapy (12-87%). The reduction in the frequency of eclampsia and its complications is determined by the timely diagnosis and treatment of the conditions preceded its development. To follow the management protocols elaborated for patients with severe gestosis and eclampsia is excessively important
Obstetrics and Gynecology. 2010;(6):4-9
pages 4-9 views

FETOPLACENTAL ANGIOGENESIS DURING NORMAL PREGNANCY: A ROLE OF PLACENTAL GROWTH FACTOR AND ANGIOPOIETINS

PAVLOV K.A., DUBOVA E.A., ShchEGOLEV A.I., Pavlov K.A., Dubova Y.A., Shchegolev A.I.

Abstract

The paper gives the data available in the literature on a role of placental growth factor and angiopoietins in fetoplacental angiogenesis. Emphasis is laid on the implication of angiopoietin receptors in the formation of placental vasculature and accordingly in the normal development of pregnancy.
Obstetrics and Gynecology. 2010;(6):10-15
pages 10-15 views

THE SKIN AND SEX HORMONES (THE EFFECTS OF MENOPAUSE AND HORMONE REPLACEMENT THERAPY)

YuRENEVA S.V., IL'INA L.M., MULLABAEVA S.M., Yureneva S.V., Ilyina L.M., Mullabayeva S.M.

Abstract

Estrogen deficiency accelerates skin aging processes in postmenopausal women and vice versa hormone replacement therapy (HRT) alleviates them and even may promote the regression of many poor alterations. The review presents data on that there is an association of the impact of skin aging and postmenopausal estrogen deficiency and HRT on these processes.
Obstetrics and Gynecology. 2010;(6):16-22
pages 16-22 views

THE MORPHOLOGICAL AND MOLECULAR GENETIC FEATURES OF NEOANGIOGENESIS IN THE UTERINE CICATRICIAL TISSUE OF PATIENTS WITH UNDIFFERENTIATEDCONNECTIVE TISSUE DYSPLASIA

SUKhIKh G.T., KOGAN E.A., KESOVA M.I., DEMURA T.A., DONNIKOV A.E., MARTYNOV A.I., TROFIMOV D.Y., KLIMANTsEV I.V., SANNIKOVA M.V., KAN N.E., KOSTIN P.A., ORDZhONIKIDZE N.V., AMIRASLANOV E.Y., Sukhikh G.T., Kogan Y.A., Kesova M.I., Demura T.A., Donnikov A.Y., Martynov A.I., Trofimov D.Y., Klimantsev I.V., Sannikova M.V., Kan N.Y., Kostin P.A., Ordzhonikidze N.V., Amiraslanov E.Y.

Abstract

The investigation was undertaken to study the morphological and molecular genetic features of uterine cicatricial neoangiogenesis in patients with undifferentiated cervical dysplasia (uCD). The study included 95 patients aged 18 to 37 years with uterine scar after cesarean section. Inadequate scars in uCD were found to be characterized by the relatively decreased level of angiogenesis, which may lead to connective tissue disorganization caused by local ischemia. The carriage of the 936C allele and the -634C/C genotype of the VEGF-A gene is likely to be one of the genetic risk factors for the development of intramural hematomas.
Obstetrics and Gynecology. 2010;(6):23-27
pages 23-27 views

ARGON PLASMA COAGULATION OF TISSUES DURING CESAREAN SECTION

RADZINSKIY V.E., ESIPOVA L.N., VUChENOVICh Y.D., Radzinsky V.Y., Yesipova L.N., Vuchenovich Y.V.

Abstract

The paper presents the experience with argon plasma coagulation used in 646 women aged 22 to 44 years during cesarean section. It describes the technical aspects of complex technology of cesarean section. The study has shown that argon plasma coagulation produces prompt hemostasis and reduces the volume of blood loss, the degree of pain syndrome, and the length of hospital stay.
Obstetrics and Gynecology. 2010;(6):28-29
pages 28-29 views

THE THERAPEUTIC AND DIAGNOSTIC MANAGEMENT TACTICS FOR PREGNANT WOMEN WITH ARTERIAL HYPERTENSION IN RUSSIA: TREATMENT POLICY (RESULTS OF THE DIALOG II MULTICENTER EPIDEMIOLOGICAL STUDY)

OGANOV R.G., TKAChEVA O.N., Tkacheva O.N.

Abstract

The DIALOG II was conducted to examine therapeutic management tactic in pregnant women with arterial hypertension and the pharmacoepidemiology of antihypertensive agents used in pregnant women in Russia versus the results of the 2005- 2006 DIALOG I study. A total of2033 physicians from 27 cities and town of Russia were interviewed by a questionnaire. The study has indicated that in real clinical practice there are no generally accepted criteria for the start of antihypertensive therapy; 7.4% of the physicians continue to prescribe ACE inhibitors and other unrecommended agents to pregnant women; for the treatment of arterial hypertension, almost 80% of the physicians use drugs that are not properly antihypertensive.
Obstetrics and Gynecology. 2010;(6):30-36
pages 30-36 views

IMPACT OF DELIVERY IN PREGNANT WOMEN WITH ANEMIAS ON THE ADAPTATION AND FUNCTIONAL STATE OF THE AUTONOMIC NERVOUS SYSTEM IN THE NEWBORN INTHE EARLY NEONATAL PERIOD

DEREVTsOV V.V., Derevtsov V.V.

Abstract

The paper gives the results of studying the adaptation and functional state of the autonomic nervous system in the early neonatal period in babies born to mothers with anemias in relation to delivery options. One hundred and six neonates, including 81 babies born to mothers with anemias (of them 26 and 55 babies were born by cesarean section and vaginal delivery, respectively) and 25 infants born to mothers without anemia by vaginal delivery, were examined. The autonomic nervous system was judged from the results of physical examinations and the data of electrocardiography and cardiointervalography carried out by the standard procedures. Pacemaker migration and arrhythmia were more frequently recorded at birth in the presence of enhanced sympathetic activity and impaired adaptation. Minimal exercise in babies born via vaginal delivery led to their body's exhaustion. On day 5 of life in the presence of diminished sympathetic activity, the infants born to mothers with anemias via cesarean section retained the previously detected changes in the pattern of cardiac arrhythmias and showed a rise in the incidence of tachy- and bradycardia and those who were born by vaginal delivery had an increase in the incidence of tachycardia. The exercise test was suggestive of an adequate response to exercise, which was manifested by more pronounced activation of the sympathetic nervous system and by the tension of adaptation. The established fact justifies the need for a follow-up of babies born to mothers with anemias, with the assessment of their health status and additional examinations in the critical age periods of development until compensation of detected impairments occurs. A list of therapeutic measures against the progression of found changes is given.
Obstetrics and Gynecology. 2010;(6):37-43
pages 37-43 views

VALUE OF IMMUNOHISTOCHEMICAL DETERMINATION OF BIOMARKERS IN SQUAMOUS INTRAEPITHELIAL LESIONS OF THE CERVIX UTERI

KONDRIKOV N.I., ShAMARAKOVA M.V., GORBAChEVA Y.V., Kondrikov N.I., Shamarakova M.V., Gorbacheva Y.V.

Abstract

Изучали экспрессию биомаркеров Ki-67 и р16INK4a при плоскоклеточных интраэпителиальных поражениях шейки матки. Установлено достоверное различие в экспрессии биомаркера пролиферации Ki-67 в неизмененном многослойном плоском эпителии шейки матки и плоскоклеточных интраэпителиальных поражениях высокой степени, а также в плоскоклеточной карциноме (р<0,5). Что касается экспрессии р16INK4a, то достоверные различия обнаружены между плоскоклеточными интраэпителиальными поражениями низкой степени, а также высокой степени и плоскоклеточной карциномой шейки матки. Сочетанное определение Ki-67 и рШ™4" способствует более полноценному определению биологической сущности патологического процесса в эпителии шейки матки. Иммуногистохимическое исследование данных маркеров поможет не только более качественной диагностике поражения, но и выбору необходимого объема лечебных мероприятий
Obstetrics and Gynecology. 2010;(6):44-49
pages 44-49 views

VALUE OF THE LOCAL USE OF INTERFERON'S INDUCTOR IN THE COMPLEX TREATMENT OF WOMEN WITH PAPILLOMAVIRUS INFECTION

KUNTsEVICh L.D., ShIBAEVA E.V., KOMAROVA V.D., KOPYTOVA T.V., PYShKINA E.I., ShchELChKOVA N.A., Kuntsevich L.D., Shibayeva Y.V., Komarova V.D., Kopytova T.V., Pyshkina Y.I., Shchelchkova N.A.

Abstract

The efficiency of complex treatment was studied in female patients with anogenital warts who received cycloferon intramuscularly or by electrophoresis. Two groups of women with the clinical manifestations of papillomavirus infection were followed up. Group 1 patients (n = 62) received 5-10 intramuscular cycloferon indections (2 ml of its solution on alternate days in the complex treatment; Group 2 (n = 33) had the agent ingections (2 ml of its solution every other or two days) as 5 sessions via electrophoresis applied to the vulval area. Vaginal secretions were tested for local cytokines (а-interferon, y-interferon, and lactoferrin) before and after treatment. Focal immune physiotherapy with cycloferon in the complex treatment versus its intramuscular administration in women with anogenital warts reduces the likelihood of recurrences of the disease by more than 3 times, promotes the activation of local cytokines (а-interferon, y-interferon, and lactoferrin), is well tolerated and painless. Focal immune psysiotherapy with cycloferon may be the method of choice in treating the clinical manifestations of papillomavirus infection in women.
Obstetrics and Gynecology. 2010;(6):49-53
pages 49-53 views

PREVENTION OF METABOLIC SYNDROME AFTER MEDICAL ABORTION

SEROV V.N., ZAVALKO A.F., Serov V.N., Zavalko A.F.

Abstract

The development of metabolic syndrome after abortion was traced by the data of a prospective study covering 300 women who had been allocated into high- and low-risk groups. The study assessed their menstrual cycle, the level of situation and personality anxieties, biochemical parameters characterizing carbohydrate and fat metabolisms and serum oxidative activity. The efficiency of magnetic laser therapy used to correct metabolic disturbances was analyzed. An algorithm was proposed for the management of women admitted for artificial pregnancy interruption.
Obstetrics and Gynecology. 2010;(6):54-59
pages 54-59 views

OPYT PRIMENENIYa «MYaGKIKh» SKhEM STIMULYaTsII SUPEROVULYaTsII U PATsIENTOK GRUPPY RISKA RAZVITIYa SINDROMA GIPERSTIMULYaTsIIYaIChNIKOV

Kalinina E.A., Ebzeeva M.V., Kuz'michev L.N., Kalinina Y.A., Ebzeyeva M.V., Kuzmichev L.N.

Abstract

The paper presents the results of a study to enhance the efficiency and safety of in vitro fertilization (IVF) programs in patients at high risk for ovarian hyperstimulation syndrome (OHSS), by applying the modified protocols. In 50 study group patients, the ovaries were stimulated by the mild regimen using low-dose (75-150 IU) recombinant follicle-stimulating hormone (rFSH) from day 5 of their menstrual cycle; in a control group comprising 25 patients, the IVF program was implemented by a short protocol from day 2-3 of their menstrual cycle, by administering the standard doses of rFSH (150-225 IU). The daily and course doses of the inductor, the number of growing and dominant follicles, obtained oocytes and embryos, their quality, and the incidence rates of OHSS were estimated. The number of growing follicles was 9.2±1.8 and 12.2±2.4 in the study and control groups, respectively; the daily dose of the inductor was 125.5±45.7 and 175±25.8 IU; its course dose was 950±157.4 and 1405±178.2 IU; the obtained oocytes averaged 7.5±1.2 and 12.1±1.3; the fertilization rate was 65.1 and 78.5%; pregnancy occurred in 22.8 and 28.3% of cases, respectively; embryo transfer had to be cancelled due to a risk for OHSS in 8 and 12% of the patients, respectively. It is expedient to use mild superovulation regimens in OHSS-risk group patients.
Obstetrics and Gynecology. 2010;(6):60-64
pages 60-64 views

MAGNETIC VIBRATION MASSAGE AND IONOPHORESISIN THERAPY FOR CHRONIC CYSTITIS IN POSTMENOPAUSAL WOMEN

Salov I.A., Khashaeva T.K., Duganova M.O., Karagezyan K.M., Shagerbieva E., Raygorodskiy Y.M.

Abstract

Seventy-six patients (mean age 66.4 years) with chronic recurrent cystitis were examined to provide a rationale for whether local therapy might be performed for chronic recurrent cystitis in postmenopausal women. Local hormone replacement therapy was performed along with the traditional therapy in a control group. In a study group, local hormone replacement therapy was supplemented by vaginal magnetic vibration and the traditional systemic antibacterial therapy was replaced by local (ionophoresis) one. All physiotherapy options were performed using a Russian AMUS-01-INTRAMAG device with a Rectomassager attachment. Immunoassay of vaginal discharges and bacterial and clinical studies revealed the benefits of local therapy with physical exposures. In the study group, the integral therapeutic effectiveness index was 1.8 times greater than that in the control group.
Obstetrics and Gynecology. 2010;(6):65-69
pages 65-69 views

OPTIMIZATION OF LOCAL THERAPY FOR VAGINAL INFECTIONS AND DYSBIOSES

Nesterov I.M., Aylamazyan E.K., Areg A.T., Nesterov I.M., Ailamazyan E.K., Areg A.T.

Abstract

The authors investigated the clinical and immunological efficacy of the interferon inducer 5% cycloferon liniment (Scientific Technological Pharmaceutical Firm «Polysan», Saint Petersburg) during intravaginal monotherapy for nonspecific vaginitis (NV), Candida vaginitis (CV), and bacterial vaginosis (BV), as well as its immunomodulatory effect. During a prospective study, the total clinical and microbiological efficiencies of a course of therapy were 74%; in the clinical groups, it was 68.2% for NV, 93.7% for BV, and 75% for CV. A placebo-controlled study showed that the clinical efficacy of the agent was 88.8%; there was a 2.6-fold reduction in the total incidence of the pathological types of vaginal biocenosis as compared to placebo. The drug is well tolerated by the patients; it causes no allergic reactions or other adverse events. The basic mechanism of the drug's immunomodulatory effect is to affect local vaginal immunity and it is manifested by the following immunological changes in vaginal secretions: an increase in vaginal tissue-blood barrier permeability; compensation for baseline diminished local IgG and IgA synthesis not only due to the higher diffusion of immunoglobulins from the bloodstream, but also due to the normalization and increase of their local synthesis. The use of the agent as a basic drug is promising and warranted during a course of immune-oriented therapy for infectious and inflammatory diseases and dysbioses of the lower female genital tract. The main use regimen for 5% cycloferon liniment to correct vaginal microbiocenosis is as follows: daily intravaginal instillations of 5 ml for 10 days.
Obstetrics and Gynecology. 2010;(6):70-75
pages 70-75 views

CHRONIC RECURRENT GENITAL CANDIDIASIS IN WOMEN: THERAPEUTIC AND PROPHYLACTIC TACTICS

Mirzabalaeva A.K., Dolgo-saburova Y.V., Mirzabalayeva A.K., Dolgo-Saburova Y.V.

Abstract

The paper gives data on the etiology, some aspects of pathogenesis, diagnosis, and treatment of chronic recurrent genital candidiasis. It considers the possibilities of prophylactic use of antimycotics during antimicrobial chemotherapy.
Obstetrics and Gynecology. 2010;(6):76-79
pages 76-79 views

NEW CAPACITIES OF IMMUNOMODULATORY THERAPY FOR CHRONIC RECURRENT GENITAL CANDIDIASIS AND PAPILLOMAVIUS INFECTION

ZhORZh O.N., MIRZABALAEVA A.K., Zhorzh O.N., Mirzabalayeva A.K.

Abstract

The paper presents data on the incidence of papillomavirus infection of the cervix uteri in patients with chronic recurrent genital candidiasis (CRGC). Its mycotic diagnosis was verified by mycological studies. Human papillomavirus (HPV) was detected by polymerase chain reaction diagnosis and genotyping. The specific features of impaired innate local immunity in CRGC and the immunotropic effect of HPV, which favors the recurrent or persistent course of the above infections, are discussed. The expediency of using immunomodulators (inosine pranobex - groprinosin) for the optimization of treatment is justified.
Obstetrics and Gynecology. 2010;(6):80-84
pages 80-84 views

KLINIKO-PATOGENETIChESKIE OSOBENNOSTI FIBROZNO-KISTOZNOY BOLEZNI MOLOChNOY ZhELEZY U PATsIENTOK S LEYOMIOMOY MATKI I ADENOMIOZOM

KOGAN E.A., IDRISOVA E.A., GURIEV T.D., UNANYaN A.L., BABGOEVA O.K.

Abstract

The study deals with the clinical and pathogenetic features of fibrocystic disease (FCD) in women with concomitant gynecological diseases (uterine leiomyoma and adenomyosis). Prospective and retrospective studies were conducted in 133 patients with FCD, including 98 patients with FCD concurrent with uterine leiomyoma and adenomyosis and 35 women without uterine pathology (uterine leiomyoma and/or adenomyosis). Pathomorphological and immunohistochemical studies were performed. The patients with FCD concurrent with uterine leiomyoma and adenomyosis showed the higher proliferative activity of the breast glandular epithelium in the foci of FCD as judged from Ki-67; the higher production of epidermal growth factor and its receptor, as well as increased insulin-like growth factor II receptor expression. The relative autonomy of FCD was revealed in patients with concomitant uterine leiomyoma and adenomyosis due to the expression of estrogen receptors and possible endogenous estradiol (COX-2) synthesis, which in combination with high progesterone receptor levels potentiates proliferation. The study indicated that FCD in women with concomitant gynecological diseases (leiomyoma and adenomyosis) was characterized by clinical, ultrasound, morphological, and immunohistochemical features. The frequent concurrence of breast and uterine diseases is due to the common, identical links of their pathogenesis: the enhancement of proliferative, angiogenic activity and the specific features of progesterone and estrogen receptor expression. The detection of endo- and myometrial pathological processes is a guide for a more careful diagnostic search for pathological processes in the breast. The patients with concomitant breast and uterine diseases should be referred to a higher risk group for reproductive cancers.
Obstetrics and Gynecology. 2010;(6):85-90
pages 85-90 views

SRAVNITEL'NAYa OTsENKA EFFEKTIVNOSTI DEYSTVIYa RAZLIChNYKh DOZ STATINOV NA OChAGI ENDOMETRIOZA PRI EGO EKSPERIMENTAL'NOY MODELI

ADAMYaN L.V., OGLY GULIEV M.T., ZAyRAT'YaNTs O.V., ARSLANYaN K.N., MAKSIMOVA Y.V.
Obstetrics and Gynecology. 2010;(6):91-96
pages 91-96 views

MATERNAL MORTALITY DURING PRETERM DELIVERY

TOKOVA Z.Z., TETRUAShVILI N.K., AN A.V., Tokova Z.Z., Tetruashvili N.K., An A.V.

Abstract

The study analyzed report schedules and the explanatory notes by principal obstetricians-gynecologists of the subjects of the Russian Federation about maternal death cases. Among the dead mothers in Russia in 2008, puerperas and parturients were 69.4%; of them 31.3% died at premature labor. The study has indicated that premature delivery with their population frequency of 3.4% is responsible for 21.7% of maternal death cases. In this connection, prevention of premature labor is a tool to reduce maternal mortality rates.
Obstetrics and Gynecology. 2010;(6):97-101
pages 97-101 views

COMPARATIVE ASSESSMENT OF MORBIDITY AND EARLY NEONATAL MORTALITY IN THE SUBJECTS OF THE RUSSIAN FEDERATION TO PROVIDE A SCIENTIFIC RATIONALE FOR THE OPTIMIZATION OF NEONATAL CARE

SOROKINA Z.K., Sorokina Z.K.

Abstract

The paper presents the results of an objective comparative assessment of the rates of early neonatal mortality (ENM) and the pattern of diseases that are major causes of neonatal death in the subjects of the Russian Federation. The regional ENM differences obtained differentially for full-term and premature neonates could reveal the basic problems and priority of a maternal and child health care service in the subjects of the Russian Federation. A number of regions were used as an example to demonstrate the possibilities of optimizing the care quality indices, which were based on the introduction of new, effective organization and control forms providing the timelessness and continuity of highly skilled care to pregnant women, parturients, and newborn babies. The findings make it possible to justify a number of proposals to develop a regional model for upgrading medical care to neonates.
Obstetrics and Gynecology. 2010;(6):102-108
pages 102-108 views

TRANSPORTIROVKA NOVOROZhDENNYKh S POROKAMI RAZVITIYa PRI RAZLIChNYKh MODELYaKh ORGANIZATsII MEDITsINSKOY POMOShchI

KhAMATKhANOVA E.M., KUChEROV Y.I., FROLOVA O.G., MOROZOV D.A.
Obstetrics and Gynecology. 2010;(6):109-113
pages 109-113 views
pages 114-118 views

REHABILITATION OF WOMEN AFTER MEDICAL ABORTION

SANDAKOVA E.A., SKRYaBINA V.V., RYLOVA O.V., Sandakova Y.A., Skryabina V.V., Rylova O.V.

Abstract

The paper presents the results of studying the efficacy of the herbal drug mastodinone in the rehabilitation of women after medical abortion. Fifty primigravidas aged 18 to 40 years without a history of menstrual dysfunction were examined immediately after medical abortion at 5-12 weeks of gestation. A study group (n = 30) received mastodinone only as 30 drops twice daily for 6 months; a control group (n=20) was untreated. The patients kept a menstrual calendar, by rating the manifestations of premenstrual-tension syndrome, the rhythm and volume of menstrual blood loss, and breast pain. Following 3 months, there were breast pain complaints in 23.3% of the women in the study group and in 60% in the controls; complaints of fatigability and lower abdominal pain were reported by 13.3 and 35% and 10 and 20%, respectively. Hyperpolymenorrhea, irritability, and insomnia were not observed in the study group; these were seen in 15; 60, and 5% of cases, respectively. Six months after abortion, complaints were virtually absent in the study group women. All non-rehabilitation women made these or those complaints: facial edemas (25%), irritability (40%), mastodynia (50%), fatigability (45%), and headache (25%). No cases of mastodinone-associated complications or adverse reactions were recorded.
Obstetrics and Gynecology. 2010;(6):119-122
pages 119-122 views

RESULTS OF A COMPARATIVE RANDOMIZED TRIAL OF THE EFFICACY AND SAFETY OF CHLORHEXIDINE AND METRONIDAZOLE IN THE TREATMENT OF BACTERIAL VAGINOSIS

KIRA E.F., GAMIROVA E.V., GAyTUKIEVA R.A., BELYaKINA I.V., Kira E.F., Gamirova E.V., Gaitukiyeva R.A., Belyakina I.V.

Abstract

In accordance with the international good clinical practice (GCP) rules, an open randomized comparative trial was conducted to study the efficacy and safety of Hexicon (chlorhexidine) and Flagyl (metronidazole) vaginal suppositories in the treatment of bacterial vaginosis (BV). A total of 60 reproductive-age women with BV participated in the trial. Bacterial culture tests and vaginal discharge microscopy for the pathological flora and lactobacilli were carried out in all the patients. The patients were divided into 2 groups: 1) 30 women taking chlorhexidine suppositories and 2) 30 women receiving metronidazole ones. The groups were stratified between them. Both drugs were found to be highly effective in normalizing the values of pH and amino test of vaginal discharge and the data of vaginal content microscopy (no key cells). Bacteriological studies suggested normalized vaginal microcenosis: restoration of the lactoflora and elimination of opportunistic microorganisms. In the physicians' opinion, excellent and good effects were noted (immediately after treatment) in 96.7 and 83.3% in Groups 1 and 2, respectively (p>0,05). Following one-month therapy, a positive effect was recorded in 96.7% in Group 1 and in 93.4% in Group 2. Hexicon (chlorhexidine) was shown to be an effective alternative in therapy for BV
Obstetrics and Gynecology. 2010;(6):123-129
pages 123-129 views

OTsENKA EFFEKTIVNOSTI FITOESTROGENOV V LEChENII KLIMAKTERIChESKOGO SINDROMA

VOyChENKO N.A., AKARAChKOVA E.S., MYChKA V.B., USPENSKAYa Y.B., KIRILLOVA M.Y., KUZNETsOVA I.V., TOLSTOV S.N.
Obstetrics and Gynecology. 2010;(6):130-134
pages 130-134 views

TREATMENT OF ANEMIA IN GYNECOLOGICAL PATIENTS

OZOLINYa L.A., BOLDINA E.B., Ozolinya L.A., Boldina Y.B.

Abstract

The new drug Cosmofer that is an iron(III)-hydroxide low-molecular-weight dextran complex and a chemically similar analogue of the physiological complex of ferritin with iron(III)-hydroxide has been used to treat 30 patients with iron-deficiency anemia caused by menorrhagias in the presence of endometrial hyperplasia and uterine myoma. Before treatment, hemoglobin levels in the patients ranged from 65 to 80 g/l (mean 70.1±3.5 g/l). The drug was intravenously injected dropwise in a dose of 100 mg (2 ml) every other day (thrice weekly). The course of therapy was 3 to 5 infusions; the total dose of iron administered was 300 to 500 mg. After Cosmofer treatment, the mean level of hemoglobin was as high as 98.1+2.8 g/l, which is indicative of the high clinical efficacy of the drug in the treatment of iron-deficiency and posthemorrhagic anemias in gynecological patients.
Obstetrics and Gynecology. 2010;(6):135-139
pages 135-139 views

COMPLEX TREATMENT FOR POINTED CONDYLOMAS

AVER'YaNOVA M.G., Averyanova M.G.

Abstract

The paper analyzes the time course of changes in the clinical symptoms of papillomavirus infection and complaints associated with condyloma destruction. The therapy involved glycyrrhizinic acid treatment and local destructive therapy of anogenital warts with a physical technique, such as laser therapy on a ЛХК-20-01 «Lancet-2» device. Local therapy with glycyrrhizinic acid is warranted before and after surgery.
Obstetrics and Gynecology. 2010;(6):140-142
pages 140-142 views

PRINCIPLES OF INFUSION-TRANSFUSION THERAPY FOR MASSIVE OBSTETRICCOAGULOPATHIC HEMORRHAGES

FEDOROVA T.A., ROGAChEVSKIy O.V., AN A.V., Fedorova T.A., Rogachevsky O.V., An A.V.

Abstract

The clinical lecture is devoted to the main issues in the pathogenesis of massive postpartum coagulopathic hemorrhage with the development of hemorrhagic stroke and disseminated intravascular coagulation. It presents the basic principles of infusion-transfusion therapy for postpartum coagulopathic hemorrhages, its volumes, quality, and sequence. Adequate timely intensive infusion-transfusion therapy, the use of the current blood-saving technologies and new hemostatic agents in the treatment of massive obstetric hemorrhages in puerperas make it possible to save a woman's life, to implement organ-saving tactic, and to improve quality-of- life parameters. The clinical lecture is intended for obstetricians-gynecologists, anesthesiologists-resuscitation specialists, transfusiologists who work at perinatal centers, maternity homes, multidisciplinary hospitals, in the units of transfusiology of multidisciplinary health care facilities.
Obstetrics and Gynecology. 2010;(6):143-150
pages 143-150 views

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