COMPARATIVE ANALYSIS OF FOLLITROPIN ALPHA OVULATION STIMULATION IN THE USE OF GONADOTROPIN-RELEASING HORMONE AGONISTS OR HIGH-DOSE ETHINYL ESTRADIOL IN PATIENTS WITH PREMATURE OVARIAN FAILURE
- Authors: MARCHENKO L.A1, ZHAKHUR N.A1, BUTAREVA L.B1, KUZMICHEV L.N1, MIKAELYAN V.G1
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Affiliations:
- Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia
- Issue: No 2 (2011)
- Pages: 65-69
- Section: Articles
- URL: https://journals.eco-vector.com/0300-9092/article/view/246513
- ID: 246513
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Abstract
Objective. To comparatively analyze two ovulation stimulation schemes in patients with premature ovarian failure. Subjects and methods. The study enrolled 35 patients aged 22 to 40 years with premature ovarian failure; in 18 of them the ovaries were stimulated with follitropin alpha after pituitary pre-desensitization with gonadotropin-releasing hormone agonists (Group 1) and in 17 this was done with the same agent in the use of high-dose ethinyl estradiol (Group 2). Clinical, laboratory, and ultrasound studies were performed and the hormonal profile was evaluated. Results. A positive effect was achieved in 4 and 2 patients in Groups 1 and 2, respectively (p > 0.05). Pregnancy occurred in none case. The estrogenic scheme contributed to a more physiological response of the ovaries; however, it caused a significantly larger number of adverse reactions. Conclusion. Today the use of donor oocytes remains the only highly effective method to treat infertility in this contingent of patients, which may be extensively employed in day-to-day clinical practice.
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About the authors
L. A MARCHENKO
Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia
N. A ZHAKHUR
Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia
Email: adnanati@mail.ru
L. B BUTAREVA
Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia
L. N KUZMICHEV
Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia
V. G MIKAELYAN
Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia
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