LEVEL OF CYTOKINES IN THE CERVICAL SECRETIONS OF PREGNANT WOMEN WITH BACTERIAL VAGINOSIS


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Abstract

Development of Russia, Moscow Objective. To determine cervical secretion pro- and anti-inflammatory cytokines as indicators of local immunity in pregnant women with bacterial vaginosis (BV). Subjects and methods. The study enrolled 45 pregnant women seeking medical advice in early gestation. A study group included 32 pregnant women with the verified diagnosis of BV; a comparison group consisted of 13 pregnant women with normal vaginal microbiocenosis. The levels of pro- (TNF-а, IFN-y, IL-1a, IL-2, IL-6, and IL-8) and anti-inflammatory (IL-4 and IL-10) cytokines were measured in the cervical canal mucus. Results. Pretreatment local immunity in pregnant women with BV showed a significant increase in the levels of pro- and anti-inflammatory cytokines in reference to their production in pregnant women with normal vaginal microcenosis. After BV treatment, the content of cytokines approximated those in healthy pregnant women; however, the levels of TNF-а and IL-8 changed little, which would be accounted for by the low production of these cytokines since the leukocytic reaction is not marked in the vaginal epithelial locus in vaginosis. Conclusion. Qualitative and quantitative changes in the levels of cytokines reflect the activation of immunocompetent cells during any pathological process. The f indings suggest certain autonomy of immune reactions in the lower female genital tract.

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T. E KARAPETYAN

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social

Email: tomamed02@mail.ru

L. V KRECHETOVA

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social

M. M ZIGANSHINA

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social

L. V VANKO

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social

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