PROGNOSTIC CRITERIA FOR SUCCESSFUL OVULATION INDUCTION N PATIENTS WITH PREMATURE OVARIAN FAILURE
- Authors: ZHAKHUR N.A1, MARCHENKO L.A1, BUTAREVA L.B1, KUZMICHEV L.N1, KINDAROVA L.B1
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Affiliations:
- Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia
- Issue: No 4 (2011)
- Pages: 50-55
- Section: Articles
- URL: https://journals.eco-vector.com/0300-9092/article/view/246516
- ID: 246516
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Abstract
Objective. To search for possible prognostic criteria for successful ovulation induction in patients with premature ovarian failure (POF). Subjects and methods. The results of ovulation induction were retrospectively analyzed in 35 patients with POF. All the patients had previously undergone a full clinical and laboratory examination. According to their treatment response, the patients were divided into 3 groups: A) 23 patients without activation of folliculogenesis; B) 6 patients with growth of follicles greater than 10 mm, but their subsequent atresia, and C) 6 patients with verified ovulation. Results. Comparison of women with ovulation and without follicular growth revealed statistically significant differences in the following indicators: mean age at amenorrhea onset (26.8±6.2 and 32.0±3.35 years, respectively; p=0.036); rate of the familial form of the disease (33.3 and 3.4%, respectively; p=0.017), autoimmune comorbidity (0 and 48.3%, respectively p = 0.008); mean blood testosterone levels (1.07±0.5 and 0.69±0.1 nmol/l, respectively; p=0.03); detection rate for perioophoritis (0 and 35.3%, respectively; p=0.037). The relative risk of a poor ovarian response to stimulation showed 7- and 3.6-fold increases in autoimmune comorbidity and in the detection of perioophoritis, respectively. No statistically significant differences were found between the groups in baseline blood anti-Müllerian hormone (AMH) levels and ovarian volume. Conclusion. Later onset irrespective of the duration of amenorrhea, its family form, no autoimmune comorbidity, and higher blood total testosterone concentrations (more than 1 nmol/l) may be good predictors of ovulation induction in patients with POF. The generally accepted criteria for predicting ovarian response in patients with preserved menstrual function (serum AMH level, ultrasonographic ovarian volumes) in patients with POF cannot be regarded as significant.
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About the authors
N. A ZHAKHUR
Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia
L. A MARCHENKO
Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia
Email: l_marchenko@oparina4.ru
L. B BUTAREVA
Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia
L. N KUZMICHEV
Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia
L. B KINDAROVA
Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia
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