A PROBLEM IN THE UNREGULATED USE OF INTRAVENOUS IMMUNOGLOBULIN IN OBSTETRICS


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Abstract

Intravenous immunoglobulin belongs to the drugs most frequently used for unregistered indications, including obstetric ones. A review of published clinical trials and meta-analyses does not make it possible to recommend its use in women with recurrent miscarriage of unknown etiology and in pregnant women with antiphospholipid syndrome and to improve the results of in-vitro fertilization in those with a history of unsuccessful implantation. The use of intravenous immunoglobulin for these indications is considered by experts as investigatory and recommended only within the framework of randomized clinical trials.

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About the authors

E. A USHKALOVA

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia

Email: eushk@yandex.ru

E. M SHIFMAN

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia

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