USE OF ANTIPYRETICS AND ANALGESICS DURING PREGNANCY: RESULTS OF THE FIRST ALL-RUSSIAN PHARMACOEPIDEMIOLOGICAL STUDY «EPIDEMIOLOGY OF DRUG USE IN PREGNANT WOMEN»


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Abstract

The paper deals with the safe use of antipyretics/analgesics in pregnant women. It analyzes physicians’ prescriptions of these drugs to pregnant women with fever and acute pain, which have been obtained during the multicenter study «Epidemiology of drug use in pregnant women». It has been found that the physicians prescribe 29 different drugs, some of them produce no analgesic effect; a range of medications prescribed by physicians is not recommended for use in pregnancy. Overall, the prescription of antipyretics/analgesics by therapists is more rational than that by obstetricians, gynecologists, and physicians of other specialties. However, all physicians are unfamiliar with the safety of drugs in relation to the trimester of pregnancy.

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About the authors

O. N TKACHEVA

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia

A. Yu BEVZ

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia

E. A USHKALOVA

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia

Email: eushk@yandex.ru

N. A CHUKHAREVA

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia

References

  1. Астахова А.В., Лепахин В.К. Лекарства. Неблагоприятные побочные реакции и контроль безопасности. — М.: ЭКСМО, 2008.
  2. Шефер К., Шпильтанн Х., Феттер К. Лекарственная терапия в период беременности и лактации. — М.: Логосфера, 2010.
  3. Alexander F.E., Patheal S.L., Biondi A. et al. Transplacental chemical exposure and risk of infant leukemia with MLL gene fusion // Cancer Res. — 2001. — Vol. 61. — Р. 2542—2546.
  4. Babb M., Koren G., Einarson A. Treating pain during pregnancy. //Can. Fam. Physician. — 2010. — Vol. 56, № 1. — Р. 25—27.
  5. Baerts W., Fetter W.P., Hop W.C. et al. Cerebral lesions in preterm infants after tocolytic indomethacin //Dev. Med. Child Neurol. — 1990. — Vol. 32. — Р 910—918.
  6. Black R.A., Ashley H. Over-the-œunter medications in pregnancy //Am. Fam. Physician. — 2003. — Vol. 67. — Р. 2517—2524.
  7. Chambers C.D., Tutuncu Z.N., Johnsonl D. et al. Human pregnancy safety for agents used to treat rheumatoid arthritis: adequacy of available information and strategies for developing post-marketing data //Arthr. Res. Ther. — 2006. — Vol. 8. — Р. 225.
  8. CLASP Collaborative Group. CLASP: a randomized trial of low-dose aspirin for the prevention and treatment of preeclampsia among 9364 pregnant women // Lancet. — 1994. — Vol. 343. — Р. 619—629.
  9. Ericson K., Kallen B.A.J. Non-steroidal anti-inflammatory drugs in early pregnancy//Reprod. Toxicol. — 2001. — Vol. 15, № 4. — Р. 371—375.
  10. Gill E.J., Contos M.J., Peng T.C. Acute fatty liver of pregnancy and acetaminophen toxicity leading to liver failure and postpartum liver transplantation. A case report //J. Reprod. Med. — 2002. — Vol. 47, № 7. — Р. 584—586.
  11. Kacew S. Effects of over-the-counter drugs on the unborn child: what is known and how should this influence prescribing? // Paediatr. Drugs. — 1999. — Vol. 1, № 2. — Р. 75—80.
  12. Kallen B.A.J., Olausson P.O. Maternal drug use in early pregnancy and infant cardiovascular defect //Reprod. Toxicol. — 2003. — Vol. 17. — Р 255—261.
  13. Koren G. et al. Nonsteroidal anti-inflammatory drugs during third trimester and the risk of premature closure of the ductus arteriosus: a meta-analysis //Ann.of Pharmacother. — 2006. — Vol. 40, № 5. — Р. 824—829.
  14. Kozer E., Costei A.M., Boskovic R. et al. Effects of aspirin consumption during pregnancy on pregnancy outcomes: meta-analysis //Birth Defects Res. B. Dev. Reprod. Toxicol. — 2003. — Vol. 68, № 1. — Р. 70—84.
  15. Li D.-K., Liu L., Odoul R. Exposure to non-steroidal antiinflammatory drugs during pregnancy and risk of miscarriage: population based cohort study //Br. Med. J. — 2003. — Vol. 327. — Р. 368—370.
  16. Major C.A., Lewis D.F., Harding J.A. et al. Tocolysis with indomethacin increasing the incidence of necrotizing enterocolitis in the low- birth-weight neonate //Am. J. Obstet. Gynecol. — 1994. — Vol. 170. — Р. 102—106.
  17. Nielsen G.L., Sorensen H.T., Larsen H. et al. Risk of adverse birth outcome and miscarriage in pregnant users of nonsteroidal anti-inflammatory drugs: population based observational study and case-control study //Br. Med. J. — 2001. — Vol. 322. — Р 266—270.
  18. Rebordosa C., Kogevinas M., Bech B.H. et al. Use of acetaminophen during pregnancy and risk of adverse pregnancy outcomes // Int. J. Epidemiol. — 2009. — Vol. 38, № 3. — Р 706—714.
  19. Sharpe C.R., Franco E.L. Use of dipyrone during pregnancy and risk of Wilms’ tumor. Brazilian Wilms’ Tumor Study Group //Epidemiology. — 1996. — Vol. 7. — Р 533—535.
  20. Splinter M.Y., Sagraves R., Nightengale B. et al. Prenatal use of medications by women giving birth at a university hospital // South. Med. J. — 1997. — Vol. 90. — Р. 498—502.
  21. Tassinari M.S., Cook J.C., Hurtt M.E. NSAIDs and developmental toxicity // Birth Defects Res B. Dev. Reprod. Toxicol. — 2003. — Vol. 68. — Р 3—4.
  22. Torfs C.P, Katz E.A., Bateson T.F. et al. Maternal medications and environmental exposures as risk factors for gastroschisis //Teratology. — 1996. — № 54. — Р. 84—92.
  23. Werler M.M., Mitchell A.A., Shapiro S. First trimester maternal medication use in relation to gastroschisis //Teratology. — 1992. — Vol. 45. — Р 361—367.
  24. Werler M.M., Sheehan J.E., Mitchell A.A. Maternal medication use and risks of gastroschisis and small intestinal atresia // Am. J. Epidemiol. — 2002. — Vol. 155, № 1. — Р. 26—31.

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