ROLE OF LEUKOCYTES AND CYTOKINES IN THE DEVELOPMENT AND REGULATION OF LABOR ACTIVITY AT TERM BIRTH


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Abstract

The review gives data available in the literature on the relationship of the occurrence of labor activity to a local inflammatory response developing in the uterine-placental unit. Its main components are leukocyte infiltration, as well as the increasing synthesis of proinflammatory cytokines in the cervix uteri, myometrium, placenta, and fetal membranes. In addition, different mechanisms of the interaction between the cytokines and the major known modulators of uterine contractility were revealed.

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About the authors

V. P RUMYANTSEVA

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia

Email: valya-ru@yandex.ru

O. R BAYEV

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia

V. N VERYASOV

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia

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