PROGNOSTIC FACTORS FOR THE EFFICACY OF MIFEPRISTONE IN PREPARATION FOR LABOR


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Abstract

Objective. To study the clinical and ultrasound criteria that are of prognostic importance in defining the efficiency of labor preinduction and induction with mifepristone. Subjects and methods. Eighty-two women in whom the cervix uteri was prepared for labor with mifepristone in a dose of 200 mg twice at a 24-hour interval were examined. The following prognostic factors, such as maternal age, parity, weight, and uterine cervical length measured by transvaginal ultrasonography (USG), were studied. Results. Age over 30 years was found to be a prognostic factor to reduce the efficiency of preparation of the cervix uteri for labor. There is also a relationship between parity and the outcome of mifepristone preinduction that is characterized by the higher rate of delivery in primiparas than in multiparas. A cervical length of 26 mm during transvaginal USG is a statistically significant factor to reduce the likelihood of delivery after preinduction. The mifepristone dosage to patient weight ratio is of great prognostic value for the maturation of the cervix uteri and for the course of an act of delivery. Mifepristone preinduction at 41 weeks’ or more gestation is accompanied by the higher rate of cesarean delivery than that at 40—41 weeks’ gestation.

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About the authors

O. R BAYEV

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia

Email: metod_obsgyn@hotmail.com

V. P RUMYANTSEVA

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia

G. M BURDULI

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia

O. L POLYANCHIKOVA

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia

S. V RUBTSOVA

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia

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