IMPACT OF MATERNAL MAGNESIUM SULFATE THERAPY FOR PREECLAMPSIA/ECLAMPSIA ON A NEWBORN INFANT (CLINICAL OUTCOMES): META-ANALYSIS


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Abstract

Objective. To evaluate the impact of magnesium sulfate therapy (MST) on a newborn infant (perinatal mortality; neonatal hypotension; 1-minute Apgar scores less than 7; 5-minute Apgar scores less than 7; a need for tracheal intubation in a delivery room; a need for neonatal transfer from a delivery room to an intensive care unit (ICU); ICU treatment for more than 7 days). Materials and methods. The results of 13 randomized clinical trials published in English-language medical journals and in the reports of the Cochrane Society over 1990—2010 were analyzed, which met the following requirements: a prospective study; randomization; the presence of a control group; information hiding from an investigator/an analyst; a study of at least one of the clinical outcomes given in the objective of the study; a statistical description of an effect in terms of a relative risk with a 95% confidence interval. Results. MST in a mother with preeclampsia/eclampsia does not increase the rate of neonatal outcomes, such as the rate of fatal outcomes, Apgar scores less than 7 at 1 and 5 minutes, a need for tracheal intubation in a delivery room; a need for neonatal transfer from a delivery room to an ICU; neonatal ICU stay for more than 7 days. Evaluation of the efficacy of magnesium sulfate versus phenytoin has shown the statistically significant advantage of the former. Conclusion. Magnesium sulfate is not an independent additional risk factor for developing the poor outcomes described in the objective of the study. However, it should be noted that this study deals with the neonatal infants, the most of whom are full-term and have no obvious intrauterine developmental abnormalities or serious perinatal pathology.

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About the authors

E. M SHIFMAN

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia

Email: e_shifman@oparina4.ru

E. N BAIBARINA

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia

D. S KRYUCHKO

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia

G. P TIKHOVA

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia

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