ROLE OF GENETIC FACTORS IN THE GENESIS OF POSTMENOPAUSAL OSTEOPOROSIS


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Abstract

This paper considers the major components of the gene network of osteoporosis. As of now, the conventional study of the risk factors for postmenopausal osteoporosis (PMO) deals with a search for the gene mutations associated with bone mineral density (BMD) and PMO. Papers on the association between VDR, LRP-5, RANK, RANKL, ОPG, ESR1, and ESR2 gene polymorphisms and decreased BMD and fractures are analyzed. The given analysis of the data available in the literature suggests that the complex analysis considering the pathomorphological, pathophysioloical, and phenotypic changes in bone tissue with the allelic features of the genes associated with BMD and PMO, the combined effect of a few polymorphisms, gene-gene interactions, and population peculiarities must be a promising area of a genetic study.

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About the authors

E. V BORDAKOVA

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia

Email: 0, (8-916) 460-66-00 E- maihyatri09@mail.ru

A. E DONNIKOV

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia

O. V YAKUSHEVSKAYA

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia

S. V YURENEVA

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia

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