ROLE OF VITAMIN D IN THE PREVENTION AND TREATMENT OF POSTMENOPAUSAL OSTEOPOROSIS


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

Vitamin D deficiency is one of the most common hypovitaminoses worldwide. The paper gives the data available in the literature on that in postmenopause there is almost a four-fold decrease in the capacity of the skin to produce vitamin D; in this connection elderly subjects are at increased risk for fall-related fractures. Vitamin D is a component of combination therapy for postmenopausal osteoporosis as its deficiency negatively affects the results of antiresorptive therapy: the patients with low vitamin D levels at baseline were observed to have a low increment during bisphosphonate therapy. At present there is no agreement on the required daily vitamin D dose for elderly subjects and there are no uniform standards for blood vitamin D concentration either.

Full Text

Restricted Access

About the authors

E. V BORDAKOVA

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia

Email: yatri09@mail.ru
Moscow

S. V YURENEVA

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia

Moscow

References

  1. Лесняк О.М.Социально-экономическое бремя остеопороза для Российской Федерации // Тезисы докл. IV Российского конгресса по остеопорозу. - СПб., 2010. - С. 27.
  2. Остеопороз: диагностика, профилактика и лечение. Клинические рекомендации / Под ред. О.М. Лесняк, Л.И. Беневоленской - М.: ГЭОТАР-Медиа, 2009.
  3. Торопцова Н.В., Беневоленская Л.И. Уровень витамина D в сыворотке крови У женщин в постменопаузе // Тезисы II Российского конгресса по остеопорозу. -Ярославль, 2005. - С. 97-98.
  4. Adami S., Giannini S., Bianchi G. Vitamin D status and response to treatment in post-menopausal osteoporosis // Osteoporos Int. - 2009. - Vol. 20, № 2. - P. 239-244.
  5. Avenell A., Gillespie W.J., Gillespie L.D. Vitamin D and vitamin D analogues for preventing fractures associated with involutional and post-menopausal osteoporosis// Cochrane Database Syst. Rev. - 2009. - Vol. 15, № 2. - CD000227.
  6. Bibuld D. Health disparities and vitamin D // din. Rev. Bone Miner. Metab. - 2009. -Vol. 7, № 1. - Р. 63-76.
  7. Bischoff-Ferrari H.A., Dawson-Hughes B., Willett W.C. et al. Effect of vitamin D on falls: A meta-analysis // J.A.M.A. - 2004. - Vol. 291, № 16. - Р. 1999-2006.
  8. Bischoff-Ferrari H.A., Willett W.C., Wong J.B. et al. Fracture prevention with vitamin D supplementation: a meta-analysis of randomized controlled trials // J.A.M.A. - 2005. -Vol. 293, № 18. - Р. 2257-2264.
  9. Bischoff-Ferrari H.A., Giovanucci E., Willett W.C. Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes // J. Am. Clin. Nutr. - 2006. -Vol. 84. - Р. 18-28.
  10. Bischoff-Ferrari H.A., Dawson-Hughes B., Staehelin H.B. et al. Fall prevention with supplemental and active forms of vitamin D: a meta-analysis of randomised controlled trials // Br. Med. J. - 2009. - Vol. 339. -Р. 3692.
  11. Cerdâ Gabaroi D., Peris P., Monegal A. et al. Sеarch for hidden secondary causes in postmenopausal women with osteoporosis // Menopause. - 2010. - Vol. 17, № 1. - Р. 135-139.
  12. Dawson-Hughes B., Mithal A., Bonjour J.P. et al. IOF position statement: vitamin D recommendations for older adults // Osteoporos Int. - 2010. - Vol. 21, № 7. - Р. 1151-1154.
  13. Deane A., Constancio L., Fogelman I., Hampson G. The impact of vitamin D status on changes in bone mineral density during treatment with bisphosphonates and after discontinuation following long-term use in post-menopausal osteoporosis // BMC Musculoskelet. Disord. - 2007. - № 8. - P. 3.
  14. Dietary reference intakes for calcium and vitamin D // Food and nutrition board. Institute of Medicine of the United States. - Washington, DC: National Academies Press, 2011. Available at: http://www.iom.edu/Reports/2010/ Dietary-Reference-Intakes-for-Calcium-and-Vitamin-D. aspx Accessed December 6, 2010.
  15. Geller J.L., Hu B., Reed S. Increase in bone mass after correction of vitamin D insufficiency in bisphosphonatetreated patients // Endocr. Pract. - 2008. - Vol. 14, № 6. -Р. 797-798.
  16. Gonzales C., Pharm D. Vitamin D supplemention: an update // US Pharmacist. - 2010. http://www.medscape.com/ viewarticle/731722.
  17. Grigorie D., Sucaliuc A., Ivan M. Vitamin D status affects one year BMD response to ibandronate treatment in patients with postmenopausal osteoporosis // Osteoporosis Int. - 2010. - Vol. 21 (suppl.). - Р. 25-388.
  18. Heaney R.P., Davies K.M., Chen T.C. Human serum 25-hydroxycholecalciferol response to extended oral dosing with cholecalciferol // Am. J. Clin. Nutr. - 2003. - Vol. 77, № 1. - Р. 204-210.
  19. Holick M.F. Vitamin D: importance in the prevention of cancers, type 1 diabetes, heart disease, and osteoporosis // Am. J. Clin. Nutr. - 2004. - № 79. - Р. 362-371.
  20. Holick M.F. High prevalence of vitamin D inadequacy and implications for health // Mayo Clin. Proc. - 2006. -Vol. 81, № 3. - Р. 357-373.
  21. Holick M.F. Vitamin D deficiency // N. Engl. J. Med. - 2007. - № 357. - Р. 266-281.
  22. Holick M.F., Biancuzzo R.M., Chen T.C. et al. Vitamin D2 is as effective as vitamin D3 in maintaining circulating concentrations of 25-hydroxyvitamin D // J. Clin. Endocrinol. Metab. - 2008. - Vol. 93, № 3. -Р. 677-681.
  23. Holick M.F., Chen T.C. Vitamin D deficiency: a worldwide problem with health consequences // Am. J. Clin. Nutr. - 2008. - Vol. 87, № 4. - Р. 1080-1086.
  24. Holick M.F. Vitamin D and health: Evolution, biologic functions and recommended dietary intakes for vitamin D // Clin. Rev. Bone Miner. Metab. - 2009. -№ 7. - Р. 2-19.
  25. Holick M.F. Vitamin D: the other steroid hormone for muscle function and strength // Мenopause. - 2009. - Vol. 16, № 6. - Р. 1077-1078.
  26. Holick M.F., Garabedian M. Vitamin D: photobiology, metabolism, mechanism of action, and clinical applications // Primer on the metabolic bone diseases and disorders of mineral metabolism / Ed. M.J. Favus. - 6th ed. Washington, DC: American Society for Bone and Mineral Research, 2006.
  27. Management of osteoporosis in postmenopausal women: 2010 position statement of The North American Menopause Society // Menopause. - 2010. - Vol. 17, № 1. - Р. 23-24.
  28. Meier C., Woitge H.W., Witte K. et al. Supplementation with oral vitamin 3D and calcium during winter prevents seasonal bone loss: a randomized controlled open-label prospective trial // J. Bone Miner. Res. - 2004. - Vol. 19, № 8. -Р. 1221-1230.
  29. Tangpricha V., Koutkia P., Rieke S.M. Fortification of orange juice with vitamin D: a novel approach to enhance vitamin D nutritional health // Am. J. Clin. Nutr. - 2003. - № 77. -Р. 1478-1483.
  30. Vecino-Vecino C., Gratton M., Kremer R. Seasonal variance in serum levels of vitamin D determines a compensatory response by parathyroid hormone: study in an ambulatory elderly population in Quebec // Gerontology. - 2006. -Vol. 52, № 1. - Р. 33-39.
  31. Vega C.P. «D» is for dilemma: two vitamin guidelines, two recommendations Canada, 2011.http://www.medscape. com/viewarticle/734963.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies