MONITORING PATIENTS UNDERGOING CONIZATION OF THE CERVIX UTERI FOR CERVICAL INTRAEPITHELIAL NEOPLASIA (THE CLINICAL, MORPHOLOGICAL, AND MOLECULAR BIOLOGICAL ASPECTS OF THE PROBLEM)


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Abstract

Objective. To study of the importance of a complex of clinicomorphological studies and molecular testing of human papillomavirus (HPV) in the cervical canal epithelium when monitoring patients undergoing conization for cervical intraepithelial neoplasia (CIN). Material and methods. A retrospective clinicomorphological and molecular biological study was made using the material obtained from 167 women who had undergone knife conization for CIN II-III, CIN-III. A comparison group comprised 30 women with an HPV history and the signs of uterine cervicitis. Results. Cytological and immunocytochemical monitoring was made in 197 women, by using the markers p16 and Ki-67 and molecular testing of DNA of HPV of 21 types. A recurrence was found in 6 (3.6%) patients. Conclusion. A complex of clinicomorphological studies and molecular testing of HPV in the cervical canal epithelium is recommended to monitor patients who have undergone knife conization for CIN. Conclusion. A complex of clinicomorphological studies and molecular testing of HPV in the cervical canal epithelium is recommended to monitor patients who have undergone knife conization for CIN.

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About the authors

E. A KOGAN

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia

Email: koganevg@gmail.com

N. M FAIZULLINA

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia

A. Kh ISRAILOVA

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia

A. V KOZACHENKO

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia

T. A DEMURA

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia

Ya. A TEMISHEVA

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia

A. N EKIMOV

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia

A. E DONNIKOV

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia

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