PREMATURE BIRTH IN ASSISTED REPRODUCTIVE TECHNOLOGY PREGNANCY: WAYS OF PREVENTION


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Abstract

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia, Moscow Objective. To study the rate and outcomes of premature birth in pregnancy occurring with the use of assisted reproductive technologies (ART) and to develop ways to prevent complications. Subjects and methods. A study group included 365 women with ART pregnancy: 258 and 107 patients with singleton and multiple pregnancy, respectively. A control group consisted of 394 patients with spontaneous pregnancy, including 302 with singleton pregnancy and 92 with multiple one, respectively. Results. In induced pregnancy, the frequency of obstetric complications and poor outcomes, premature births in particular, was 1.1—3.22 times greater than that in spontaneous pregnancy. The obtained results are primarily due to multiple births and, in case of singleton pregnancy, to the older age of the study group patients, as well as to somatic, obstetric and gynecologic histories. An analysis of the course of pregnancy and further outcomes depending on the ART procedure demonstrated that the least frequency of obstetric complications was noted after transfer of cryopreserved embryos. Conclusion. The prophylaxis of premature births in induced pregnancy should aim primarily at preventing multiple pregnancy.

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References

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