A RELATIONSHIP OF THE RESULTS OF SUPEROVULATION INDUCTION AND THE NUMBER OF EMBRYOS OBTAINED WITHIN AN IN VITRO FERTILIZATION PROGRAM TO THE TYPE OF CHROMOSOME ABERRATION IN THE KARYOTYPE OF A PATIENT

Objective. To estimate an ovarian response to superovulation induction and the period of early embryogenesis in the married couples with one being a carrier of balanced karyotype translocation in relation to its type. Subjects and methods. The investigation enrolled 27 married couples with one being a balanced translocation carrier. All the couples were included into an in vitro fertilization (IVF) program. Results. Analysis of the f indings indicated that there was no relationship between the type of mutation and that of (primary or secondary) infertility. A group of patients with Robertsonian translocations was shown to have a statistically significantly larger number of oocytes (р=0.00037) and embryos (р=0.00149) than that of patients who were reciprocal translocation carriers. The couples where the women were mutation carriers showed no statistically significant difference in the number of obtained oocytes and embryos as compared to the couples where the men were mutation carriers. At the same time the mean number of good-quality embryos on day 3 of development in the couples with female and male mutation was 2.57±2.44 and 3.85±1.87, respectively (p=0.0194, Mann-Whitney test). The group of reciprocal translocation carriers showed the same gender-based tendency: fewer oocytes and embryos were obtained in the couples with female mutation carriers. In that of Robertsonian translocation carriers, the obtained oocytes were fewer and the obtained embryos were more in the couples with male mutations carriers.

balanced translocations, oocytes, embryos, in vitro fertilization, superovulation induction